Status of Copper and Magnesium Levels in Diabetic Nephropathy Cases: a Case-Control Study from South India

Prabodh, Sakshi; Prakash, D. S. R. S.; Sudhakar, G.; Chowdary, N V S; Desai, Vishal; Shekhar, Ravi

doi:10.1007/s12011-010-8750-x

Cited by 23 publications

(16 citation statements)

References 12 publications

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“…Without the results of serum copper as a confounding factor, the interpretation of the results of our study is difficult, although Prabodh in a study from India did not find significant difference of serum copper between diabetic patient with and without nephropathy. [10] Also, some animal and human studies have evaluated serum or urine ceruloplasmin to better clarify the roles of copper in similar settings. [121517] However, multiple other studies have evaluated serum or urinary copper without concurrent evaluation of ceruloplasmin.…”

Section: Discussionmentioning

confidence: 99%

Correlation between microalbuminuria and urinary copper in type two diabetic patients

Talaei

Jabari

Bigdeli

et al. 2011

Indian J Endocr Metab

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Introduction:Diabetes mellitus and its chronic complications may be associated with alterations in the plasma, tissue, and urinary levels of some trace elements like copper.Materials and Methods:This cross-sectional study evaluates the 24 hour urinary copper levels in type 2 diabetic patients with microalbuminuria in comparison with patients without albuminuria.Results:Forty-two patients with microalbuminuria (case) and 40 patients without microalbuminuria (control) participated in the study. Mean (CI 95%) urinary copper levels were 36.14 (14.54–57.74) and 14.77μcg /L (10.17–19.37) in the case and control groups respectively (P = 0.003). There was no significant effect of diabetes duration or HbA1c on urinary copper.Conclusion:The present study shows diabetic patients with microalbuminuria have increased urinary copper excretion, however does not exclude the potential toxic effects of this high copper excretion on the progression of diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

Correlation between microalbuminuria and urinary copper in type two diabetic patients

Talaei

Jabari

Bigdeli

et al. 2011

Indian J Endocr Metab

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“…Hypomagnesemia has been implicated in the development of diabetic complications due to enhanced renal Mg excretion [6,13,14]. The study of Prabodh suggested that hypomagnesemia may be related to development of diabetic nephropathy [15]. Hypomagnesemia was found to be related to weak glycemic control and increased incidence of nephropathy and retinopathy [16].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of magnesium on renal function in STZ-induced diabetic rats

Parvizi

Parviz

Tavangar

et al. 2014

J Diabetes Metab Disord

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BackgroundDiabetic nephropathy is a serious complication of T1D (type one diabetes mellitus). Persistent hyperglycemia and subsequent hypomagnesemia is believed to develop kidney damage by activation of oxidative stress. We conducted this study to investigate the renoprotective effect of magnesium sulfate (MgSO4) on renal histopathology and oxidative stress in diabetic rats.MethodsThe study included 70 male rats. The animals were divided into seven groups: control (CRL), control receiving MgSO4 (CRL + Mg1 & CRL + Mg8), diabetic (DM1 & DM8) and diabetic receiving MgSO4 (DM + Mg1 & DM + Mg8). Rats were given 20 mg/kg (i.p) Streptozocin (STZ) for 5 consecutive days in (MLD) multiple low doses to induce T1D. At day 10 treatment groups were received MgSO4 (10 g/l) in drinking water, for 1 or 8 weeks. The blood glucose, BUN and creatinine levels were measured. Renal tissue levels of malondialdehyde (MDA) were measured by thiobarbituric acid (TBA) method to evaluate the oxidative stress. Renal histopathology was done using H & E staining method.ResultsTreatment with MgSO4 significantly decreased the blood glucose in DM + Mg1 and DM + Mg8 groups as compared with DM1 and DM8. Magnesium treatment also decreased serum BUN and tissue level of MDA significantly in both short and long term treatment. The body weight loss and kidney weight to body weight ratio was improved by MgSO4. Histological results showed there were no differences between DM and DM + Mg groups.ConclusionOur findings showed that diabetic nephropathy is associated with high blood glucose level and oxidative stress (significant increase in MDA level). The renal dysfunction and oxidative stress can be improved by magnesium sulfate administration. It is suggested that protection against development of diabetic nephropathy by MgSO4 treatment involves changes in the blood glucose and oxidative stress.

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“…Magnesium is an important cofactor in several key enzymes involved in carbohydrate metabolism and is considered to play a role in glucose homeostasis and insulin action (11,12). Zinc is essential for the formation of both the stored and active forms of insulin and may be involved in the development or progression of both type 1 and type 2 diabetes (13)(14)(15). Copper and iron play important roles in the pathological processes that are ongoing in diabetic patients by participating in free radical reactions (16).…”

Section: Popular Scientific Summarymentioning

confidence: 99%

Association of multiple mineral and vitamin B group intake with blood glucose using quantile regression analysis: NHANES 2007–2014

Yan

et al. 2019

Food & Nutrition Research

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Background: Hyperglycaemia and diabetes have become major public health problems worldwide. There is increasing evidence that minerals and the vitamin B group might play specific roles in hyperglycaemia and the pathogenesis and progression of diabetes or metabolic complications. Objectives: The main aim of this study is to investigate the effect of mineral and vitamin B group supplementation on the blood glucose levels of different populations. Design: This was a cross-sectional study. Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 were used in this study. A total of 8,322 participants (4,169 men and 4,153 women) were included in the study. Quantile regression (QR) was performed to identify the influence of mineral and vitamin B group intake on the level of fasting plasma glucose (FPG) in individuals in different quantiles of FPG. Results: After adjusting for age, income, education, race, smoking, and alcohol consumption, FPG had a negative association with folic acid in individuals with normal or high FPG, with calcium in individuals with normal FPG, and with magnesium in males. FPG was negatively associated with folic acid and calcium in individuals with normal FPG, and magnesium in most of the quantiles for females. Discussion: Hyperglycaemia and diabetes are currently becoming popular research topics. However, little is known about how the whole continuum of blood glucose is associated with commonly researched nutrient supplementation in terms of hyperglycaemia and diabetes. Conclusions: The intake of calcium, folic acid and magnesium was negatively associated with blood glucose levels in individuals in different quantiles of FPG. Appropriate prevention and treatment strategies should be developed for people with different blood glucose levels.

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Status of Copper and Magnesium Levels in Diabetic Nephropathy Cases: a Case-Control Study from South India

Cited by 23 publications

References 12 publications

Correlation between microalbuminuria and urinary copper in type two diabetic patients

Correlation between microalbuminuria and urinary copper in type two diabetic patients

Protective effect of magnesium on renal function in STZ-induced diabetic rats

Association of multiple mineral and vitamin B group intake with blood glucose using quantile regression analysis: NHANES 2007–2014

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