Status of inflammation and alcohol use in a 6-month follow-up study of patients with major depressive disorder

Archer, Mari; Niemelä, Onni; Luoto, Kaisa; Kultti, Johanna; Hämäläinen, Mari; Moilanen, Eeva; Koivukangas, Antti; Leìnonen, Esa; Kampman, Olli

doi:10.1016/j.alcohol.2019.02.001

Cited by 8 publications

(11 citation statements)

References 36 publications

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“…Baseline cortisol levels were not significantly different between hazardous and non-hazardous alcohol users (F ( NAfCo, 2018 ; Archer et al, 2019 ) = 0.464, p = 0.502), although levels did significantly decrease from pre to post sampling F ( NAfCo, 2018 ; Archer et al, 2019 ) = 6.057, p = 0.022; Fig. 1 A).…”

Section: Resultsmentioning

confidence: 90%

“…Specifically, baseline plasma CRP levels were significantly higher in TT carriers of CRP rs1205 ( Fig. 2 A; F ( NAfCo, 2018 ; Archer et al, 2019 ) = 17.678, p < 0.001, SNK p = 0.001 vs CT and CC), and in GG carriers of FKBP5 rs3800373 ( Fig. 2 B; F (2,24 ) = 5.913, p = 0.009, SNK 0.007 vs TT and 0.016 vs GT).…”

Section: Resultsmentioning

confidence: 92%

“…Consumption of alcohol is related to inflammation and immune response activation ( Archer et al, 2019 ; Bishehsari et al, 2017 ; Crews et al, 2006 ), and biomarkers of inflammation can be used in conjunction with alcohol-use status to assess psychological health ( Archer et al, 2019 ). Biomarkers of inflammation have also been related to risk for addiction and alcohol dependence ( Crews, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents

Scholl

King²,

Pearson³

et al. 2022

Brain, Behavior, & Immunity - Health

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents

Scholl

King²,

Pearson³

et al. 2022

Brain, Behavior, & Immunity - Health

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“…Previous studies have emphasized the need for novel biomarkers to help detect processes in recovery of depression. All patients in this study were suffering from clinically significant depression, and we have previously reported a decrease in the depressive symptoms in all study groups during the 6 months follow-up [ 30 ]. We have also previously observed elevated serum levels in biomarkers of inflammation in depressed patients, and that the levels of these biomarkers appear to decrease during treatment [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…The study was approved by the local ethics committee and all participants provided written informed consent. The study protocol is outlined and published at Ostrobothnia Depression Study in ClinicalTrials.gov , Identifier NCT02520271; first posted date 11/08/2015, and by Archer et al [ 30 ]. The study protocol is described in detail: https://www.clinicaltrials.gov/ct2/show/NCT02520271?term=ODS&draw=2&rank=1 .…”

Section: Methodsmentioning

confidence: 99%

The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients

et al. 2022

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Background The role of Interleukin-1 Receptor antagonist (IL-1Ra), an innate antagonist to pro-inflammatory cytokine IL-1, has attracted increasing attention due to its potential pathogenic and therapeutic implications in depression. However, the role of alcohol and adiposity in modulating IL-1Ra cytokine pathway in depressed patients has remainned unknown. The aim of this study was to follow the changes in IL-1Ra serum levels in depressed patients with or without simultaneous alcohol use disorder (AUD) and different degrees of adiposity during 6 months of follow-up. Materials and methods A total of 242 patients with depression were followed for 6 months. At baseline 99 patients had simultaneous AUD. Levels of serum IL-1Ra and common mediators of inflammation (IL-6, hs-CRP) were measured. Clinical assessments included Body Mass Index (BMI), Montgomery-Asberg Depression Rating Scale (MADRS) and Alcohol Use Disorders Identification Test (AUDIT) scores. Results Significant reductions in clinical symptoms and IL-1Ra were observed during 6-month follow-up. In hierarchical linear regression analysis, the effect of MADRS score, age, gender, and smoking had a combined effect of 2.4% in the model. The effect of AUDIT score increased the effect to 4.2% of variance (p = 0.08), whereas adding BMI increased the effect to 18.5% (p < 0.001). Conclusion Adiposity may influence the IL-1Ra anti-inflammatory response in depressed patients, whereas the effect of alcohol consumption in these patients seems insignificant. These findings should be considered in studies on the role of IL-1Ra in depression. Trial registration Ostrobothnia Depression Study in ClinicalTrials.gov , Identifier NCT02520271.

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Erkrankungen von Leber und Pankreas

Kapfhammer¹

2022

Depression, Angst, Traumatischer Stress Und Internistische Erkrankungen

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Status of inflammation and alcohol use in a 6-month follow-up study of patients with major depressive disorder

Cited by 8 publications

References 36 publications

Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents

Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents

The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients

Erkrankungen von Leber und Pankreas

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