Status of Lipid Peroxidation, Some Antioxidant Enzymes and Erythrocytic Fragility of Crossbred Cattle Naturally Infected with Theileria annulata

Grewal, A. S.; Ahuja, Chetna; Singha, S. P. S.; Chaudhary, K.

doi:10.1007/s11259-005-4682-x

Cited by 56 publications

(51 citation statements)

References 10 publications

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“…Thus, it can be suggested that the invasion of RBCs by the parasites could markedly affect key antioxidant defense barriers, resulting in significant RBC damage and finally leading to extravascular hemolysis. Our data corroborate the previous studies on bovine tropical theileriosis (Rezaei and Dalir-Naghadeh, 2006;Nazifi et al, 2009), but Grewal et al (2005) reported that the GPX activity was significantly elevated whereas the enzymes SOD and catalase showed no remarkable changes in cattle infected with T. annulata. They concluded that the increased level of GPX during the infection could be due to the fact that this enzyme activity is the major mechanism for the intracellular destruction of lipid peroxides rather than SOD or catalase activity, while our findings showed that, parallel to the role of GPX, the activities of SOD and catalase could also be important factors for RBCs to scavenge the oxidant agents during the parasitemia.…”

Section: Discussionsupporting

confidence: 93%

“…On the other hand, other studies have suggested that erythrocyte destruction during oxidative stress was related to lipid peroxidation of the RBCs (Friedman, 1979;Grewal et al, 2005). This process might be the cause of morphological changes in erythrocyte surface (Saluja et al, 1999;Grewal et al, 2005), which increase erythrocyte susceptibility to phagocytosis.…”

Section: Introductionmentioning

confidence: 97%

“…Also, despite previous studies on bovine tropical theileriosis pointing out an immune-mediated hemolysis indicated by the presence of a hemagglutinin in T. annulata infected calves (Hooshmand-Rad, 1976), some recent findings suggest that anemia could be a consequence of the oxidative damage of RBCs, as well as significant modulation of erythrocytic antioxidant enzymes activities (Shiono et al, 2003;Rezaei and Dalir-Naghadeh, 2006;Nazifi et al, 2008). On the other hand, other studies have suggested that erythrocyte destruction during oxidative stress was related to lipid peroxidation of the RBCs (Friedman, 1979;Grewal et al, 2005). This process might be the cause of morphological changes in erythrocyte surface (Saluja et al, 1999;Grewal et al, 2005), which increase erythrocyte susceptibility to phagocytosis.…”

Section: Introductionmentioning

confidence: 99%

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Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Razavi¹,

Nazifi²,

Mokhtari³

et al. 2015

Research J. of Parasitology

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Malignant ovine theileriosis is a fatal disease of sheep caused by Theileria hirci. The present study was designed to estimate the levels of plasma Homocysteine (Hcy), antioxidant enzymes, antioxidant vitamins and lipid peroxidation of erythrocytes and also to evaluate their correlations in different parasitemia rates in naturally infected sheep. Fifty Iranian sheep, about 1-2 years old, naturally infected with T. hirci were selected and divided into 2 subgroups according to their parasitemia rates (<2%, 2-4%). Ten non-infected animals were also selected as controls. Blood samples were collected and Hcy, antioxidant enzymes, antioxidant vitamins and lipid peroxidation of erythrocytes were measured. Our results showed that the activities of erythrocytic antioxidant enzymes including SOD, GPX and catalase were substantially reduced in infected sheep. Furthermore, the animals with higher parasitemia rate showed remarkable declines in SOD, GPX and catalase activities. There was a significant rise in the level of MDA, particularly in the animals with the higher (2-4%) parasitemia rates. In addition, it was evident that coinciding with the elevation of the parasite-bearing erythrocytes in infected animals, the level of lipid peroxidation in RBC membrane was significantly increased. Although the concentration of vitamin C showed a significant decrease in infected sheep with <2% parasitemia rate, the concentrations of antioxidant vitamins (A and E) generally showed no remarkable alterations. In our study, a significant increase was evident in the level of homocysteine in sheep suffering from theileriosis. Our data also showed that the increase in of parasitemia was coupled with the elevation of homocysteine level (r = 0.34, p<0.05).

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Razavi¹,

Nazifi²,

Mokhtari³

et al. 2015

Research J. of Parasitology

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“…Lipid peroxidation in the RBC hemolysate was determined as thiobarbituric acid reactive substance (TBARS) according to Grewal et al (2005). The method is depended on forming a color complex between the products of lipid peroxidation and thiobarbituric acid (TBA).…”

Section: Biochemical Analysismentioning

confidence: 99%

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

Esmaeilnejad

Tavassoli

Asri‐Rezaei

et al. 2012

Acta Parasitologica

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This study aimed to assess lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis. Red blood cell count (RBC), hemoglobin (Hb) concentration, packed cell volume (PCV), malondialdehyde (MDA) concentration, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activities and total antioxidant capacity (TAC) were determined in 15 goats naturally infected with B. ovis as well as same number of healthy goats. The parasitological diagnosis was confirmed using polymerase chain reaction (PCR) analysis by amplifying a partial 18S rRNA gene sequence of B. ovis. Percentage of parasitemia varied from 0.01 to 1%. The activities of erythrocyte GSH-Px, SOD, CAT and TAC were significantly lower (p<0.05) in the infected goats than in healthy ones. MDA concentration in erythrocytes of infected goats was significantly higher in infected goats than in healthy ones (p<0.05). Severity of parasitemia showed a positive correlation with the MDA and negative correlation with PCV, SOD, CAT, GSH-Px and TAC. Also, MDA was negatively correlated with PCV, SOD, CAT, GSH-Px and TAC. The results of this study suggested that oxidative damage to RBCs may contribute to the pathogenesis of anemia in caprine babesiosis.

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“…Research carried out in recent years demonstrates a relation between parasitic invasion and emergence of oxidative stress (Grewal et al 2005). A decrease in Cu and Zn content in the liver was reported by Dimri et al (2010) in sheep infested with Psoroptes ovis.…”

Section: Discussionmentioning

confidence: 84%

Concentration of selected transition metals in layer hens non-infested and infested with Dermanyssus gallinae

2012

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The aim of this study was to determine the concentration of selected transition metals, i.e. iron (Fe), copper (Cu) and zinc (Zn) in the livers of laying hens free from and infested with the red mite (Dermanyssus gallinae) and to explain the effects of the invasion of this parasite on the content of those elements. The study was carried out on 24 Hy-Line Brown hens bred in battery cages. The birds were divided into two groups, free from and infested with D. gallinae. Concentration of analysed metals was determined using atomic absorption spectrophotometry. Based on this experiment, it was proved that a long-term (52 weeks) exposure of hens to D. gallinae resulted in a significant (P < 0.05) decrease of Fe, Cu and Zn in the liver. The mean content of analysed metals in the group infested with the parasite amounted to 31.42 mg Fe/ kg, 2.71 mg Cu/kg and 22.64 mg/kg, whereas in the non-infested group it was 38.51 mg Fe/kg, 3.12 mg Cu/kg and 26.53 mg Zn/kg. No significant (P < 0.05) alterations in haematological indicators were found between the examined groups of birds. The results may suggest that 3 weeks of recovery in hens are sufficient to bring about a considerable increase in concentration of analysed transition metals in the liver. Copper, zinc, iron, birds, red miteThe red mite (Dermanyssus gallinae) is the most harmful ectoparasite of poultry. It attacks both domestic and wild birds at any age and may occur in poultry units using different rearing and breeding systems . Infection with this parasite leads to severe irritation of birds, blood loss as a result of mite preying, toxic and allergenic effects of the parasite's saliva, mechanical damage to body integuments and increased susceptibility of birds to pathogenic micro-organisms.Metals, including transition metals such as iron, copper and zinc play an important role in living organisms. They are components and co-factors of numerous enzymes and proteins necessary to ensure proper body functions. Iron is the best-known, and with regard to its ability to rapid acceptance and transmission of electrons, the most dangerous of the transition metals. It participates in many metabolic processes, DNA synthesis, respiratory chain and processes leading to cell damage as a result of oxidative stress (Emerit et al. 2001). Copper is a natural component of many constitutional proteins of enzymatic properties (e.g., ceruloplasmin, cytochrome oxidase, metallothionein, superoxide dismutase) and it participates in numerous processes catalysing oxidation/ reduction reactions (Gaetke and Chow 2009). It demonstrates a haematopoetic effect, modulates immune processes and is necessary for the proper activity of many vitamins and hormones. Zinc fulfils a multidirectional biological function in the body, acting through numerous metalloenzymes and hormones, of which it is a component or an activator. It is also considered an essential element for the immune response, since

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Status of Lipid Peroxidation, Some Antioxidant Enzymes and Erythrocytic Fragility of Crossbred Cattle Naturally Infected with Theileria annulata

Cited by 56 publications

References 10 publications

Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

Concentration of selected transition metals in layer hens non-infested and infested with Dermanyssus gallinae

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