Status of Serum Copper and Zinc in Pre-Eclampsia

Muna, FZ; Sirazi, Asmm; Majumder, M; Serajuddin, K; Debnath, BC; Hossain, Md. Amzad

doi:10.3329/bjmb.v8i2.33279

Cited by 3 publications

(3 citation statements)

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“…In the present work, both groups were comparable as regard to patient age and gestational age. These results are comparable to those reported by Muna et al [33] and others [35][36] .…”

Section: Farzin and Sajadisupporting

confidence: 93%

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Selected Trace Elements in Egyptian Females with Preeclampsia

Emam¹,

Attia

2020

International Journal of Medical Arts

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Background: Evidence exist indicating that, trace elements could play a role in preeclampsia [PE]. However, controversy exist regarding the role of the value of trace elements supplementation on the pregnancy outcome. Aim of the work:To estimate serum levels of some trace elements [selenium, calcium, magnesium, iron and zinc] in females developed preeclampsia and compare them to healthy pregnant females and correlate it with pregnancy outcome.Patients and Methods: 140 females were included in each group [preeclampsia and controls]. All had been assessed clinically, and by laboratory and ultrasound investigations. In addition, serum levels of selenium, calcium, magnesium, iron and zinc, had been determined and correlated with pregnancy outcome.Results: There was statistically significant increase of all trace elements in preeclamptic when compared to control groups. There was significant increase of females with deficient zinc, iron, calcium, magnesium and selenium in PE when compared to control group [83.6%, 19.3%, 30.7%, 27.9% and 40.0% vs 22.9%, 5.7%, 4.3%, 2.9% and 5.0% respectively]. The odds ratio where higher for zinc, followed by selenium, magnesium, calcium and finally iron deficiency. In addition, zinc, iron, calcium, magnesium and selenium were inversely and significantly correlated with systolic blood pressure. Preeclampsia was associated with worse maternal-fetal outcome when compared to controls. Conclusion:Lower levels of studied trace elements are associated with development of preeclampsia and we assume that, supplementation by such elements could reduce the risk of preeclampsia. However, this assumption needs to confirmed in future trials.

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“…In the present work, both groups were comparable as regard to patient age and gestational age. These results are comparable to those reported by Muna et al [33] and others [35][36] .…”

Section: Farzin and Sajadisupporting

confidence: 93%

“…Zinc deficiency in PE may result from hemodilution caused by fluid retention, endogenous steroid production and fetal uptake of zinc from her mother circulation. It may also be due to reduced levels of zinc binding protein [33] .…”

Section: Farzin and Sajadimentioning

confidence: 99%

Selected Trace Elements in Egyptian Females with Preeclampsia

Emam¹,

Attia

2020

International Journal of Medical Arts

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“…Significantly higher serum copper was observed in the preeclamptic women in this study. Contradictory to the above study low level of serum copper was mentioned by Gayathri B and Lewandowska M et al [21,22] and no significant change in serum copper and serum zinc were reported by FZ Muna et al in preeclampsia [23]. In preeclampsia, it is presumed that mobilization of copper from maternal tissue, especially from damaged liver occurs due to vasoconstriction which may be responsible for raised serum copper.…”

Section: Discussionmentioning

confidence: 85%

Serum Copper and Serum Zinc in Preeclampsia: Cause or Effect?

Sayyed¹,

Sontakke²

2020

IJBcRR

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Background: Preeclampsia is multisystem disorder. Despite its prevalence and severity, the pathophysiology of this multisystem disorder is poorly understood. In concern regarding the increasing number of preeclamptic cases and lack of data about the levels of trace elements in preeclampsia, a case-control study was conducted with aim to determine the trace elements like serum total copper and serum total zinc in preeclampsia. Aims: To estimate alterations in serum copper and serum zinc in preeclampsia and to compare them with normal pregnant women. Study Design: This is a case control study, carried out in the Department of Biochemistry, MIMER Medical College, Talegaon Dabhade, Pune. Methods: The present study consisted of 120 study participants. These were divided into two groups. Group I - normal pregnant women as control (n=60) and Group II - preeclamptic group (n=60). The serum levels of copper and zinc were determined by inductively coupled plasma atomic emission spectrometry (ICP- AES) technique at IIT Mumbai. Results: Analysis revealed that mean values of total serum copper and total serum zinc were 196.20 ± 25.9 and 77.15 ± 14.5 (µg/dl) respectively in control group. In preeclamptic group, the mean values of copper and zinc were 213.13± 38.6 and 76.23 ± 13.13 (µg/dl) respectively. Copper was significantly increased in preeclamptic group, while non-significant reduction in levels of zinc levels was observed when compared to control group. Conclusion: In the present study, significantly high serum copper was observed in preeclamptic patients. Presence of high copper levels may be related factor in the etiopathogenesis of preeclampsia. Estimation of trace elements like copper and zinc may help clinicians in early diagnosis and minimizing or delaying complications of preeclampsia, hence preventing harm to both mother & fetus.

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SERUM IRON, COPPER and ZINC LEVELS IN PREECLAMPSIA AND NORMOTENSIVE PRIMIGRAVIDA FEMALES

Rana

Shahzad

Iftikhar³

et al. 2022

PBMJ

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Hypertensive ailments of pregnancy are major health problems for women and their babies around the world. Among the hypertensive disorders, preeclampsia and eclampsia are the major risk factors for maternal and neonatal morbidity and mortality. Now preeclampsia is considered a state of oxidative stress, in which over utilization of antioxidants may proceed into worst form of this disease. So, this study was planned to assess the role of serum iron, copper and zinc as co factors for antioxidant system, and compare their levels within primigravida normotensive pregnant women and preeclampsia women. Methods: It was a cross-sectional comparative study conducted in Biochemistry department, University of health Sciences, Lahore. The study was carried out on 90 women which were divided into two equal groups of 45 each, preeclampsia and controls respectively. Serum levels of iron, copper and zinc were estimated by atomic absorption spectrometer. Data analyses were performed by utilizing SPSS version 20.0. Results: Serum levels of Fe and Cu were raised in preeclampsia patients, 151.85±61.22 (μg/dl), 130.83±48.29 (μg/dl) and serum Zn levels were decreased 77.94±23.55 (μg/dl) when compared with normotensive controls 104.39±55.36 (μg/dl), 116.64±26.56 (μg/dl), and 92.77±22.91 (μg/dl) respectively. A positive correlation between copper and systolic blood pressure (r= 0.440), BMI and weight (r = 0.543), while negative correlation of iron with zinc (r = -0.285) was observed in preeclamptic women. A negative correlation between copper and zinc (r = -0.440) was also observed in normal pregnant women but no such correlation was observed within Preeclampsia group. Conclusion: It is apparent from this study that increased levels of iron and copper and decreased levels of zinc during pregnancy is associated with the pathogenesis of preeclampsia.

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Status of Serum Copper and Zinc in Pre-Eclampsia

Cited by 3 publications

References 5 publications

Selected Trace Elements in Egyptian Females with Preeclampsia

Selected Trace Elements in Egyptian Females with Preeclampsia

Serum Copper and Serum Zinc in Preeclampsia: Cause or Effect?

SERUM IRON, COPPER and ZINC LEVELS IN PREECLAMPSIA AND NORMOTENSIVE PRIMIGRAVIDA FEMALES

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