Status of treatment for the overall population of patients with stage IVb endometrial cancer, and evaluation of the role of preoperative chemotherapy: A retrospective multi-institutional study of 426 patients in Japan

Eto, Takako; Saito, Toshiaki; Shimokawa, Mototsugu; Hatae, Masayuki; Takeshima, Nobuhiro; Kobayashi, Hiroaki; Kasamatsu, Takahiro; Yoshikawa, Hiroyuki; Kamura, Toshiharu; Konishi, Ikuo

doi:10.1016/j.ygyno.2013.08.036

Cited by 29 publications

(28 citation statements)

References 28 publications

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“…Surgery plays a crucial role in treating primary peritoneal cancer and recurrent EC, although the indication depends on prognostic factors such as the site of recurrence, previous treatment, and patient performance status. Only 66% of patients with stage IV EC undergo surgery …”

Section: Resultsmentioning

confidence: 99%

“…However, the impact of CS is more significant than that of palliative care or exclusive radiotherapy and/or chemotherapy . The 5‐year OS rate in patients undergoing surgery is 22%, and the 4‐year OS rate for clinical treatment is 7.7% . The best results are obtained with complete CS when compared with incomplete CS and nonsurgery (progression‐free survival, 40.3 vs 11.0 vs 2.2 months; and OS, 42.2 vs 19.0 vs 2.2 months) .…”

Section: Resultsmentioning

confidence: 99%

“…Only 66% of patients with stage IV EC undergo surgery. 61 Among cases of EC with peritoneal dissemination, when compared with standard treatment of ovarian cancer with peritoneal disease, surgery followed by chemotherapy does not have the same survival outcomes, even in the patient group with complete CS (2-year OS of 57% vs 82%). However, the impact of CS is more significant than that of palliative care or exclusive radiotherapy and/ or chemotherapy.…”

mentioning

confidence: 94%

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Brazilian Society of Surgical Oncology guidelines for surgical treatment of endometrial cancer in regions with limited resources

Ribeiro

Cintra

Barrozo

et al. 2019

Journal of Surgical Oncology

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Background Approximately 70% of cancer‐related deaths occur in low‐ and middle‐income countries. In addition to social and racial inequalities, treatment options in these countries are usually limited because of the lack of trained staff and equipment, limited patient access to health services, and a small number of clinical guidelines. Objectives The Brazilian Society of Surgical Oncology developed this guideline to address these barriers and guide physicians treating patients with endometrial cancer (EC) in regions with limited resources and few specialized centers. Methods The guideline was prepared from 10 January to 25 October 20192019 by a multidisciplinary team of 56 experts to discuss the main obstacles faced by EC patients in Brazil. Thirteen questions considered critical to the surgical treatment of these patients were defined. The questions were assigned to groups that reviewed the literature and drafted preliminary recommendations. Following a review by the coordinators and a second review by all participants, the groups made final adjustments for presentations in meetings, classified the level of evidence, and voted on the recommendations. Results For all questions including staging, fertility spearing treatment, genetic testing, sentinel lymph node use, surgical treatment, and other clinical relevant questions, major agreement was achieved by the participants, always using accessible alternatives. Conclusions It is possible to provide adequate treatment for most EC patients in resource‐limited areas, but the first option should be referral to specialized centers with more resources.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 94%

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Brazilian Society of Surgical Oncology guidelines for surgical treatment of endometrial cancer in regions with limited resources

Ribeiro

Cintra

Barrozo

et al. 2019

Journal of Surgical Oncology

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“…Current National Comprehensive Cancer Network guidelines recommend that patients with high‐grade endometrial cancer diagnosed with extrauterine disease should be considered for maximal tumor cytoreduction surgery or preoperative chemotherapy if indicated . Other recent studies have also suggested favorable outcomes using neoadjuvant chemotherapy in patients with advanced‐stage disease, thus highlighting the importance of identification of extranodal metastatic disease before surgery in order to optimize individualized care. In attempt to identify patients with metastatic disease at the time of presentation, many centers perform routine preoperative imaging, most commonly a CT scan—the most frequently utilized, available, and affordable imaging modality.…”

Section: Introductionmentioning

confidence: 99%

Impact and cost of preoperative computed tomography imaging on the management of patients diagnosed with high‐grade endometrial cancer

Dai

Nahas

Murphy

et al. 2019

Intl J Gynecology & Obste

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Objective To investigate the cost and impact of routine preoperative computed tomography (CT) in patients with high‐grade endometrial cancer, and its role in identifying extrauterine disease. Methods We retrospectively identified patients with high‐grade endometrial cancer who underwent routine CT scan prior to surgical procedure between September 1, 2005, and January 31, 2015. Cases in which CT findings led to alterations in the treatment plan were documented. Incidental findings unrelated to endometrial cancer diagnosis were captured. Cost of imaging and diagnostic procedures was based on Ontario's Physician Services–Schedule of Benefits. Results Of 179 patients included, 57 (31.9%) were diagnosed with stage 3–4 disease. CT showed evidence of metastatic disease in 30 (16.8%) patients; however, planned surgical procedure was altered in only nine (5.0%) cases. CT results showed incidental findings requiring follow‐up in 78 (43.6%) cases, three of which were second malignancies. We estimate an expenditure of CAD$14 185.85 on routine imaging for every case in which surgical management was changed. Conclusions Preoperative CT imaging is efficacious in identifying extrauterine disease in patients with high‐grade endometrial cancer, although it seldom alters surgical management. Many of these CT scans will identify incidental findings requiring further interventions, resulting in substantial costs.

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“…Endometrial cancer (eca) is the 4th most common cancer in women and the 7th leading cause of cancer death in women in developed countries 1 . Patients with locally advanced disease or distant metastasis account for 15%-30% of cases, but for more than half the cancer-related deaths 2 .…”

Section: Introductionmentioning

confidence: 99%

Para-Aortic and Pelvic Extended-Field Radiotherapy for Advanced-Stage Uterine Cancer: Dosimetric and Toxicity Comparison between the Four-Field Box and Intensity-Modulated Techniques

et al. 2015

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Status of treatment for the overall population of patients with stage IVb endometrial cancer, and evaluation of the role of preoperative chemotherapy: A retrospective multi-institutional study of 426 patients in Japan

Cited by 29 publications

References 28 publications

Brazilian Society of Surgical Oncology guidelines for surgical treatment of endometrial cancer in regions with limited resources

Brazilian Society of Surgical Oncology guidelines for surgical treatment of endometrial cancer in regions with limited resources

Impact and cost of preoperative computed tomography imaging on the management of patients diagnosed with high‐grade endometrial cancer

Para-Aortic and Pelvic Extended-Field Radiotherapy for Advanced-Stage Uterine Cancer: Dosimetric and Toxicity Comparison between the Four-Field Box and Intensity-Modulated Techniques

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