Status (on/off) of oipA gene: their associations with gastritis and gastric cancer and geographic origins

Sallas, Mayara Luciana; Santos, Mônica Pezenatto dos; Orcini, Wilson Aparecido; David, Érica Boarato; Peruquetti, Rita Luiza; Payão, Spencer Luíz Marques; Rasmussen, Lucas Trevizani

doi:10.1007/s00203-018-1580-5

Cited by 18 publications

(21 citation statements)

References 26 publications

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“…A study report highlighted the oipA gene’s association with chronic gastritis development. Strains expressing functional OipA were most frequently isolated from patients with gastric cancer in Western countries [107].…”

Section: Virulence Factors Associated With Colonization Of Epithelmentioning

confidence: 99%

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Ansari

Yamaoka

2019

Toxins

189

141

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Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world’s population, and it is the strongest risk factor for developing gastric complications like chronic gastritis, ulcer diseases, and gastric cancer. To successfully colonize and establish a persistent infection, the bacteria must overcome harsh gastric conditions. H. pylori has a well-developed mechanism by which it can survive in a very acidic niche. Despite bacterial factors, gastric environmental factors and host genetic constituents together play a co-operative role for gastric pathogenicity. The virulence factors include bacterial colonization factors BabA, SabA, OipA, and HopQ, and the virulence factors necessary for gastric pathogenicity include the effector proteins like CagA, VacA, HtrA, and the outer membrane vesicles. Bacterial factors are considered more important. Here, we summarize the recent information to better understand several bacterial virulence factors and their role in the pathogenic mechanism.

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Section: Virulence Factors Associated With Colonization Of Epithelmentioning

confidence: 99%

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Ansari

Yamaoka

2019

Toxins

189

141

View full text Add to dashboard Cite

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“…Alignments with sequence lengths similar to the gene size and identity percentage higher than 95% were accepted. The on/off status of the oipA gene was determined by analyzing the sequences as described by Sallas et al [34] and by Dossumbekova et al [35].…”

Section: Identification Of Virulence Markers In H Pylori Strainsmentioning

confidence: 99%

Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced by Helicobacter pylori Infection in Human Gastric Epithelial Cells

et al. 2021

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Helicobacter pylori (H. pylori) is a pathogenic bacteria identified as a potential risk factor for gastritis, gastric ulcers and gastric cancer. During the stomach colonization, H. pylori triggers a strong inflammatory response and subsequent oxidative stress, which are associated with tissue damage. For this reason, it is of particular interest to develop alternative natural tools that enable modulation of the associated damaging immune response. With this purpose, we obtained grape seed extract (GSE) from sweet (not fermented) food grade seeds. The aim of our study was to investigate the effect of GSE and its two enriched procyanidins fractions (OPC and PPC) on the inflammatory process and oxidative stress produced by different H. pylori strains in human gastric epithelial cells (AGS). Anti-inflammatory activity was evaluated by measuring the level of interleukin-8 (IL-8) secretion. IL-8 production was significantly reduced in H. pylori-infected human gastric epithelial cells pre-treated with GSE or its enriched fractions when compared with non-pre-treated infected cells (from 21.6% to 87.8%). Pre-treatment with GSE or its fractions significantly decreased intracellular reactive oxygen species (ROS) production in AGS cells after infection, depending on the H. pylori strain. Our results also showed that GSE and its fractions demonstrate antibacterial activity against all strains of H. pylori used in the study. This work demonstrates the effectiveness of GSE enriched in procyanidins against the main events associated with H. pylori infection.

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“…In addition to oipA, the vacuolating cytotoxin A (vacA) has been observed as a virulence factor in H. pylori. VacA has been associated with apoptosis in epithelial cells of the gastric mucosa, immune system responsiveness, as well as the modulation of the permeability of polarized epithelial cells monolayers [10][11][12][13]. Historically, H. pylori has been implicated in gastritis, which reflects the inflammation of the gastric intestinal mucosa.…”

Section: H Pylori Infection and Gastric Cancermentioning

confidence: 99%

Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis

et al. 2021

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Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with H. pylori in gastric cancer development. Eighteen studies are included in the QES. There is increased prevalence of H. pylori exposure among the cases. The heterogeneity between the CES and individual effect sizes is also significant. Despite controlling for the confoundings, there is increased exposure to H. pylori among the gastric cancer cases, regardless of the differences in the geographic location. H. pylori in this synthesized literature illustrates the contributory role of this microbe in gastric carcinoma. Additionally, regardless of geographic locale, namely, South Korea or Spain, H. pylori is implicated in gastric cancer development.

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Status (on/off) of oipA gene: their associations with gastritis and gastric cancer and geographic origins

Cited by 18 publications

References 26 publications

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced by Helicobacter pylori Infection in Human Gastric Epithelial Cells

Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis

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