Staurosporine-induced differentiation in a human neuroblastoma cell line, NB-1.

MORIOKA, Hajimu; Ishihara, Masaru; SHIBAI, Hiroshiro; Suzuki, Toshimitsu

doi:10.1271/bbb1961.49.1959

Cited by 31 publications

(10 citation statements)

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“…Staurosporine, an indolo[2,3-α]carbazole alkaloid antibiotic, was first isolated in 1977 from S. staurosporeus [33] and, subsequently, from other Streptomyces strains, e.g., S. actuosus [29], S. roseoflavus [35], Streptomyces sp. strain M-193 [32] and Streptomyces sp.…”

Section: Structural Elucidation Of the Antifungal Compoundmentioning

confidence: 99%

Streptomyces scabiei subsp. xuchangensis, A NOVEL STREPTOMYCETE ISOLATE FOR STAUROSPORINE PRODUCTION AND A WHEAT TAKE-ALL CONTROL AGENT

Cai-yi¹,

ZHENG²,

Shen³

et al. 2012

Int J of Micr Res

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Abstract-The streptomycete strain SCY114 was isolated from a soil sample of Xuchang in Henan province, China. It possessed smooth grey spores borne in rectiflexible and spiral chains and was capable of using all of the International Streptomyces Project sugars. The melting temperature and G+C content were 81.8℃ and 61.6 mol%, respectively. The level of 16S rRNA gene sequence similarity between strain SCY114 and S. scabies ATCC49173 was 99.8%. However, the values of DNA-DNA relatedness between strain SCY114 and S. scabies ATCC49173 was 65.2%, and the strain SCY114 did not exhibit pathogenicity towards potato plants. Based on the phenotypic and genotypic evidence, strain SCY114 was identified as a subspecies of the Streptomyces scabiei, for which the name Streptomyces scabiei subsp. xuchangensis is proposed. Strain SCY114 strongly inhibited the in vitro mycelial growth of Gaeumannomyces graminis var. tritici as well as various other plant pathogenic fungi. The filtered culture broth of strain SCY114 was substantially more effective at controlling wheat take-all compared to the silthiofam, and the disease was reduced by 78.2%. An antifungal antibiotic was isolated from the fermentation broth of strain SCY114 using a series of chromatographic procedures. The molecular formula of the antibiotic was determined to be C28H26N4O3, and on the basis of the NMR data, the antibiotic was confirmed to be staurosporine.

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Section: Structural Elucidation Of the Antifungal Compoundmentioning

confidence: 99%

Streptomyces scabiei subsp. xuchangensis, A NOVEL STREPTOMYCETE ISOLATE FOR STAUROSPORINE PRODUCTION AND A WHEAT TAKE-ALL CONTROL AGENT

Cai-yi¹,

ZHENG²,

Shen³

et al. 2012

Int J of Micr Res

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“…Staurosporine (198a) possesses inhibitory activity against fungi and yeast but has no significant activity against bacteria [305] . It shows strong antihypertensive activity and pronounced in vitro activity against a number of experimental tumours [306] . It is a potent inhibitor of protein kinase C and platelet aggregation [307] .…”

Section: Staurosporinementioning

confidence: 99%

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

Ueda¹,

Hashimoto²,

Yamamura³

et al. 2011

J Antibiot

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“…Staurosporine (1a) possesses inhibitory activity against fungi and yeasts (but no significant activity on bacteria) [22], strong antihypertensive activity and shows pronounced inhibition of a number of experimental tumours [23]. Additionally, staurosporine (1a) and analogues are important biochemical tools [24] due to their potent inhibition of protein kinase C and platelet aggregation [25].…”

Section: Biological Activitiesmentioning

confidence: 99%

N-Carboxamido-staurosporine and Selina-4(14),7(11)-diene-8,9-diol, New Metabolites from a Marine Streptomyces sp.

Fotso

et al. 2006

J Antibiot

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In our screening of micro-organisms for novel bioactive natural products, a new staurosporinone, Ncarboxamido-staurosporine (1c), and a new sesquiterpene, (5S,8S,9R,10S)-selina-4(14),7(11)-diene-8,9-diol (2a), were isolated from the culture broth of the marine-derived Streptomyces sp. QD518. Their structures were determined by spectroscopic methods and by comparison of the NMR data with those of structurally related known natural products, which were isolated from the same strain.

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Staurosporine-induced differentiation in a human neuroblastoma cell line, NB-1.

Cited by 31 publications

References 0 publications

Streptomyces scabiei subsp. xuchangensis, A NOVEL STREPTOMYCETE ISOLATE FOR STAUROSPORINE PRODUCTION AND A WHEAT TAKE-ALL CONTROL AGENT

Streptomyces scabiei subsp. xuchangensis, A NOVEL STREPTOMYCETE ISOLATE FOR STAUROSPORINE PRODUCTION AND A WHEAT TAKE-ALL CONTROL AGENT

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

N-Carboxamido-staurosporine and Selina-4(14),7(11)-diene-8,9-diol, New Metabolites from a Marine Streptomyces sp.

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