Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A

Xu, Tianle; Shen, Xiang; Seyfert, Hans‐Martin

doi:10.1186/s12867-016-0069-5

Cited by 14 publications

(13 citation statements)

References 66 publications

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“…C/EBP α has been suggested to play a direct repressor role in Scd‐1 promoter activity (Xu et al. ). Insulin receptor expression was downregulated 1.4‐times, suggesting lower insulin sensitivity in the liver in chow‐fed FVB/N mice (Table ).…”

Section: Resultsmentioning

confidence: 99%

Is the FVB/N mouse strain truly resistant to diet-induced obesity?

et al. 2017

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C57Bl/6J mice are the gold standard animal model of diet‐induced obesity. These animals become obese with higher adiposity, blood fasting glucose, triglycerides, and total cholesterol when fed a high‐fat diet (HFD). Conversely, the FVB/N mouse line is thought to be resistant to diet‐induced obesity, with low or no weight gain and adiposity in response to a HFD. In this study, we investigated whether FVB/N mice are resistant or susceptible to metabolic disorder that is promoted by a HFD. Biometric parameters and blood chemistry were analyzed in C57Bl/6J and FVB/N mice that were fed a chow diet or HFD. Glucose and insulin sensitivity were assessed by performing the glucose tolerance test and measuring serum insulin/glucose and homeostasis model assessment‐insulin resistance. Metabolism‐related gene expression was investigated by real‐time reverse transcription polymerase chain reaction. Adipocyte morphology and liver steatosis were evaluated using standard histology. FVB/N mice had higher adiposity than C57Bl/6J mice that were fed a chow diet and were glucose intolerant. FVB/N mice that were fed a HFD presented higher insulin resistance and greater liver steatosis. Epididymal white adipose tissue exhibited severe inflammation in FVB/N mice that were fed a HFD. The FVB/N mouse strain is suitable for studies of diet‐induced obesity, and the apparent lack of a HFD‐induced response may reveal several strain‐specific events that are triggered by a HFD. Further studies of the FVB/N background may shed light on the complex multifactorial symptoms of obesity and metabolic syndrome.

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Section: Resultsmentioning

confidence: 99%

Is the FVB/N mouse strain truly resistant to diet-induced obesity?

et al. 2017

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“…Desat1 is expressed in both the fat body and the oenocytes, and reduced Desat1 expression results in increased abundance of saturated CHCs at the expense of unsaturated ones [ 32 , 33 ]. Of note, Desat1 expression varies between tissues, particularly in response to nutrient demand, in both flies and mammals [ 20 , 34 ], while its vertebrate homolog, SCD1 , is a key regulatory enzyme required in lipogenic tissues for fat storage [ 18 , 25 ]. We speculate that downregulation of Desat1 is needed for lipid mobilization and release to growing oocytes, similar to what has been observed for starvation response [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Tissue-specific insulin signaling mediates female sexual attractiveness

et al. 2017

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Individuals choose their mates so as to maximize reproductive success, and one important component of this choice is assessment of traits reflecting mate quality. Little is known about why specific traits are used for mate quality assessment nor about how they reflect it. We have previously shown that global manipulation of insulin signaling, a nutrient-sensing pathway governing investment in survival versus reproduction, affects female sexual attractiveness in the fruit fly, Drosophila melanogaster. Here we demonstrate that these effects on attractiveness derive from insulin signaling in the fat body and ovarian follicle cells, whose signals are integrated by pheromone-producing cells called oenocytes. Functional ovaries were required for global insulin signaling effects on attractiveness, and manipulations of insulin signaling specifically in late follicle cells recapitulated effects of global manipulations. Interestingly, modulation of insulin signaling in the fat body produced opposite effects on attractiveness, suggesting a competitive relationship with the ovary. Furthermore, all investigated tissue-specific insulin signaling manipulations that changed attractiveness also changed fecundity in the corresponding direction, pointing to insulin pathway activity as a reliable link between fecundity and attractiveness cues. The cues themselves, cuticular hydrocarbons, responded distinctly to fat body and follicle cell manipulations, indicating independent readouts of the pathway activity from these two tissues. Thus, here we describe a system in which female attractiveness results from an apparent connection between attractiveness cues and an organismal state of high fecundity, both of which are created by lowered insulin signaling in the fat body and increased insulin signaling in late follicle cells.

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“…[8,23,24]. Curiously, C/EBP also downregulates SCD1 expression in liver and udder during E. coli mastitis and is associated with a SREBP-1 downregulated expression [25]. to cell death or decreased SCD1 expression or activity.…”

Section: Stearoyl-coa Desaturase (Scd)mentioning

confidence: 99%

Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases

Peláez

Pariente

Pérez-Sala

et al. 2020

Cells

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In many tissues, stearoyl-CoA desaturase 1 (SCD1) catalyzes the biosynthesis of monounsaturated fatty acids (MUFAS), (i.e., palmitoleate and oleate) from their saturated fatty acid (SFA) precursors (i.e., palmitate and stearate), influencing cellular membrane physiology and signaling, leading to broad effects on human physiology. In addition to its predominant role in lipid metabolism and body weight control, SCD1 has emerged recently as a potential new target for the treatment for various diseases, such as nonalcoholic steatohepatitis, Alzheimer’s disease, cancer, and skin disorders. Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant Sterculia foetida with numerous biological activities. On the one hand, its ability to inhibit stearoyl-CoA desaturase (SCD) allows its use as a coadjuvant of several pathologies where this enzyme has been associated. On the other hand, additional effects independently of its SCD inhibitory properties, involve anti-inflammatory and protective roles in retinal diseases such as age-related macular degeneration (AMD). This review aims to summarize the mechanisms by which SA exerts its actions and to highlight the emerging areas where this natural compound may be of help for the development of new therapies for human diseases.

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Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A

Cited by 14 publications

References 66 publications

Is the FVB/N mouse strain truly resistant to diet-induced obesity?

Is the FVB/N mouse strain truly resistant to diet-induced obesity?

Tissue-specific insulin signaling mediates female sexual attractiveness

Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases

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