Stearoyl-CoA desaturase 1 regulates malignant progression of cervical cancer cells

Abstract

The primary regulatory gene for fatty acid synthesis, stearoyl-CoA desaturase 1 (SCD1), has been linked to the progression of several malignancies. Its role in cervical cancer remains unclear till now. This paper aimed to explore the role and mechanism of SCD1 in cervical cancer. The GEPIA database was used to perform a bioinformatics analysis of the role of SCD1 in cervical cancer staging and prognosis. The influences of SCD1 knockdown on cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) progress were then investigated. Following transcription factor Kruppel like factor 9 (KLF9) was discovered to be negatively correlated with SCD1, the regulatory role of KLF9 in the effects of SCD1 on cervical cancer cells and the signaling pathway was evaluated. According to the GEPIA database, SCD1 level was associated with the cervical cancer stage, the overall survival level, and the disease-free survival level. Cell proliferation, migration, invasion, and EMT progress were all hindered when its expression was knocked down. Novelty, KLF9 reversed the effects of SCD1 on cells, as well as the Akt/glycogen synthase kinase 3β (GSK3β) signaling pathway. Together, SCD1 was negatively regulated by KLF9 and it activated the Akt/GSK3β signaling pathway to promote the malignant progression of cervical cancer cells. Developing SCD1 inhibitors offers novel ideas for the biological treatment of cervical cancer.

USP14 promotes the proliferation of cervical cancer via upregulating β‐catenin

“…Studies have confirmed that many tumors, such as gastric and colorectal cancer, have a high expression of GSK3β 47 . In addition, a large number of studies have shown that in CC, GSK3β is involved in the regulation of the PI3K/Akt signaling pathway and the promotion of the malignant progression of CC cells 48,49 . This suggests that the regulatory role of USP14 in CC progression may be due to interactions with different key signaling pathways.…”

“…47 In addition, a large number of studies have shown that in CC, GSK3β is involved in the regulation of the PI3K/Akt signaling pathway and the promotion of the malignant progression of CC cells. 48,49 This suggests that the regulatory role of USP14 in CC progression may be due to interactions with different key signaling pathways. The pathway of USP14 action in CC may be a type of network rather than a single upstream and downstream pathway.…”

Unveiling the MUFA–Cancer Connection: Insights from Endogenous and Exogenous Perspectives

“…The expression of SCD1 was also found to be correlated with tumor grade and was associated with low overall survival in patients [ 167 ]. The association between high SCD1 expression in cancer tissue samples and poor clinical prognosis was also observed in bladder cancer [ 168 ], prostate cancer [ 169 ], pancreatic cancer [ 170 ], ovarian cancer [ 171 ], lung cancer [ 172 ], colorectal cancer [ 173 ], clear cell renal cell carcinoma [ 174 , 175 ], and cervical cancer [ 176 ]. A Swedish men study also showed an association between single-nucleotide polymorphisms in the SCD-1 gene and cancer death [ 59 ].…”

Fatty acid metabolism: A new therapeutic target for cervical cancer

“…The final results showed that the expression of KLF9/SCD1 could regulate the Akt/GSK3-β signaling pathway in CC cells and affect the proliferation, invasion and EMT process of CC cells. This phenomenon can be suppressed by knocking out SCD1 ( 38 ). Studies have also shown that SCD1 can regulate the level of miR-1908, and its high expression levels can promote the proliferation and invasion of CC cells ( 59 , 102 ).…”