Steigert Körperliche Anstrengung die Disposition zu Epidemischer Kinderlähme

Rudder, B. de; Petersen, G. A.

doi:10.1007/bf01780198

Cited by 17 publications

(3 citation statements)

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“…A history of great physical exertion preceding the onset ot severe paralysis has often evoked comment in cases of poliomyelitis (de Rudder and Peterson, 1938;Tucker, 1941), but no attempt (so far as I am aware) has been made to investigate this aspect of the problem statistically.…”

Section: Poliomyelitismentioning

confidence: 99%

Poliomyelitis

Wr¹

1947

BMJ

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Section: Poliomyelitismentioning

confidence: 99%

Poliomyelitis

Wr¹

1947

BMJ

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“…The possibility that invasion of the central nervous system by the virus of poliomyelitis may be aided by dehydration is also suggested. De Rudder and Petersen (15) noted that poliomyelitis occurred among athletes in a boys' school after strenuous exercise and thought that the virus was already present and gained access to the nervous system because the nerve cells had been rendered more susceptible. Perhaps the dehydration associated with the exercise may have increased the spread of the virus in the nervous tissue and thus led to infection.…”

Section: Effect Of Undernourishment With and Without Increase In Intementioning

confidence: 99%

The Effect of Undernourishment on the Susceptibility of the Rabbit to Infection With Vaccinia

Sprunt

1942

Journal of Experimental Medicine

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Experiments are reported in which it is shown that if rabbits are deprived of food, the lesions resulting from injection of vaccinia are either fewer or smaller; presumably this is partially explainable on reduction of available nutrients in the cell. The number and character of the lesions are also modified by the state of hydration of the interstitial tissues: If the amount of interstitial fluid is increased by permitting the animal to drink water, the lesions are even less numerous; but if the interstitial tissues are dehydrated either by withholding water or by injecting physiological saline solution into the peritoneal cavity, then the lesions are more numerous. The increase in interstitial fluids in these experiments was not due to decreased plasma proteins, for these were normal. In this respect, therefore, the rabbit differs from man, for unless the plasma proteins are reduced, simple starvation in man results in dehydration rather than edema of the tissues. From these experiments it is concluded that the virus is less able to multiply in the poorly nourished cell than in the well nourished one, and that hydration of the tissues increases the resistance of the tissue to infection while dehydration has the opposite effect. It is suggested that this is because hydration tends to localize the virus in situ, with result that fewer cells are exposed to it, while dehydration has the opposite effect. However, actual changes in cell susceptibility consequent upon altered water balance may be responsible for the effect.

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“…Underwood (1789) noted that infantile paralysis picked out the healthiest and best-fed children while Heine (1860) came to a similar conclusion. More recently De Rudder and Petersen (1938) suggested that the reason why athletic school boys are specially liable to develop severe paralysis is that dehydration of the tissues assists in the dissemination of the virus. Undoubtedly exercise during the incubation or preparalytic period increases the severity of the paralysis (Tucker, 1941 ;Russell, 1947).…”

Section: Virus Infections and Nutritional Factorsmentioning

confidence: 99%

Iv.—non‐specific Resistance Against Virus Infections

Findlay¹

1948

Journal of the Royal Microscopical Society

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Steigert Körperliche Anstrengung die Disposition zu Epidemischer Kinderlähme

Cited by 17 publications

References 0 publications

Poliomyelitis

Poliomyelitis

The Effect of Undernourishment on the Susceptibility of the Rabbit to Infection With Vaccinia

Iv.—non‐specific Resistance Against Virus Infections

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