Stellenwert der Radiologie in der Diagnostik der Knochensarkome

Vieth, Volker

doi:10.1007/s00132-019-03786-7

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…The diagnostic difficulty can also be seen in the example of radiological examinations, where in our study, only 44 to 63% of the X-rays gave a result suggesting a bone neoplasm. Although this examination is the gold standard in the diagnosis of bone tumors, especially in the initial stage of the disease, it is not a sensitive test, and it may give a false negative result [ 33 , 34 ]. This is also indirectly confirmed by our study, where X-rays detected bone neoplasms more often in the group where the tumor diameter was larger.…”

Section: Discussionmentioning

confidence: 99%

Delay in Diagnosis and Treatment of Primary Bone Tumors during COVID-19 Pandemic in Poland

Kotrych

Ciechanowicz

Pawlik

et al. 2022

Cancers

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Background: The COVID-19 pandemic has affected all of the medical specialties, including orthopedic oncology. Therefore, the aim of the study was to assess how it influenced the diagnostic and therapeutic processes for patients with bone neoplasms. Methods: We evaluated 87 patients treated due for bone neoplasms before (Group I, n = 36) and during the COVID-19 pandemic (Group II, n = 51). A delay in diagnosis was defined as the period between the initial clinical symptoms and the date of referral to an oncology center. The patients from Group II were asked to complete a short questionnaire regarding the COVID-19 pandemic. Results: The median general delay in diagnosis before the pandemic was 7 months, while during the pandemic, it was 10 months (p = 0.728). The biopsy delay was lower in the pre-pandemic group: median-6.5 vs. 12 days (p = 0.025). The patients from Group II were diagnosed with larger tumors compared to those in Group I: the median values were 75 vs. 56 mm (p = 0.025), respectively. After an X-ray examination, the bone neoplasms were suspected more frequently in the Group II: 63% vs. 44% cases (p = 0.024), respectively. In Group II, 20 (60.8%) cases of SARS-CoV-2 infection were reported, however, no respiratory failure cases were noticed. Conclusion: The pandemic affected the diagnostic process of primary bone tumors, resulting in delays in performing biopsies. During the pandemic, the patients reported larger diameters of their bone lesions.

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Section: Discussionmentioning

confidence: 99%

Delay in Diagnosis and Treatment of Primary Bone Tumors during COVID-19 Pandemic in Poland

Kotrych

Ciechanowicz

Pawlik

et al. 2022

Cancers

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Konventionelles epiphysäres Chondrosarkom des Kindes- und Jugendalters: ein Fallbericht

Mueller

Hardes²,

Streitbürger³

et al. 2021

Unfallchirurg

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QR-Code scannen & Beitrag online lesen ZusammenfassungEinleitung: Konventionelle Chondrosarkome treten als zweithäufigster, primär maligner Knochentumor vornehmlich im höheren Erwachsenenalter auf. Im Kindesund Jugendalter sind sie eine Rarität. Kasuistik: In diesem Fallbericht wird der Diagnose-und Behandlungsverlauf eines 13-jährigen Jungen mit symptomatischem, chondrogenem Tumor des rechten distalen Femurs vorgestellt, der histopathologisch einem epiphysären, mittelgradig differenzierten Chondrosarkom (G2) zugeordnet werden konnte. Diskussion: Mögliche radiologische und histopathologische Differenzialdiagnosen, wie das Chondroblastom oder das chondroblastische Osteosarkom, werden erörtert und die diagnostischen Behandlungsschritte sowie die Therapie des konventionellen Chondrosarkoms vor dem Hintergrund tumororthopädisch etablierter Behandlungsstandards diskutiert.

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Using Machine Learning to Unravel the Value of Radiographic Features for the Classification of Bone Tumors

Pan

Liu

Zheng

et al. 2021

BioMed Research International

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Objectives. To build and validate random forest (RF) models for the classification of bone tumors based on the conventional radiographic features of the lesion and patients’ clinical characteristics, and identify the most essential features for the classification of bone tumors. Materials and Methods. In this retrospective study, 796 patients (benign bone tumors: 412 cases, malignant bone tumors: 215 cases, intermediate bone tumors: 169 cases) with pathologically confirmed bone tumors from Nanfang Hospital of Southern Medical University, Foshan Hospital of TCM, and University of Hong Kong-Shenzhen Hospital were enrolled. RF models were built to classify tumors as benign, malignant, or intermediate based on conventional radiographic features and potentially relevant clinical characteristics extracted by three musculoskeletal radiologists with ten years of experience. SHapley Additive exPlanations (SHAP) was used to identify the most essential features for the classification of bone tumors. The diagnostic performance of the RF models was quantified using receiver operating characteristic (ROC) curves. Results. The features extracted by the three radiologists had a satisfactory agreement and the minimum intraclass correlation coefficient (ICC) was 0.761 (CI: 0.686-0.824, P < .001 ). The binary and tertiary models were built to classify tumors as benign, malignant, or intermediate based on the imaging and clinical features from 627 and 796 patients. The AUC of the binary (19 variables) and tertiary (22 variables) models were 0.97 and 0.94, respectively. The accuracy of binary and tertiary models were 94.71% and 82.77%, respectively. In descending order, the most important features influencing classification in the binary model were margin, cortex involvement, and the pattern of bone destruction, and the most important features in the tertiary model were margin, high-density components, and cortex involvement. Conclusions. This study developed interpretable models to classify bone tumors with great performance. These should allow radiographers to identify imaging features that are important for the classification of bone tumors in the clinical setting.

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Stellenwert der Radiologie in der Diagnostik der Knochensarkome

Cited by 3 publications

References 35 publications

Delay in Diagnosis and Treatment of Primary Bone Tumors during COVID-19 Pandemic in Poland

Delay in Diagnosis and Treatment of Primary Bone Tumors during COVID-19 Pandemic in Poland

Konventionelles epiphysäres Chondrosarkom des Kindes- und Jugendalters: ein Fallbericht

Using Machine Learning to Unravel the Value of Radiographic Features for the Classification of Bone Tumors

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