Stem‐cell based soft tissue substitutes: Engineering of crosslinked polylysine‐hyaluronic acid microspheres ladened with gingival mesenchymal stem cells for collagen tissue regeneration and angiogenesis

Ni, Jing; Li, Mengdi; Li, Chaolun; Zhong, Zhe; Xi, Hongwei; Wu, Yiqun

doi:10.1002/jper.22-0747

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…In the modification of HA, it can be processed into various forms, such as films, , microspheres, , sponges, , and microneedles , to meet the requirements of specific applications. Among these forms, HA microspheres with unique spherical structure and easy injection property are widely employed in drug delivery, , cell delivery, and soft tissue filling fields . The sizes and physicochemical properties of microspheres play a crucial role in drug-loading performance, drug release rates, and filling effects.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Fabrication of Monodisperse Hyaluronic Acid Microspheres with Excellent Biocompatibility and Tunable Physicochemical Properties

Long,

Ju,

Yang

et al. 2024

Ind. Eng. Chem. Res.

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A simple and efficient method based on droplet microfluidics is developed for controllably fabricating monodisperse hyaluronic acid (HA) microspheres with excellent biocompatibility and tunable physicochemical properties. By using adipic dihydrazide (ADH) as the cross-linking agent in the HA dispersed phase and 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC) as the activator in the receiving solution, chemically cross-linked HA microspheres with uniform sizes and excellent biocompatibility can be efficiently obtained in one step with the microfluidic emulsion droplets as templates. By adjusting the dimensions of the microfluidic devices as well as the flow rates of the dispersed and continuous phases, the sizes of the droplet templates and the resultant cross-linked HA microspheres can be precisely controlled. The swelling property, elasticity property, and stability of the HA microspheres can be regulated by adjusting the EDC concentrations in the receiving solutions and the mass ratios of ADH to HA in the dispersed phases. The in vitro blood compatibility and cell experiments demonstrate that the fabricated HA microspheres have excellent biocompatibility. The proposed strategy and the results in this study provide valuable guidance for the simple and efficient preparation of monodisperse HA microspheres with excellent biocompatibility and tunable physicochemical properties, which are highly desired for various applications.

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Section: Introductionmentioning

confidence: 99%

Microfluidic Fabrication of Monodisperse Hyaluronic Acid Microspheres with Excellent Biocompatibility and Tunable Physicochemical Properties

Long,

Ju,

Yang

et al. 2024

Ind. Eng. Chem. Res.

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Genesis of an ecofriendly An + B3 hyperbranched polyester from Poly (ethylene glycol) and aconitic acid for application as flocculant

Dutta,

Chakraborty,

Sengupta

et al. 2024

J Polym Res

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Polylysine in biomedical applications: from composites to breakthroughs

Deepak,

Hilaj,

Singh

et al. 2024

Biomed. Mater.

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Polylysine-based composites have emerged as promising materials in biomedical applications due to their versatility, biocompatibility, and tunable properties. In drug delivery, polylysine-based composites furnish a novel platform for targeted and controlled release of therapeutic agents. Their high loading capacity and capability to encapsulate diverse drugs make them ideal candidates for addressing challenges such as drug stability and controlled release kinetics. Additionally, their biocompatibility ensures minimal cytotoxicity, vital for biomedical applications. They also hold substantial potential in tissue engineering by providing a scaffold with tunable mechanical characteristics and surface properties, and can support cell adhesion, proliferation, and differentiation. Furthermore, their bioactive nature facilitates cellular interactions, promoting tissue regeneration and integration. Wound healing is another area where polylysine-based composites show promise. Their antimicrobial properties help prevent infections, while their ability to foster cell migration and proliferation accelerates the wound healing procedure. Incorporation of growth factors or other bioactive molecules further enhances their therapeutic effectiveness. In biosensing applications, they serve as robust substrates for immobilizing biomolecules and sensing elements. Their high surface area-to-volume ratio and excellent biocompatibility improve sensor sensitivity and selectivity, enabling accurate detection of biomarkers or analytes in biological samples. Polylysine-based composites offer potential as contrast agents in bioimaging, aiding in diagnosis and monitoring of diseases.Overall, polylysine-based composites represent a versatile platform with diverse applications in biomedical research and clinical practice, holding great promise for addressing various healthcare challenges.

show abstract

Stem‐cell based soft tissue substitutes: Engineering of crosslinked polylysine‐hyaluronic acid microspheres ladened with gingival mesenchymal stem cells for collagen tissue regeneration and angiogenesis

Cited by 4 publications

References 37 publications

Microfluidic Fabrication of Monodisperse Hyaluronic Acid Microspheres with Excellent Biocompatibility and Tunable Physicochemical Properties

Microfluidic Fabrication of Monodisperse Hyaluronic Acid Microspheres with Excellent Biocompatibility and Tunable Physicochemical Properties

Genesis of an ecofriendly An + B3 hyperbranched polyester from Poly (ethylene glycol) and aconitic acid for application as flocculant

Polylysine in biomedical applications: from composites to breakthroughs

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