Stem cell membrane-coated isotretinoin for acne treatment

Abstract

Background: Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong transdermal ability. Results: In a rabbit model of hyperkeratinization, STCM-ATRA-NPs showed significant therapeutic efficacy. By contrast, negative therapeutic efficacy was observed in a golden hamster model of hyper sebum production. Scanning electron microscopy and Fourier transform infrared spectral analyses showed that nanoparticles could penetrate the stratum corneum. Western blotting demonstrated that the nanoparticles could enhance the transdermal efficacy of isotretinoin by reducing the effect of keratin and tight junction proteins. Further, nanoparticles enhanced endocytosis, thereby promoting drug penetration and absorption into the skin. Conclusion: STCM-ATRA-NPs were demonstrated to control isotretinoin release, reducing its side effects, and efficiently permeating through the skin by reducing the effect of keratin and tight junction proteins and enhancing endocytosis.

Cell-derived extracellular vesicles and membranes for tissue repair

“…These stem cell-like microparticles (MPs) exhibited similar surface antigens and secretomes to those of genuine stem cells. They could promote cardiomyocyte functions and showed cryopreservation and stability with lyophilization and could also avoid the tumorigenicity and immunogenicity risks of living stem cell transplantation [100]. Direct injection of these MPs in an animal model of acute MI could promote angiogenesis and alleviate ventricle remodelling.…”

Correction to: Stem cell membrane-coated isotretinoin for acne treatment

“…Following publication of our article [ 1 ] the authors found that some of the images in the publication had been misused, so that three images presented at high magnification did not correspond to those at low magnification. The correct images for Figure 3b, Figure 4 (Treatment efficiency on hyper keratinization model by H&E staining—Group Blank H&E × 40) and Figure 7a are shown below.…”

Minoxidil delivered via a stem cell membrane delivery controlled release system promotes hair growth in C57BL/6J mice

“…Small particle size facilitates dermal drug delivery, penetrates deeper into the skin, and improves transdermal transport into and across the skin barrier for enhanced transdermal transport ( Alvarez-Román et al, 2004 ; Ji et al, 2021 ). Our preliminary research found that cell membrane drug-carrying technology could be used to modify nanoparticles (NPs) so that they gain the functions and properties unique to cell membranes, improving their biocompatibility and targeting, with good transdermal, low irritation, and slow release properties ( Wang et al, 2020 ).…”