Stem Cell Therapy for Autism

Ichim, Thomas E.; Solano, Fabio; Glenn, Eduardo; Morales, Frank; Smith, Leonard; Zabrecky, George; Riordan, Neil H

doi:10.1186/1479-5876-5-30

Cited by 64 publications

(49 citation statements)

References 125 publications

(106 reference statements)

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“…Other diseases in which conventional immunosuppressive therapies fail may provide a rationale for the use of MSC-based therapeutic approaches [66][67][68]. MSC infusions may also play an important role in regulating inflammatory diseases of the central nervous system, although their interactions with the blood brain barrier have not been fully elucidated [67,69,70].…”

Section: Clinical Impressions and Future Implicationsmentioning

confidence: 99%

The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

Borjesson

Peroni

2011

Clinics in Laboratory Medicine

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Section: Clinical Impressions and Future Implicationsmentioning

confidence: 99%

The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

Borjesson

Peroni

2011

Clinics in Laboratory Medicine

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“…18 These pathologies affect the brain function and plasticity and could be responsible for the impaired cognition, behaviour, language and communication, social interaction, etc in autism.…”

Section: Discussionmentioning

confidence: 99%

A Case of Autism Showing Clinical Improvements after Cellular Therapy along with PET CT Evidence

Sharma

Gokulch

Sane

et al. 2017

JSRT

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On the Indian Scale for Assessment of Autism (ISAA), his score was 98, while his Childhood Autism Rating Scale (CARS) and Functional Independence Measure (WeeFIM) scores were 28.5 (ASD) and 80, respectively. MRI of the brain and EEG were normal. PET CT scan of the brain revealed hypometabolism in the bilateral cerebellar hemispheres and hypermetabolism in frontal, parietal and temporal lobes. AbstractAutism is a complex neurodevelopmental disorder defined by a triad of deficits including impaired social interaction, communication and behaviour. With greater understanding of mechanism of action of cellular therapy it is now possible to address the pathology of autism. Here is a case of a six and a half year old boy with autism who was administered autologous bone marrow mononuclear cells (BMMNCs) intrathecally followed by an intensive rehabilitation program. On follow up at 3months and 7months post intervention, he showed significant symptomatic improvements with no major side effects. At the end of 7months, ISAA score improved from 98 to 81. The Wee FIM showed improvement 80 to 89.1. CARS score reduced from 28.5 (mild to moderate autism) to 23.5 (mild autism). PET CT scan of the brain performed pre intervention and seven months post showed a balancing effect in the metabolism of affected areas. It also showed reduction in hypermetabolism of the frontal, parietal and temporal lobe bilaterally and increase in metabolism of the previously hypometabolic bilateral cerebelli. The changes observed on the PET CT scan of the brain correlated with clinical improvements. We hypothesize that cellular therapy holds great potential as a treatment modality for autism in combination with standard rehabilitation therapy. Randomized controlled trials are warranted to study their long term effects in treating autism.

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“…From our latest clinical experience we have learnt that precursor stem cell (PSC) therapy is capable of brining improvements not only in early childhood, as it was previously thought, but also in adults with autism, who were not treated timely in the past [24,25].…”

Section: Integrative Therapeutic Protocol For Autism and Asd New Promentioning

confidence: 99%

Pathogenetically based integrative therapeutic strategies in management of autism spectrum disorders

Klokol¹,

Chan²,

Wong³

et al. 2017

J Stem Cell Res Med

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Autism and Autism spectrum disorders are the neurodevelopmental conditions characterized by persistent deficits in social communication and restricted repetitive behaviors. In spite of its occurrence being increasing from year to year, until now there is no unified opinion about etiology and pathogenesis of ASD. There is no widely accepted medical treatment for ASD as well. Authors summarized relevant data on the etiology of ASD, radiological findings in brain that persistent in autistic individuals, and proposed a pathogenetically based treatment protocol that implements a holistic integrative approach. The article summarizes therapeutic protocols proposed for complementary therapy of ASD that includes biomolecular therapies, immunotherapy, physiotherapy, speech therapy, nutrition and psychological support.

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Stem Cell Therapy for Autism

Cited by 64 publications

References 125 publications

The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

A Case of Autism Showing Clinical Improvements after Cellular Therapy along with PET CT Evidence

Pathogenetically based integrative therapeutic strategies in management of autism spectrum disorders

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