Stem cell therapy for heart failure: Ensuring regenerative proficiency

Terzic, André; Behfar, Atta

doi:10.1016/j.tcm.2016.01.003

Cited by 71 publications

(67 citation statements)

References 76 publications

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“…Catechins and polyphenols have some antiapoptotic activity through the PI3K/Akt signaling pathway and should be considered as complementary treatments [59]. Cardiac stem cell therapy either stimulating cardiac progenitors or by local or systemic infusion of autologous or heterologous stem cells is a promising therapy [60,61].…”

Section: Future Perspectivesmentioning

confidence: 99%

Alcoholic Cardiomyopathy: Old and New Insights

Fernández‐Solà¹,

Riba²

2017

J Alcohol Drug Depend

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Alcohol cardiomyopathy (ACM) is a chronic dilated heart disease with decreased left ventricular ejection fraction that may be detected in one-fourth of high-dose alcohol consumers. It causes progressive diastolic and systolic dysfunction, supra and ventricular arrhythmias leading to heart failure and increased mortality. The main etiological factor for ACM is ethanol consumption that affects the myocardium in a dose-dependent manner. The mechanisms of ACM are diverse, synchronic and synergistic. Alcohol alters the channel and receptor structure of the cell membrane, decreases intracellular calcium transients, increases oxidative and inflammatory damage, decreases structural protein synthesis and interferes with excitation-contraction coupling mechanisms. Subjects with excessive alcohol consumption may have a subclinical cardiomyopathy with atrial and LV diastolic dysfunction measured by echocardiography or cardiac MR. Subclinical LV dysfunction may progress and later appear clinical features of heart failure. Cardiac myocytes adapt to ethanol aggression by cell and nuclear hypertrophy and dilatation of heart chambers. Progressive myocyte structure disarray and apoptosis produce myocyte loss, hypertrophy of the remaining cells, subendocardial and interstitial fibrosis and low-degree myocyte regeneration. In addition, ethanol also interferes with cardiac repair and adaptation mechanisms. Thus, local cardiomyokines (FGF-21) and growth factors (myostatin, IGF-1, leptin) are modified by ethanol, limiting cardiac remodeling and myocyte regeneration, and leading to abnormal hypertrophy and eccentric ventricle dilatation. This imbalance between aggression and protection mechanisms induces progressive myocyte loss and heart dysfunction. Alcohol abstention is the main goal in ACM, although control drinking (<-60 g/day) may allow recovery of LV function. Monitoring of systemic mediated alcohol-damage, and correction of vitamin and ion deficiencies is needed. Heart failure in ACM should be treated similar to other dilated cardiomyopathies. Heart transplantation is limited to subjects without other organ damage who are able to abstain from alcohol. New preventive and therapeutic strategies are under development to decrease alcohol-mediated myocyte damage and increase heart protective and repair mechanisms.

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Section: Future Perspectivesmentioning

confidence: 99%

Alcoholic Cardiomyopathy: Old and New Insights

Fernández‐Solà¹,

Riba²

2017

J Alcohol Drug Depend

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“…Stem cell therapy has been a long pursued strategy in cardiovascular regenerative medicine to counteract cardiomyocyte loss upon MI [87,88]. Efforts to improve myocardial regeneration through stem cell therapy have focused on three major aspects: i) promote stem cell commitment towards cardiac differentiation, ii) ensure exogenous stem cell Remarkably, autophagy appears to be relevant to all of these specific approaches ( Figure 2).…”

Section: Therapeutic Potential Of Autophagy Upon Myocardial Infarctionmentioning

confidence: 99%

Therapeutic targeting of autophagy in myocardial infarction and heart failure

Riquelme

Chávez

Mondaca‐Ruff

et al. 2016

Expert Review of Cardiovascular Therapy

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PubMed searches were performed to discuss the current state of the art regarding the role of autophagy in MI and HF. We review available and potential approaches to modulate autophagy from a pharmacological and genetic perspective. We also discuss the targeting of autophagy in myocardial regeneration. Expert commentary: The targeting of autophagy has potential for the treatment of MI and HF. Autophagy is a process that takes place in virtually all cells of the body and thus, in order to evaluate this therapeutic approach in clinical trials, strategies that specifically target this process in the myocardium is required to avoid unwanted effects in other organs.

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“…[1] This complex interplay challenges established good manufacturing practices, as standards and analytical tools to measure regenerative potency are missing. [2] That is, we can build the product right, but we do not know if we are building the right product.…”

Section: Introductionmentioning

confidence: 99%

“…Here, we suggest that organ-chips, biomimetic in-vitro phenotyping platforms,[3,4] can serve as key quality assurance systems in regenerative medicine. [1,2,5]…”

Section: Introductionmentioning

confidence: 99%

Organ Chips: Quality Assurance Systems in Regenerative Medicine

Pasqualini

Emmert

Parker

et al. 2016

Clin Pharma and Therapeutics

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A class of novel therapies leverages regenerative cell types in disease microenvironments. This complex interplay challenges established good manufacturing practices, as standards and analytical tools to measure regenerative potency are missing. That is, we can build the product right, but we do not know if we are building the right product. Here, we suggest that organ‐chips, biomimetic in vitro phenotyping platforms, can serve as key quality assurance systems in regenerative medicine.

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Stem cell therapy for heart failure: Ensuring regenerative proficiency

Cited by 71 publications

References 76 publications

Alcoholic Cardiomyopathy: Old and New Insights

Alcoholic Cardiomyopathy: Old and New Insights

Therapeutic targeting of autophagy in myocardial infarction and heart failure

Organ Chips: Quality Assurance Systems in Regenerative Medicine

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