Stem Cell Therapy Improves the Outcome of Liver Resection in Cirrhotics

Ismail, Alaa; Fouad, Ossama; Abdelnasser, Amr; Chowdhury, Andaleeb; Selim, Abdulhafez

doi:10.1007/s12029-009-9092-9

Cited by 35 publications

(21 citation statements)

References 18 publications

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“…Orthotopic liver transplantation (OLT) is the therapy used as a last resort following the failure of medical management (18,19). Apart from OLT, stem cell transplantation, with the characteristics of simplicity, flexibility and fewer side-effects on the patients, has become another effective means of treating liver failure in recent years (20–22).…”

Section: Discussionmentioning

confidence: 99%

Effect of bone marrow mesenchymal stem cell transplantation on acute hepatic failure in rats

Yuan

Jiang

Zheng

et al. 2014

Experimental and Therapeutic Medicine

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The aim of the present study was to investigate the effectiveness of bone marrow mesenchymal stem cell (BMSC) transplantation in the treatment of acute hepatic failure (AHF) in rats. BMSCs were isolated from rat bone marrow, cultured and analyzed by flow cytometry. Following BMSC transplantation into rats with AHF, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), direct bilirubin (DBIL) and indirect bilirubin (IBIL) in the serum were measured using an automatic biochemical analyzer. Hematoxylin and eosin (H&E) staining and a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay were performed to analyze the pathological changes and apoptosis rate. Levels of cluster of differentiation (CD)163 and interleukin (IL)-10 in the serum and liver tissue were detected by an enzyme-linked immunosorbent assay (ELISA) assay and western blot analysis. Compared with the levels in the control group, the serum levels of ALT, AST, DBIL, IBIL, CD163 and IL-10 in the BMSC transplantation groups were significantly lower at 120 and 168 h, while the serum levels of ALB were significantly higher at 168 h after BMSC transplantation. The pathological features of liver failure were alleviated by BMSC transplantation. The expression levels of CD163 and IL-10 in the liver tissue were also significantly decreased following transplantation. The results indicate that BMSCs have a therapeutic effect on AHF in rats, and CD163 and IL-10 may be used as sensitive serum prognosis indicators in the early assessment of patients following liver transplantation.

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Section: Discussionmentioning

confidence: 99%

Effect of bone marrow mesenchymal stem cell transplantation on acute hepatic failure in rats

Yuan

Jiang

Zheng

et al. 2014

Experimental and Therapeutic Medicine

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“…Infusion of unsorted autologous bone marrow stem cells through the portal vein and hepatic artery in patients with cirrhosis, showed an improvement in ChildPugh score and albumin levels [16,37]. A significant increase of liver function in cirrhotic and hepatocellular carcinoma patients was observed following autologous bone marrow stem cell transplantation prior to surgery [38]. However, use of unsorted bone marrow stem cells or MSCs must be treated with caution as these cells can also differentiate into myofibroblasts which are the scar forming cells of the liver [39].…”

Section: Haematopoietic Stem Cells (Hscs) and Mesenchymal Stem Cells mentioning

confidence: 95%

Cell Based Therapy for Chronic Liver Disease: Role of Fetal Liver Cells in Restoration of the Liver Cell Functions

Tripura¹,

Khan²,

Pande³

2012

Liver Regeneration

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“…In these cases, intraportal administration of autologous CD133(+) bone marrow-derived stem cells after portal venous embolization of several liver segments has been shown to increase proliferation rates and FLR volume [125,126]. Similarly, stem cell therapy prior to surgical liver resection may result in significant improvement in liver function parameters, as well as a decrease in post-operative complications [127]. Potentially, cell therapy could be used to replace or repair liver tissue damaged not only by surgery, but also by radiation or chemotherapy.…”

Section: Potential Applications Of Stem Cells In Liver Diseasesmentioning

confidence: 99%

Stem Cell Therapies for Treatment of Liver Disease

et al. 2016

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Cell therapy is an emerging form of treatment for several liver diseases, but is limited by the availability of donor livers. Stem cells hold promise as an alternative to the use of primary hepatocytes. We performed an exhaustive review of the literature, with a focus on the latest studies involving the use of stem cells for the treatment of liver disease. Stem cells can be harvested from a number of sources, or can be generated from somatic cells to create induced pluripotent stem cells (iPSCs). Different cell lines have been used experimentally to support liver function and treat inherited metabolic disorders, acute liver failure, cirrhosis, liver cancer, and small-for-size liver transplantations. Cell-based therapeutics may involve gene therapy, cell transplantation, bioartificial liver devices, or bioengineered organs. Research in this field is still very active. Stem cell therapy may, in the future, be used as a bridge to either liver transplantation or endogenous liver regeneration, but efficient differentiation and production protocols must be developed and safety must be demonstrated before it can be applied to clinical practice.

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Stem Cell Therapy Improves the Outcome of Liver Resection in Cirrhotics

Abstract: In conclusion, autologous stem cell therapy can improve the surgical outcome in cirrhotic livers and should be considered as an adjuvant treatment in such patients undergoing hepatic resection.

Cited by 35 publications

References 18 publications

Effect of bone marrow mesenchymal stem cell transplantation on acute hepatic failure in rats

Effect of bone marrow mesenchymal stem cell transplantation on acute hepatic failure in rats

Cell Based Therapy for Chronic Liver Disease: Role of Fetal Liver Cells in Restoration of the Liver Cell Functions

Stem Cell Therapies for Treatment of Liver Disease

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