Stem cell therapy: old challenges and new solutions

Balistreri, Carmela Rita; Falco, Elena De; Bordin, Antonella; Maslova, O.O.; Koliada, Alexander; Vaiserman, Alexander

doi:10.1007/s11033-020-05353-2

Cited by 25 publications

(19 citation statements)

References 125 publications

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“…This concept may appear extreme, but the idea, to manipulate ageing as other non-fundamental life's processes, increases. Consequently, age-associated senescence may appear as a complex of pathophysiological processes that could be prevented, delayed, or even reversed ( Balistreri, 2018 ; Balistreri et al., 2020 ; Vaiserman et al., 2019 ). At present, novel biotechnologies, particularly including omics procedures (i.e., genomics, transcriptomics, proteomics, and metabolomics) have emergently applied in the research and potentially result capable to slow-down or postpone processes related to ageing, and consequently to be widely applied in anti-ageing medicine ( Balistreri, 2018 ; Balistreri et al., 2020 ; Vaiserman et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, age-associated senescence may appear as a complex of pathophysiological processes that could be prevented, delayed, or even reversed ( Balistreri, 2018 ; Balistreri et al., 2020 ; Vaiserman et al., 2019 ). At present, novel biotechnologies, particularly including omics procedures (i.e., genomics, transcriptomics, proteomics, and metabolomics) have emergently applied in the research and potentially result capable to slow-down or postpone processes related to ageing, and consequently to be widely applied in anti-ageing medicine ( Balistreri, 2018 ; Balistreri et al., 2020 ; Vaiserman et al., 2019 ). On the other hand, such technologies have been used for identifying the molecular and cellular mechanisms related to ageing process, including genomic instability, epigenetic deregulation, loss of proteostasis, mitochondrial dysfunction, cellular senescence, exhaustion of stem cells, inflammation, telomere shortening, autophagy, impaired stress resistance and deregulated nutrient signaling ( Balistreri, 2018 ; Balistreri et al., 2020 ; Vaiserman et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?

Balistreri

Madonna

Ferdinándy

2021

Current Research in Pharmacology and Drug Discovery

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It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particular interest is a new branch of the medical science , called anti-ageing medicine since CVD are the result of cardiovascular ageing. Senescent cells (SC) accumulate in cardiovascular system contributing to the onset of typical age-related cardiovascular conditions (i.e., atherosclerosis, medial aorta degeneration, vascular remodeling, stiffness). Such conditions progress in cardiovascular pathologies (i.e., heart failure, coronary artery disease, myocardial infarction, and aneurysms) by evocating the production of a proinflammatory and profibrotic senescence-associated secretory phenotype (SASP). Consequently, therapies able to specifically eliminate SC are in developing. The senotherapeutics represents an emerging anti-SC treatment, and comprises three therapeutic approaches: (a) molecules to selectively kill SC, defined senolytics ; (b) compounds able in reducing evocated SC SASP, acting hence as SASP suppressors, or capable to change the senescent phenotype, called senomorphics ; (c) inhibition of increase of the number of SC in the tissues. Here, it describes them and the emerging data about current investigations on their potential clinical application in CVD, stressing benefits and limitations, and suggesting potential solutions for applying them in near future as effective anti-CVD treatments.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?

Balistreri

Madonna

Ferdinándy

2021

Current Research in Pharmacology and Drug Discovery

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“…In particular, compared with other stem cells, adipose-derived stem cells (ADSCs) have a wide range of easily obtained donors, fast expansion, low immunogenicity, minimally invasive extraction and signi cant proliferative capacity [12]. In addition, the ADSCs can produce and secrete various growth factors, such as vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), transforming growth factor-β (TGF-β), and broblast growth factor (FGF) [13]. Therefore, ADSCs have recently been proposed as a potential dominant cell for treating burn wounds [14][15][16].…”

Section: Intoductionmentioning

confidence: 99%

Injectable Small Intestinal Submucosa and Adipose-Derived Stem Cells Composite Gel Promoting The Deep Partial-Thickness Burns Repair

Guo¹,

Guo²,

Zhou³

et al. 2021

Preprint

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Backgroud: Burns wound treatment remains a significant clinical challenge around the world. Although stem cell-based scaffold therapies are promising strategy for burn wounds, its clinical therapeutic effect is still not satisfactory nowadays. Herein the aim of this study is to evaluate the therapeutic efficacy of injectable small intestinal submucosa (SIS) and rat adipose-derived mesenchymal stem cells (ADSCs) composite gel to repair the deep partial thickness burns in rats. Methods The deep partial-thickness burns model in rats were made by contacting the dorsal surface SIS memberance directly with boiled water for 10 seconds. After scalding, the wound edge and the central area were injected for phosphate-buffered saline (PBS) solution, ADSCs, injectable SIS and injectable SIS/ ADSCs composite gel, respectively. At 3, 7, 14 and 21 days post injection treatment, the burn wound closure percentages were evaluated. Moreover, micro-vascular density and epidermal thickness assessment in burn wound were performed by histopathology examination or immunofluorescence. Besides, the expression of genes related to wound angiogenesis and re-epithelialization were determined in vitro. Results Our data revealed that that injectable SIS gel could provide a well-grown microenvironment for ADSCs in vitro, and the ADSCs-SIS composite gel could synergistically promote the deep partial-thickness burn repair via paracrine and differentiation mechanisms. Conclusions Taken together, this study shows the ADSCs-SIS composite gel is a promising candidate for burn wound regeneration.

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“…Stem cells are primal cells that are mutual to all multicellular organisms and can renew themselves through cell divisions, and differentiate into a wide range of specialized cell types [ 1 ].One of the main challenges for using therapeutic effects of stem cells is how to direct their differentiation process, decrease the immune rejection, and mitigate the risk of tumors derived from the transplanted stem cells [ 2 ]. To tackle these problems some novel technological interventions were proposed, for example, genetic modification of the stem cells, 3-dimensional bioprinting of the stem cells, and the addition of nanocomposites [ 3 ]. Numerous papers have been published discussing the ways to get stem cell therapy involved in the current treatment protocols of disease that might benefit from this method.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review

Ebrahimi

Ahmadi

Ghasrodashti

et al. 2021

Bosn J of Basic Med Sci

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Stem cell therapy has been used to treat several types of diseases, and it is expected that its therapeutic uses shall increase as novel lines of evidence begin to appear. Furthermore, stem cells have the potential to make new tissues and organs. Thus, some scientists propose that organ transplantation will significantly rely on stem cell technology and organogenesis in the future. Stem cells and its robust potential to differentiate into specific types of cells and regenerate tissues and body organs, have been investigated by numerous clinician scientists and researchers for their therapeutic effects. Degenerative diseases in different organs have been the main target of stem cell therapy. Neurodegenerative diseases such as Alzheimer's, musculoskeletal diseases such as osteoarthritis, congenital cardiovascular diseases, and blood cell diseases such as leukemia are among the health conditions that have benefited from stem cell therapy advancements. One of the most challenging parts of the process of incorporating stem cells into clinical practice is controlling their division and differentiation potentials. Sometimes, their potential for uncontrolled growth will make these cells tumorigenic. Another caveat in this process is the ability to control the differentiation process. While stem cells can easily differentiate into a wide variety of cells, a paracrine effect controlled activity, being in an appropriate medium will cause abnormal differentiation leading to treatment failure. In this review, we aim to provide an overview of the therapeutic effects of stem cells in diseases of various organ systems. In order to advance this new treatment to its full potential, researchers should focus on establishing methods to control the differentiation process, while policymakers should take an active role in providing adequate facilities and equipment for these projects. Large population clinical trials are a necessary tool that will help build trust in this method. Moreover, improving social awareness about the advantages and adverse effects of stem cell therapy is required to develop a rational demand in the society, and consequently, healthcare systems should consider established stem cell-based therapeutic methods in their treatment algorithms.

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Stem cell therapy: old challenges and new solutions

Cited by 25 publications

References 125 publications

Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?

Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?

Injectable Small Intestinal Submucosa and Adipose-Derived Stem Cells Composite Gel Promoting The Deep Partial-Thickness Burns Repair

Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review

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