Stem Cell Update: Highlights from the 2010 Lugano Stem Cell Meeting

Bardelli, Silvana; Astori, Giuseppe; Sürder, Daniel; Tallone, Tiziano; Terzic, André; Soldati, Gianni; Moccetti, Tiziano

doi:10.1007/s12265-010-9232-4

Cited by 1 publication

(1 citation statement)

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“…Once renowned for exclusive private clinic treatments and the magistral preparation of cell-based therapeutic products, Switzerland has been following modern regulatory adaptations to better control the overall quality, safety, and clinical use of specific biological products [ 4 ]. Therefore, the official therapeutic use of living cells in particular has been technically restricted in the past two decades to Swiss national university centers and public hospitals, with some private stakeholders notably focusing on specific blood-derived or stem-cell-based applications [ 7 , 8 ]. Notable current clinical applications of therapeutic cell-based preparations in Switzerland therefore comprise platelet-rich plasma (i.e., for burns, Centre Hospitalier Universitaire Vaudois(CHUV), Lausanne, and others), chimeric antigen receptor (CAR-T) cells or autologous tumor-infiltrating lymphocytes enriched for tumor antigen specificity (i.e., for solid tumors in oncology, CHUV, Lausanne), autologous chondrocytes for osteoarthritis of the knee (Hôpitaux Universitaires de Genève (HUG), Geneva, and others), or pancreatic Langerhans islet transplantation (i.e., for diabetes, HUG, Geneva).…”

Section: Introductionmentioning

confidence: 99%

Back to the Cradle of Cytotherapy: Integrating a Century of Clinical Research and Biotechnology-Based Manufacturing for Modern Tissue-Specific Cellular Treatments in Switzerland

et al. 2021

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Empirically studied by Dr. Brown-Séquard in the late 1800s, cytotherapies were later democratized by Dr. Niehans during the twentieth century in Western Switzerland. Many local cultural landmarks around the Léman Riviera are reminiscent of the inception of such cell-based treatments. Despite the discreet extravagance of the remaining heirs of “living cell therapy” and specific enforcements by Swiss health authorities, current interest in modern and scientifically sound cell-based regenerative medicine has never been stronger. Respective progress made in bioengineering and in biotechnology have enabled the clinical implementation of modern cell-based therapeutic treatments within updated medical and regulatory frameworks. Notably, the Swiss progenitor cell transplantation program has enabled the gathering of two decades of clinical experience in Lausanne for the therapeutic management of cutaneous and musculoskeletal affections, using homologous allogeneic cell-based approaches. While striking conceptual similarities exist between the respective works of the fathers of cytotherapy and of modern highly specialized clinicians, major and important iterative updates have been implemented, centered on product quality and risk-analysis-based patient safety insurance. This perspective article highlights some historical similarities and major evolutive differences, particularly regarding product safety and quality issues, characterizing the use of cell-based therapies in Switzerland over the past century. We outline the vast therapeutic potential to be harnessed for the benefit of overall patient health and the importance of specific scientific methodological aspects.

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Section: Introductionmentioning

confidence: 99%