1994
DOI: 10.1038/eye.1994.42
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Stem cells and corneal epithelial regeneration

Abstract: SUMMARYSelf-renewing tissues such as the corneal epithelium con tain stem cells which represent the proliferative reserve.

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Cited by 144 publications
(70 citation statements)
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“…In the region of limbal palisades, LESCs are in contact with a loose stroma without an intervening Bowmans' layer, thus, direct interaction of epithelial and stromal cells is possible. In the basal layers of the interpalisade rete ridges, small, round cells, exhibiting morphological features of primitive stem cells were shown (16,38,100,101). Protection of stem cells is thought to be fulfilled by three attributes of the palisades: they are situated in those parts of the cornea that are most protected by the eyelids; they contain melanocytes that safeguard stem cells from UV radiation by the transfer of melanin granules (35,38,102,103); in addition, protection from mechanical shear forces is provided at the bottom of the rete pegs.…”
Section: The Limbal Epithelial Stem Cell Nichementioning
confidence: 99%
“…In the region of limbal palisades, LESCs are in contact with a loose stroma without an intervening Bowmans' layer, thus, direct interaction of epithelial and stromal cells is possible. In the basal layers of the interpalisade rete ridges, small, round cells, exhibiting morphological features of primitive stem cells were shown (16,38,100,101). Protection of stem cells is thought to be fulfilled by three attributes of the palisades: they are situated in those parts of the cornea that are most protected by the eyelids; they contain melanocytes that safeguard stem cells from UV radiation by the transfer of melanin granules (35,38,102,103); in addition, protection from mechanical shear forces is provided at the bottom of the rete pegs.…”
Section: The Limbal Epithelial Stem Cell Nichementioning
confidence: 99%
“…Throughout adult life, there is constant desquamation of superficial corneal epithelial cells after terminal differentiation or apoptosis (Kruse, 1994;Ren and Wilson, 1996), such that there is a need for replacement of lost cells. In early postnatal life, proliferating cells are found throughout the basal corneal epithelium (Tseng et al, 1999;Yew et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…However, as shown in Figure 1, the mass of the adult corneal epithelium is maintained by a population of stem-like cells in the basal limbal region (limbal stem cells) that continue to cycle slowly throughout life, unless stimulated to proliferate more rapidly by corneal injury (Davanger and Evensen, 1971;Cotsarelis et al, 1989). Their daughters (transit or transient amplifying cells) migrate centripetally (Kinoshita et al, 1981;Buck, 1985) into the basal layer of the corneal epithelium, where they continue to divide a small number of times (Kruse, 1994;Lehrer et al, 1998). Daughter cells appear to lose contact with the basal epithelium and differentiate synchronously in the upper layers of the cornea (Beebe and Masters, 1996).…”
Section: Introductionmentioning
confidence: 99%
“…Besides, recent progress in tissue bioengineering is rapidly contributing to the development of many types of tissues, including cornea. In the hope of making corneal substitutes more widely available for visual rehabilitation, investigations are underway in the areas of core-and-skirt keratoprostheses (Kirkham and Dangel, 1991), biosynthetic tissue replacements (Griffith and Osborne, 1999;Li et al, 2003), and thermo-responsive celldetachable substrates for corneal cell sheet engineering (Kruse, 1994;Nishida et al, 2004). Compared with synthetic polymers for artificial corneas, tissue engineering-based implants could reduce the possibility of rejection and complications arising from surgery, including bacterial infection, enzymatic degradation of surrounding tissue, and poor stabilization.…”
Section: Introductionmentioning
confidence: 99%