Stem Cells and Tissue Engineering

Pavlović, Mirjana; Balint, Bela

doi:10.1007/978-1-4614-5505-9

Cited by 26 publications

(111 citation statements)

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“…This age limitation is regrettable since SC-transplant candidates in multiple myeloma are frequently older than 60 or even 65 years 1 . The earliest SC collections from PB were accomplished in "steady state hematopoiesis" -by numerous procedures since late 1970s, and following cryopreservation was needed 1,2,16 . The cell harvesting is the same for allogeneic donors as for autologous patients.…”

Section: Sem -Standard Error Of the Meanmentioning

confidence: 99%

“…High-dose chemotherapy followed by allogeneic or autologous SC-transplants is considered as standard treatment for some malignant and few immune-mediated diseases (e.g. multiple sclerosis) [1][2][3] . The use of SCs for organ repair (damaged myocardium, liver, pancreas, etc) opens new perspectives in regenerative medicine 1,3 .…”

Section: Introductionmentioning

confidence: 99%

“…multiple sclerosis) [1][2][3] . The use of SCs for organ repair (damaged myocardium, liver, pancreas, etc) opens new perspectives in regenerative medicine 1,3 . For transplants, bone marrow (BM) has been the primary SC-source, in which approximately 2-4% of total nucleated cells (TNCs) express the CD34 antigen 4,5 .…”

Section: Introductionmentioning

confidence: 99%

“…Traditional sources of the SCs are the BM and PB. The UCB has been used as an alternative source since the late 1980s 1,13 . Damages caused by the chemotherapy (applied prior to autologous SC-transplants) could be an important limiting factor of the SC-mobilization.…”

Section: Introductionmentioning

confidence: 99%

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Relative frequency of immature CD34+/CD90+ subset in peripheral blood following mobilization correlates closely and inversely with the absolute count of harvested stem cells in multiple myeloma patients

Balint¹,

Stanojević

Todorović

et al. 2017

VOJNOSANIT PREGL

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Background/Aim. Stem cells (SCs) guarantee complete/long-term bone marrow (BM) repopulation after SCtransplants. The aim of the study was to evaluate absolute count of total SCs (determined by ISHAGE-sequential-gating protocol -SC ish ) and relative frequency of immature CD34 + /CD90 + (CD90 + SC ish ) subset in peripheral blood (PB) as predictive factors of mobilization and apheresis product (AP) quality. Methods. Mobilization included chemotherapy and granulocyte-growth-factor (G-CSF). Harvesting was performed by Spectra-Optia-IDL-system. The SCs ish were determined as a constitutional part of CD34 + cells in the "stemcell-region" using FC-500 flow-cytometer. In this study, the original ISHAGE-sequential-gating protocol was modified by introduction of anti-CD90-PE monoclonal-antibody into the analysis of CD90 expression on SC ish (CD90 + SC ish ). The results were presented as a percentage of SC ish per nucleatedcell count, absolute SC ish count in μL of the PB or the AP, percentage of the CD90 + SC ish expressed to SC ish and absolute CD90 + SC ish count in μL of the PB or the AP. Results. The absolute count of total SC ish and CD90 + SC ish was significantly higher (p = 0.0007 and p = 0.0266, respectively) in the AP than in the PB samples. The CD90 + SC ish /total SC ish indexes from PB were higher than indexes from the AP (p = 0.039). Key words: stem cells; hematopoietic stem cell transplantation; bone marrow; flow cytometry; multiple myeloma; antineoplastic combined chemotherapy protocols.Apstrakt Uvod/Cilj. Matične ćelije (MĆ) obezbeđuju kompletnu/dugotrajnu repopulaciju kostne srži (KS) posle trans-plantacije. Cilj ove studije bila je procena apsolutnog broja ukupnih MĆ (utvrđena protokolom "ISHAGE-sequentialgating" -Stem-Cell ish [SC ish ]) i relativne učestalosti primitivnih podipova CD34 + /CD90 + (CD90 + SC ish ) u perifernoj krvi (PK) Ključne reči: ćelije, matične; transplantacija hematopoeznih matičnih ćelija; kostna srž; citometrija, protočna; multipli mijelom; lečenje kombinovanjem antineoplastika, protokoli.

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Section: Sem -Standard Error Of the Meanmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relative frequency of immature CD34+/CD90+ subset in peripheral blood following mobilization correlates closely and inversely with the absolute count of harvested stem cells in multiple myeloma patients

Balint¹,

Stanojević

Todorović

et al. 2017

VOJNOSANIT PREGL

Self Cite

View full text Add to dashboard Cite

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“…Stem cells have presented a great opportunity for tissue regeneration and therapies 7 and can be obtained from various sources, such as the limbus, skin, bone marrow, oral mucosa, and many others. In 2000, a new source of stem cells was discovered in human adult tooth pulp, these are dental pulp stem cells (DPSCs).…”

mentioning

confidence: 99%