Tissue Engineering Triangle and its Development

Pavlović, Mirjana; Mayfield, John D.; Balint, Bela

doi:10.1007/978-1-4614-8495-0_11

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…34 These are growth factors (GFs), 35 stem cell (SCs), 36,37 and scaffolds, 38,39 called the triangle of tissue engineering. 40 Using a combination of these factors, scientists have been always looking for best strategies to develop safer and more cost-effective approaches for faster wound regeneration and repair. 39,41 Generally, efforts in wound healing have fallen into the following classes:…”

Section: Introductionmentioning

confidence: 99%

Regeneration and Repair of Skin Wounds: Various Strategies for Treatment

Rezaie

Momeni-Moghaddam

Naderi‐Meshkin

2019

The International Journal of Lower Extremity Wounds

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Skin as a mechanical barrier between the inner and outer environment of our body protects us against infection and electrolyte loss. This organ consists of 3 layers: the epidermis, dermis, and hypodermis. Any disruption in the integrity of skin leads to the formation of wounds, which are divided into 2 main categories: acute wounds and chronic wounds. Generally, acute wounds heal relatively faster. In contrast to acute wounds, closure of chronic wounds is delayed by 3 months after the initial insult. Treatment of chronic wounds has been one of the most challenging issues in the field of regenerative medicine, promoting scientists to develop various therapeutic strategies for a fast, qualified, and most cost-effective treatment modality. Here, we reviewed more recent approaches, including the development of stem cell therapy, tissue-engineered skin substitutes, and skin equivalents, for the healing of complex wounds.

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Section: Introductionmentioning

confidence: 99%

Regeneration and Repair of Skin Wounds: Various Strategies for Treatment

Rezaie

Momeni-Moghaddam

Naderi‐Meshkin

2019

The International Journal of Lower Extremity Wounds

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Biomaterials Act as Enhancers of Growth Factors in Bone Regeneration

Chen

Wang

Liu

2016

Adv Funct Materials

101

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Inspired by the physiological events of the “wound healing cascade”, the integration of biomaterials and growth factors is generally accepted as an emerging and powerful strategy for bone regenerative therapy. As a type of biological mediator, growth factors play a key role in functional bone regeneration. In this review, recent progress in the enhancement of bone‐related growth factors via a biomaterial strategy will be discussed. Two main reinforcing mechanisms, temporal regulation and efficacy manipulation, are described in detail, highlighting the potential capability of biomaterials to harness the interactions between growth factors and specific cells. The effects of biomaterials for promoting bone formation via growth factor‐mediated osteogenesis are further elucidated. Finally, an outlook of the prospects in terms of superior communication among growth factors, cells, and biomaterials in the microenvironment is presented, which might provide new directions for the design of medical devices for bone regeneration.

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