Stem cells for neonatal brain injury – Lessons from the bench

Ahn, So Yoon; Chang, Yun Sil; Park, Won Soon

doi:10.1016/j.semperi.2023.151726

Cited by 5 publications

(1 citation statement)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future studies should focus on the different routes of administration of hydrogen as well as the effects on brain damage and the main mechanisms of hydrogen neuroprotection. Mesenchymal stem cells (MSCs) have potent anti-inflammatory and antiapoptotic properties, especially the pleiotropic neuroprotection of MSCs, [ 62 , 63 ] an experimental animal study found [ 64 ] that injection of human embryonic stem cell-derived MSCs into a mouse model resulted in some improvement in neurobehavior of the treated mice. Devyaltovskaya et al [ 65 ] reported 2 clinical cases of application of umbilical cord-derived somatic MSCs for the treatment of hypoxic-ischemic encephalopathy rehabilitation in very preterm infants (27–28 weeks of gestation, weighing 900 and 870 g, respectively), in which children were sampled at birth with umbilical cord-derived MSCs, and the cells were injected at doses of 1.6 to 7 million per kilogram (MW/kg) at the ages of 3, 6, 12 months (the first patient) and 3, 6, 9, 15 months (the second patient).…”

Section: Medicationmentioning

confidence: 99%

Current status and controversies in the treatment of neonatal hypoxic-ischemic encephalopathy: A review

Gao,

Jiang

2024

Medicine

View full text Add to dashboard Cite

Neonatal hypoxic-ischemic encephalopathy is a type of traumatic brain injury caused by insufficient cerebral perfusion and oxygen supply in the perinatal neonate, which can be accompanied by different types of long-term neurodevelopmental sequelae, such as cerebral palsy, learning disabilities, mental retardation and epilepsy It is one of the main causes of neonatal death and disability, and it has caused a great burden on families and society. Therefore, this article mainly reviews the latest developments in mild hypothermia therapy and related drugs for neonatal hypoxic-ischemic encephalopathy.

show abstract

Section: Medicationmentioning

confidence: 99%

Current status and controversies in the treatment of neonatal hypoxic-ischemic encephalopathy: A review

Gao,

Jiang

2024

Medicine

View full text Add to dashboard Cite

show abstract

Turkish Neonatal Society position paper for stem cell therapy in neonates

Cetinkaya,

Koc,

Acunas

et al. 2025

Global Pediatrics

View full text Add to dashboard Cite

Neuroserpin normalization by mesenchymal stem cell therapy after encephalopathy of prematurity in neonatal rats

Wang,

Hsiung,

Chang

et al. 2024

Pediatr Res

View full text Add to dashboard Cite

Background Hypoxic-ischemia (HI), infection/inflammation and reperfusion injury are pathogenic factors of encephalopathy of prematurity, which involves maturational/neurotrophic disturbances in oligodendrocyte progenitor cells (OPC) and neurons/axons. Mesenchymal stem cells (MSCs) might facilitate neuroserpin production, which is neurotrophic for OPC/neurons. This study investigated MSC effects on developmental disturbances after lipopolysaccharide (LPS)-sensitized HI/reperfusion (LHIR) injury and the relation to neuroserpin expression. Methods Postnatal day 2 (P2) rat pups received intraperitoneal LPS (5 µg/kg) injection followed by HI (unilateral common-carotid-artery ligation and 6.5% oxygen exposure for 90 min) and post-HI reperfusion (release of ligation). MSCs (5 × 104 cells) were injected into the left lateral ventricle at 24 h post-LHIR. Neurological tests and brain tissue examinations were performed between P5 and P56. Results After LHIR injury, MSC therapy significantly reduced cell death in subplate neurons, attenuated axonal damage, and facilitated synaptophysin synthesis in the cortex. It also alleviated OPC maturation arrest and preserved the complexity of myelinated axons in the white matter, leading to cognitive, motor and behavioral functional improvements. These beneficial effects were linked to restored neuroserpin expression in subplate neurons. Conclusions MSC therapy ameliorated developmental disturbances after LHIR injury through protection of neuroserpin expression, serving as a promising approach for treating encephalopathy of prematurity. Impact Neuroserpin is secreted by subplate neurons and may regulate the development of neurons and oligodendrocyte-axon contact for myelination in the premature brain. LPS-sensitized hypoxic-ischemia/reperfusion (LHIR) injury caused the developmental disturbances of neurons/axons and oligodendrocytes, and lowered neuroserpin levels in a neonatal rat model simulating encephalopathy of prematurity. Mesenchymal stem cell therapy alleviated the developmental disturbances after LHIR injury through protection of neuroserpin expression in subplate neurons, offering a new perspective on potential treatment for encephalopathy of prematurity.

show abstract

Stem cells for neonatal brain injury – Lessons from the bench

Cited by 5 publications

References 77 publications

Current status and controversies in the treatment of neonatal hypoxic-ischemic encephalopathy: A review

Current status and controversies in the treatment of neonatal hypoxic-ischemic encephalopathy: A review

Turkish Neonatal Society position paper for stem cell therapy in neonates

Neuroserpin normalization by mesenchymal stem cell therapy after encephalopathy of prematurity in neonatal rats

Contact Info

Product

Resources

About