Stent implantation in the superficial femoral artery: Short thrombelastometry-derived coagulation times identify patients with late in-stent restenosis

Thrombin‐Induced Platelet‐Fibrin Clot Strength Identified by Thrombelastography

“…Schoebel et al found that a hyper‐coagulable state indicated by elevated systemic prothrombin fragment 1 + 2 levels, red blood cell aggregation at low shear stress, and lower plasminogen‐activator inhibitor levels prior to intervention, characterize a group at high‐risk prone for restenosis among clinically stable coronary artery disease patients . Cvrin, et al demonstrated that a hypercoagulable state measured by short thrombelstometry‐derived coagulation times was associated with an increased risk for restenosis in patients with peripheral artery disease . Salvioni et al demonstrated that elevated fibrinopeptide A levels, an indicator of heightened thrombin activity, was observed immediately after PCI in patients who developed restenosis at 6 month as compared to patients without restenosis .…”

“…43 Cvrin, et al demonstrated that a hypercoagulable state measured by short thrombelstometry-derived coagulation times was associated with an increased risk for restenosis in patients with peripheral artery disease. 44 Salvioni et al demonstrated that elevated fibrinopeptide A levels, an indicator of heightened thrombin activity, was observed immediately after PCI in patients who developed restenosis at 6 month as compared to patients without restenosis. 45 In the current study, we have demonstrated that TEG indices of hypercoagulability such as elevated TIP-FCS, CI, and fibrinogen activity and faster speed of clot formation are associated with ISR.…”

“…Few studies in humans have examined the relation of ex vivo measurements of thrombogenicity to ISR . Hypercoagulability has been shown to be associated with an increased risk for ISR of superficial femoral artery stents . Thrombin has been reported to be a key mediator in the response to vessel wall injury and is a mitogen .…”

“…21,22 Hypercoagulability has been shown to be associated with an increased risk for ISR of superficial femoral artery stents. 23 Thrombin has been reported to be a key mediator in the response to vessel wall injury and is a mitogen. 24 As thrombogenicity measured by thrombelastography (TEG) is highly influenced by the ability of thrombin to generate tensile strength of the plateletfibrin clot, we hypothesized that analysis of thrombogenicity by TEG identifies patients with ISR.…”

Red cell distribution width in coronary heart disease: prediction of restenosis and its relationship with inflammatory markers and lipids

“…In-stent restenosis (ISR) is associated with multiple complicated pathophysiologic mechanisms, including lipid metabolic disorders, blood coagulation2 and inflammatory response 3 4. Hence, the key factors influencing ISR are important for clinical treatment and prognosis.…”