Stepwise immobilization of keratin-dopamine conjugates and gold nanoparticles on PET sheets for potential vascular graft with the catalytic generation of nitric oxide

Wang, Lijuan; Xin, Xuanxuan; Li, Pengfei; Dou, Jun; Han, Xiao; Shen, Jian; Yuan, Jiang

doi:10.1016/j.colsurfb.2021.111855

Cited by 18 publications

(11 citation statements)

References 56 publications

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“…Monitoring of the concentration of NO released from a scaffold is crucial to ensure that it is not cytotoxic or causes desensitization of the host tissue. In a human vessels, the range of NO released ranges from 0.5 to 4 × 10 –10 mol/cm 2 /min …”

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

“…In a human vessels, the range of NO released ranges from 0.5 to 4 × 10 −10 mol/cm 2 /min. 137 Another anticoagulant that has been recently used is fucoidan, which is a sulfated polysaccharide isolated from brown algae. Fucoidan has numerous biological properties, including anticoagulant, anti-inflammatory, antioxidant, antibacterial, antiviral, and anticancer properties.…”

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confidence: 99%

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Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

2022

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Small-diameter artificial vascular grafts (SDAVG) are used to bypass blood flow in arterial occlusive diseases such as coronary heart or peripheral arterial disease. However, SDAVGs are plagued by restenosis after a short while due to thrombosis and the thickening of the neointimal wall known as intimal hyperplasia (IH). The specific causes of IH have not yet been deduced; however, thrombosis formation due to bioincompatibility as well as a mismatch between the biomechanical properties of the SDAVG and the native artery has been attributed to its initiation. The main challenges that have been faced in fabricating SDAVGs are facilitating rapid re-endothelialization of the luminal surface of the SDAVG and replicating the complex viscoelastic behavior of the arteries. Recent strategies to combat IH formation have been mostly based on imitating the natural structure and function of the native artery (biomimicry). Thus, most recently, developed grafts contain a multilayered structure with a designated function for each layer. This paper reviews the current polymeric, biomimetic SDAVGs in preventing the formation of IH. The materials used in fabrication, challenges, and strategies employed to tackle IH are summarized and discussed, and we focus on the multilayered structure of current SDAVGs. Additionally, the future aspects in this area are pointed out for researchers to consider in their endeavor.

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Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

mentioning

confidence: 99%

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

2022

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“…Copper Nanoparticle 186 In addition to Cu, there are other metal elements involved in the catalytic release of NO, such as Au. 187,188 Chelate 189 Covalent bonding by polydopamine [190][191][192] Layer-by-layer assembly 193,194 Organic sulfur Covalent bonding thiolcontaining cysteine 195 This design can control the release of NO by adjusting the proportion of each component and the loading sequence.…”

Section: Endogenousmentioning

confidence: 99%

Endothelialization strategy of implant materials surface: The newest research in recent 5 years

Bian

Chen

Weng

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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In recent years, more and more metal or non-metal materials have been used in the treatment of cardiovascular diseases, but the vascular complications after transplantation are still the main factors restricting the clinical application of most grafts, such as acute thrombosis and graft restenosis. Implant materials have been extensively designed and surface optimized by researchers, but it is still too difficult to avoid complications. Natural vascular endodermis has excellent function, anti-coagulant and anti-intimal hyperplasia, and it is also the key to maintaining the homeostasis of normal vascular microenvironment. Therefore, how to promote the adhesion of endothelial cells (ECs) on the surface of cardiovascular materials to achieve endothelialization of the surface is the key to overcoming the complications after implant materialization. At present, the surface endothelialization design of materials based on materials surface science, bioactive molecules, and biological function intervention and feedback has attracted much attention. In this review, we summarize the related research on the surface modification of materials by endothelialization in recent years, and analyze the advantages and challenges of current endothelialization design ideas, explain the relationship between materials, cells, and vascular remodeling in order to find a more ideal endothelialization surface modification strategy for future researchers to meet the requirements of clinical biocompatibility of cardiovascular materials.

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“…Surface modification and biofunctionalization facilitate hemocompatibility and endothelial cell (EC) adhesion well aimed to address the abovementioned medical problems. [14][15][16] Thrombosis and restenosis seriously impact the clinical performance of stents and artificial grafts. In order to solve these problems, numerous strategies have been developed to construct hemocompatible surfaces, enhance endothelialization, and inhibit intimal hyperplasia.…”

Section: Introductionmentioning

confidence: 99%

“…Surface modification and biofunctionalization facilitate hemocompatibility and endothelial cell (EC) adhesion well aimed to address the above-mentioned medical problems. 14–16…”

Section: Introductionmentioning

confidence: 99%

Recent strategies for improving hemocompatibility and endothelialization of cardiovascular devices and inhibition of intimal hyperplasia

et al. 2022

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Stepwise immobilization of keratin-dopamine conjugates and gold nanoparticles on PET sheets for potential vascular graft with the catalytic generation of nitric oxide

Cited by 18 publications

References 56 publications

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

Endothelialization strategy of implant materials surface: The newest research in recent 5 years

Recent strategies for improving hemocompatibility and endothelialization of cardiovascular devices and inhibition of intimal hyperplasia

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