2017
DOI: 10.1016/j.msec.2017.03.170
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Stereocomplex poly(lactic acid) nanocoated chitosan microparticles for the sustained release of hydrophilic drugs

Abstract: In this work, novel chitosan based microparticles were developed by the layer-by-layer deposition of poly(lactic acid) stereocomplex films on their surface in the view of controlling the release of encapsulated hydrophilic drugs. As first step, the quartz crystal microbalance technique was used to monitor the step-by-step deposition of the stereocomplex layers onto chitosan by evaluating the deposited mass for each layer. Chitosan microparticles, with a size ranging between 40 and 90μm, were then produced by a… Show more

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Cited by 15 publications
(8 citation statements)
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“…The PXRD diffractogram of metformin revealed distinct peaks at 2θ: 12.17°, 17.62°, 24.47°, 28.2°, 31.17°, and 37.07°; these sharp peaks confirmed the highly crystalline nature of metformin. The blank microparticles showed peaks at 2θ: 16.6° and 18.92°, indicating the semi-crystalline nature of PLA [ 17 ]. The PXRD diffractogram of the microparticles showed no peaks.…”
Section: Resultsmentioning
confidence: 99%
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“…The PXRD diffractogram of metformin revealed distinct peaks at 2θ: 12.17°, 17.62°, 24.47°, 28.2°, 31.17°, and 37.07°; these sharp peaks confirmed the highly crystalline nature of metformin. The blank microparticles showed peaks at 2θ: 16.6° and 18.92°, indicating the semi-crystalline nature of PLA [ 17 ]. The PXRD diffractogram of the microparticles showed no peaks.…”
Section: Resultsmentioning
confidence: 99%
“…To quantify the amount of drug in rabbit plasma, a validated HPLC validated [ 17 ] modified by Carceles-Rodriguez et al [ 3 ] was used. First, the samples were thawed.…”
Section: Methodsmentioning
confidence: 99%
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“…1.b) is a hydrophobic polymer belongs to the α-hydroxyl acid family. As a biodegradable and biocompatible, this polymer is widely used for many applications in pharmaceutical and medical areas because its decomposition products are not toxic and are easily excreted from human organism [12,13]. Several methods for the preparation of CDDs microparticles from PLA polymer were reported in the literature.…”
Section: Introductionmentioning
confidence: 99%
“…[14][15][16][17] A potential avenue for realizing sustained and safe pain relief is the use of biodegradable micro-and nanoparticles (NPs). [18][19][20][21][22][23][24] Commonly, controlled release is achieved by non-covalently encapsulating the therapeutic agent within the polymer matrix of biodegradable particles. 21,[25][26][27][28][29] As the particle degrades or is eroded the encapsulated drug is released.…”
Section: Introductionmentioning
confidence: 99%