Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Im, Seung Hyuk; Im, Dam Hyeok; Park, Su Jeong; Chung, Justin J.; Jung, Youngmee; Kim, Soo Hyun

doi:10.3390/molecules26102846

Cited by 40 publications

(24 citation statements)

References 108 publications

(125 reference statements)

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“…Due to the non-petroleum origin of LAc, LA, and PLA, and polymer’s ability to biodegradation [ 13 ], it is considered as a “double green” polymer. PLA and LA copolymers (e.g., block copolymers [ 14 ]) may be used for biomedical or pharmaceutical [ 15 , 16 , 17 , 18 ] applications. However, the main market of these polymers is packaging [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Grafted Lactic Acid Oligomers on Lignocellulosic Filler towards Biocomposites

et al. 2022

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Lactic acid oligomers (OLAs) were in situ synthesized from lactic acid (LAc) and grafted onto chokeberry pomace (CP) particleboards by direct condensation. Biocomposites of poly (lactic acid) (PLA) and modified/unmodified CP particles containing different size fractions were obtained using a mini-extruder. To confirm the results of the grafting process, the FTIR spectra of filler particles were obtained. Performing 1HNMR spectroscopy allowed us to determine the chemical structure of synthesized OLAs. The thermal degradation of modified CP and biocomposites were studied using TGA, and the thermal characteristics of biocomposites were investigated using DSC. In order to analyse the adhesion between filler particles and PLA in biocomposites, SEM images of brittle fracture surfaces were registered. The mechanical properties of biocomposites were studied using a tensile testing machine. FTIR and 1HNMR analysis confirmed the successful grafting process of OLAs. The modified filler particles exhibited a better connection with hydrophobic PLA matrix alongside improved mechanical properties than the biocomposites with unmodified filler particles. Moreover, a DSC analysis of the biocomposites with modified CP showed a reduction in glass temperature on average by 9 °C compared to neat PLA. It confirms the plasticizing effect of grafted and ungrafted OLAs. The results are promising, and can contribute to increasing the use of agri-food lignocellulosic residue in manufacturing biodegradable packaging.

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Section: Introductionmentioning

confidence: 99%

Grafted Lactic Acid Oligomers on Lignocellulosic Filler towards Biocomposites

et al. 2022

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“…The ACP-mediated directional differentiation of mesenchymal stem cells is affected by the concentration of free calcium ions; if the concentration decreases in the surrounding environment, osteogenic differentiation is reduced [ 58 ]. As a drug delivery carrier and scaffold material, PLLA has some problems, such as its weak stability of hydrophilic components and the burst release phenomenon, which need to be improved [ 59 ]. For the slow and long-term release of calcium ions, our ACP/PLLA scaffolds were coated with the PLGA membrane, which is biocompatible and has a sustained release capacity.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Mineralization Effects of an ASP/PLGA-ASP/ACP/PLLA-PLGA Composite Membrane as a Dental Pulp Capping Agent

Yan¹,

Yang

Liu³

et al. 2022

JFB

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Dental pulp is essential for the development and long-term preservation of teeth. Dental trauma and caries often lead to pulp inflammation. Vital pulp therapy using dental pulp-capping materials is an approach to preserving the vitality of injured dental pulp. Most pulp-capping materials used in clinics have good biocompatibility to promote mineralization, but their anti-inflammatory effect is weak. Therefore, the failure rate will increase when dental pulp inflammation is severe. The present study developed an amorphous calcium phosphate/poly (L-lactic acid)-poly (lactic-co-glycolic acid) membrane compounded with aspirin (hereafter known as ASP/PLGA-ASP/ACP/PLLA-PLGA). The composite membrane, used as a pulp-capping material, effectively achieved the rapid release of high concentrations of the anti-inflammatory drug aspirin during the early stages as well as the long-term release of low concentrations of aspirin and calcium/phosphorus ions during the later stages, which could repair inflamed dental pulp and promote mineralization. Meanwhile, the composite membrane promoted the proliferation of inflamed dental pulp stem cells, downregulated the expression of inflammatory markers, upregulated the expression of mineralization-related markers, and induced the formation of stronger reparative dentin in the rat pulpitis model. These findings indicate that this material may be suitable for use as a pulp-capping material in clinical applications.

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“…PLA materials range from amorphous to semi-crystalline polymers, possessing a glass transition temperature of 60 to 65 • C, a melting temperature of 130 to 180 • C, and a tensile modulus of 2.7 to 16 GPa [7]. PLA degrades inside the body within six months to two years and has been widely used as medical implants in the form of plates, screws, pins, and rods [11][12][13]. The gel permeation chromatography (GPC) analysis of the retrieved PLA bars, as shown in Table 2 suggests that the bars underwent degradation over time.…”

Section: Discussionmentioning

confidence: 99%

Novel Biodegradable 3D-Printed Analgesics-Eluting-Nanofibers Incorporated Nuss Bars for Therapy of Pectus Excavatum

Liu

Chen

Lee

et al. 2022

IJMS

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A novel hybrid biodegradable Nuss bar model was developed to surgically correct the pectus excavatum and reduce the associated pain during treatment. The scheme consisted of a three-dimensional (3D) printed biodegradable polylactide (PLA) Nuss bar as the surgical implant and electrospun polylactide–polyglycolide (PLGA) nanofibers loaded with lidocaine and ketorolac as the analgesic agents. The degradation rate and mechanical properties of the PLA Nuss bars were characterized after submersion in a buffered mixture for different time periods. In addition, the in vivo biocompatibility of the integrated PLA Nuss bars/analgesic-loaded PLGA nanofibers was assessed using a rabbit chest wall model. The outcomes of this work suggest that integration of PLA Nuss bar and PLGA/analgesic nanofibers could successfully enhance the results of pectus excavatum treatment in the animal model. The histological analysis also demonstrated good biocompatibility of the PLA Nuss bars with animal tissues. Eventually, the 3D printed biodegradable Nuss bars may have a potential role in pectus excavatum treatment in humans.

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Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Cited by 40 publications

References 108 publications

Grafted Lactic Acid Oligomers on Lignocellulosic Filler towards Biocomposites

Grafted Lactic Acid Oligomers on Lignocellulosic Filler towards Biocomposites

Anti-Inflammatory and Mineralization Effects of an ASP/PLGA-ASP/ACP/PLLA-PLGA Composite Membrane as a Dental Pulp Capping Agent

Novel Biodegradable 3D-Printed Analgesics-Eluting-Nanofibers Incorporated Nuss Bars for Therapy of Pectus Excavatum

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