Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression

Kim, Kyobum; Yeatts, Andrew B.; Dean, David; Fisher, John P.

doi:10.1089/ten.teb.2010.0171

Cited by 221 publications

(155 citation statements)

References 150 publications

(189 reference statements)

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“…Large pore sizes and scaffold porosities have been found to significantly enhance cell attachment, differentiation, proliferation and migration (Haugh et al 2009;Kim et al 2010;Murphy et al 2010;Murphy et al 2013). According to our study, a larger pore size (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…The primary function of porous biomaterial scaffolds in tissue engineering (TE) applications is to enable cells to attach, migrate and proliferate, thereby providing a suitable environment to support tissue growth (Hutmacher 2000;Kim et al 2010;Milan et al 2010). This is facilitated through the use of highly porous scaffold architectures, which enable nutrient and metabolite diffusion throughout, while also contributing to the shape and mechanical integrity of the tissue defect.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, researchers are required to employ analytical predictions, based on idealised flow through a cylinder or two plates (Blecha et al 2010;Goldstein et al 2001), or estimate wall shear stress (WSS) magnitudes from existing computational models (Bancroft et al 2002;Grayson et al 2008;Vance et al 2005;Yu et al 2004), see Table 1. However, fluid shear stresses are not only dictated by the exogenously applied loading regime (Kim et al 2010;Tai et al 2007;Widmer et al 1998), but also depend on the geometric features of a particular scaffold (i.e. architecture, pore size and porosity) and the precise contribution of each toward resulting mechanical stimulation within a scaffold is difficult to characterise due to the range of interacting parameters.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures

Zhao

Vaughan

McNamara

2015

Biomech Model Mechanobiol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures

Zhao

Vaughan

McNamara

2015

Biomech Model Mechanobiol

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“…Furthermore, little attention has been paid to patientspecific implant architecture and mechanical function or to designing viable strategies that would restore site-specific function [11]. Patient-specific implants could be achieved through the use of computer-aided design (CAD) [12,13]. However, procedure-planning and implant-CAD software rarely include modeling of implant mechanical properties or the anticipated in vivo biomechanical load.…”

Section: Current Challenges In Translating Bte Therapies To the Clinicmentioning

confidence: 99%

The Potential Impact of Bone Tissue Engineering in the Clinic

et al. 2016

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Bone tissue engineering (BTE) intends to restore structural support for movement and mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in traumatic, degenerative, cancer, or congenital malformation. While much effort has been put into BTE, very little of this research has been translated to the clinic. In this review, we discuss current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting. These approaches involve the primary components of tissue engineering: cells, growth factors and biomaterials discussed briefly in light of their clinical relevance. This review also presents upcoming advanced approaches for BTE applications and suggests a probable workpath for translation from the laboratory to the clinic.

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“…These include drug delivery systems (Svirskis et al, 2010), metallic implants (Ryan et al, 2006), prosthetic vascular grafts (Roll et al, 2008), bone and cartilage substitutes (Busenlechner et al, 2008;Berghaus et al, 2010), synthetic surgical meshes (Shankaran et al, 2011) and scaffolds for the engineering of artifi cial tissues (Kim et al, 2010). However, a riskless and successful use of such devices in clinical practice is only possible, if they exhibit an adequate biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

The dorsal skinfold chamber: window into the dynamic interaction of biomaterials with their surrounding host tissue

Laschke

Vollmar²,

Menger³

2011

eCM

146

128

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The implantation of biomaterials into the human body has become an indispensable part of almost all fi elds of modern medicine. Accordingly, there is an increasing need for appropriate approaches, which can be used to evaluate the suitability of different biomaterials for distinct clinical indications. The dorsal skinfold chamber is a sophisticated experimental model, which has been proven to be extremely valuable for the systematic in vivo analysis of the dynamic interaction of small biomaterial implants with the surrounding host tissue in rats, hamsters and mice. By means of intravital fl uorescence microscopy, this chronic model allows for repeated analyses of various cellular, molecular and microvascular mechanisms, which are involved in the early infl ammatory and angiogenic host tissue response to biomaterials during the initial 2-3 weeks after implantation. Therefore, the dorsal skinfold chamber has been broadly used during the last two decades to assess the in vivo performance of prosthetic vascular grafts, metallic implants, surgical meshes, bone substitutes, scaffolds for tissue engineering, as well as for locally or systemically applied drug delivery systems. These studies have contributed to identify basic material properties determining the biocompatibility of the implants and vascular ingrowth into their surface or internal structures. Thus, the dorsal skinfold chamber model does not only provide deep insights into the complex interactions of biomaterials with the surrounding soft tissues of the host but also represents an important tool for the future development of novel biomaterials aiming at an optimisation of their biofunctionality in clinical practice.

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Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression

Cited by 221 publications

References 150 publications

Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures

Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures

The Potential Impact of Bone Tissue Engineering in the Clinic

The dorsal skinfold chamber: window into the dynamic interaction of biomaterials with their surrounding host tissue

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