Stereological evaluation of volumetric asymmetry in healthy human cerebellum

Göçmen-Mas, Nüket; Pelin, Can; Canan, Sinan; Yazıcı, Ayşe Canan; Zağyapan, Ragıba; Senan, Sevda; Karabekir, Hamit Selim; Şahin, Bünyamin

doi:10.1007/s00276-008-0424-4

Cited by 24 publications

(35 citation statements)

References 25 publications

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“…Asymmetrical and volumetric changes in intracranial structures are of importance for both clinicians and anatomists [12,25].…”

Section: Discussionmentioning

confidence: 99%

“…Many authors claimed that the automatic method is fast, efficient, unbiased, and safe. But others noted the traced measurement method as the "gold standard" against the automatic method [10,12].…”

Section: Discussionmentioning

confidence: 99%

“…In contract to the previous studies, we used the stereological measurement technique, which was firstly used in the evaluation of cerebellar asymmetry by Gocmen-Mas et al [12]. The stereological method is simple, cheap, reliable, and unbiased.…”

Section: Discussionmentioning

confidence: 99%

“…Points hitting the middle ears were manually counted for volume esti-mation, bilaterally. The volumes were also estimated using the Cavalier's principle of stereological methods as described in previous studies [1,10,12,15] by utilising the formula given below:…”

Section: Morphometric and Stereological Analysesmentioning

confidence: 99%

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Investigation of temporal bone asymmetry in cases with unilateral tinnitus: morphometric and multicentric clinical study

et al. 2013

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“…Asymmetrical and volumetric changes in intracranial structures are of importance for both clinicians and anatomists [12,25].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Morphometric and Stereological Analysesmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of temporal bone asymmetry in cases with unilateral tinnitus: morphometric and multicentric clinical study

et al. 2013

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“…alcohol use and cerebellar volume of healthy individuals have all been studied previously (Hutchinson et al;Keller et al, 2003;Laycock et al, 2008;Hill et al, 2007;Göçmen-Mas et al, 2009). In blind individuals, visual cortex and plasticity have also been studied profusely (Burton, 2003;Lambert et al, 2004).…”

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confidence: 99%

Comparison of Cerebellar Volume Between Subjects with Bilateral Congenital Blindness and Healthy Individuals

2013

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SUMMARY: Cerebellum regulates motor control and physical coordination. It is known that when eye and hand need to be worked in combination, cerebellum is active and it provides coordination between eye and hand. Cerebellar cortex atrophy appears with dismetry and saccadic eye movement. If there is no stimulant related to vision, how cerebellum is adopted under this circumstance? In order to explore this, 27 male and 16 female volunteers with bilateral congenital blindness were compared with 35 male and 33 female healthy volunteers in this study. MR images of cross-sectional sequential cerebellum of volunteers with 1.5 mm thickness were realized in coronal plane. The surface area of apparent cerebellum seen in cross-sections was calculated by using Onis (Ver. 2.1) programme. Surface area data obtained by systematic randomized sampling were converted to volume by Cavalieri method. Cerebellar volume of bilateral congenital blind male was 128.15 ± 11.11 cm 3 , and cerebellar volume of bilateral congenital blind female was 118.60 ±10.73 cm 3. Cerebellar volume for healthy men and women were 132.89 ± 12.51 cm 3 and 125.97 ± 10.78 cm 3 , respectively. It was revealed that cerebellar volume for bilateral congenital blind men was smaller than that of healthy men, but this difference was not significant. On the other hand cerebellar volume of bilateral congenital blind women was significantly smaller than that of healthy women (p<0.05). No asymmetry was detected between right and left side of cerebellum in both bilateral congenital blind and healthy subjects. 240alcohol use and cerebellar volume of healthy individuals have all been studied previously (Hutchinson et al.;Keller et al., 2003;Laycock et al., 2008;Hill et al., 2007;Göçmen-Mas et al., 2009). In blind individuals, visual cortex and plasticity have also been studied profusely (Burton, 2003;Lambert et al., 2004). However, cerebellar volume has not been a subject of research in people with bilateralcongenital blindness. How does the cerebellum adapt itself to the absence of visual stimulants? Our study will shed light on this issue. MATERIAL AND METHODIncluded in the study were 27 males (average age 39±12) and 16 females (average age 32±10) with bilateral congenital blindness. In order to make a comparison with healthy individuals, 35 males (average age 43±14) and 33 females (average age 37±9) were also included in the study. Following an approval from the ethics committee of Abant Izzet Baysal University Faculty of Medicine, consecutive images were obtained in coronal direction with 1.5 mm section thickness from the volunteers by using the 1.5 Tesla Magneton Symphony model MR device made in Germany, at the Department of Radiology in our hospital (Levitt et al., 1999). Images were saved in Dicom format. Images were then viewed by using the Onis (Ver. 2.1) software. All the sections showing cerebellum from anterior towards posterior were observed. Following a windowing procedure that would distinguish cerebellum from peripheral tissues, the same software was used t...

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Laterality of cerebellar afferent and efferent pathways in a healthy right‐handed population: A diffusion tensor imaging study

Kim

et al. 2018

J of Neuroscience Research

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The cerebellum communicates with the cerebral cortex through the cortico‐ponto‐cerebellar tract (CPCT, cerebellar afferent) and the dentato‐rubro‐thalamo‐cortical tract (DRTCT, cerebellar efferent). This study explored the laterality of CPCT and DRTCT in a right‐handed population. Forty healthy right‐handed subjects (18 males and 22 females with age range of 26–79 years old) who underwent diffusion tensor imaging (DTI) were retrospectively enrolled. Bilateral CPCT, DRTCT, and the corticospinal tract (CST) were reconstructed using probabilistic diffusion tensor tractography (DTT). Tract volume (TV) and fractional anisotropy (FA) were compared between dominant and non‐dominant tracts. Subjects were divided into age groups (20–40, 41–60, and 61–80 years), and the DTI‐derived parameters of the groups were compared to determine age‐related differences. TV and FA of non‐dominant CPCT were higher than those of dominant CPCT, and the dominant CST was higher than the non‐dominant CST. The TV and FA of DRTCT showed no side‐to‐side difference. The 61–80 years age group had the highest TV of the dominant and non‐dominant DRTCT among the three groups and the highest FA of the non‐dominant CPCT and DRTCT. The results revealed the structural characteristics of CPCT and DRTCT using probabilistic DTT. Normal asymmetric patterns and age‐related changes in cerebellar white matter tracts may be important to researchers investigating cerebro‐cerebellar structural connectivity.

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Stereological evaluation of volumetric asymmetry in healthy human cerebellum

Abstract: There was no cerebellar asymmetry between compared groups. The stereological evaluation of cerebellar asymmetry in humans correlate with both gender and age groups is of importance for both clinicians and anatomists. The technique is simple, reliable, unbiased and inexpensive.

Cited by 24 publications

References 25 publications

Investigation of temporal bone asymmetry in cases with unilateral tinnitus: morphometric and multicentric clinical study

Investigation of temporal bone asymmetry in cases with unilateral tinnitus: morphometric and multicentric clinical study

Comparison of Cerebellar Volume Between Subjects with Bilateral Congenital Blindness and Healthy Individuals

Laterality of cerebellar afferent and efferent pathways in a healthy right‐handed population: A diffusion tensor imaging study

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