Numerical simulations of the gas-seeding strategies required for planar laser-induced fluorescence in a Mach 10 (approximately Mach 8.2 postshock) airflow were performed. The work was performed to understand and quantify the adverse effects associated with gas seeding and to assess various types of seed gas that could potentially be used in future experiments. In prior experiments, NO and NO2 were injected through a slot near the leading edge of a flatplate wedge model used in NASA Langley Research Center's 31 in. Mach 10 air tunnel facility. In this paper, nitric oxide, krypton, and iodine gases were simulated at various injection rates. Simulations showing the deflection of the velocity boundary layer for each of the cases are presented. Streamwise distributions of velocity and concentration boundary-layer thicknesses, as well as vertical distributions of velocity, temperature, and mass distributions, are presented for each of the cases. A comparison between simulated streamwise velocity profiles and experimentally obtained molecular tagging velocimetry profiles using a nitric oxide seeding strategy is performed to verify the influence of such a strategy on the boundary layer. The relative merits of the different seeding strategies are discussed. The results from a custom solver based on OpenFOAM version 2.2.1 are compared against results obtained from ANSYS® Fluent version 6.3. Nomenclature c p = specific heat at constant pressure, kJ∕kg∕K D i;j = binary diffusion coefficient, m 2 ∕s D i;m = diffusion coefficient of species i into the mixture, m 2 ∕s h i = sensible enthalpy of species i, kJ∕kg h s = sensible enthalpy, kJ∕kg I = identity matrix J i = diffusion flux of species i, kg∕m 2 ∕s Kn = Knudsen number k = thermal conductivity, W∕m∕K Ma = Mach number M i = molar mass of species i, kg∕kmol P = pressure, Pa P inf = freestream pressure, Pa P stag = stagnation pressure, Pa P w = wall pressure, Pa R = ideal gas constant, J∕K∕mol Re = Reynolds number R i = mass source of species i S h = enthalpy source, kJ∕s∕m 3 T = temperature, K T stag = stagnation temperature, K t = time, s U = velocity, m∕s U e = boundary-layer edge velocity, m∕s W z = wedge width, mm w c = species mass fraction of interest x = distance from leading edge, m x slot = length of seed slot, mm Y i = mass fraction of species i α = thermal conductivity divided by specific heat at constant pressure, kg∕m∕s β = oblique shock angle δ = boundary-layer thickness, m δ c = concentration boundary-layer thickness, m θ plate = plate angle of attack μ = viscosity, kg∕m∕s ρ = density, kg∕m 3 σ i;j = average species collision diameter, m τ = viscous stress tensor, Pa Ω d = diffusion collision integral Ω v = viscous collision integral