Stereoselective binding of zopiclone to human plasma proteins

Stability tests of zopiclone in whole blood

“…Both albumin and a-1-acid glycoprotein are involved in zopiclone protein binding [40]. Protein binding might protect drugs from in vitro breakdown, but no relationship between concentration decrease during storage and drug binding has been confirmed [37].…”

Zopiclone degradation in biological samples : Characteristics and consequences in forensic toxicology

“…Plasma protein binding of ZOP was reported as 45% in one study [93] and 80% in another [94]. Both albumin and α-1-acid glycoprotein contribute to protein binding but also other plasma proteins might be involved (e.g.…”

“…S(+)-ZOP showed higher binding to α-1-acid glycoprotein and albumin than R(−)-ZOP. However, a higher total protein binding was observed for R(−)-ZOP and an explanation for this was that R(−)-ZOP also binds to other proteins [94]. The distribution of ZOP into body tissues including the brain is rapid and widespread, and ZOP is excreted in urine, saliva and breast milk.…”

“…Both albumin and α-1-acid glycoprotein are involved in ZOP protein binding [94]. Protein binding might protect drugs from in vitro breakdown, although no relationship between concentration decrease in connection during storage and plasma protein binding has been confirmed [29].…”

Influence of pre-analytical conditions on the interpretation of zopiclone concentrations in whole blood

“…The plasma protein binding has been reported to 45% [15] and to 80% [16] in which albumin and a-1-acid glycoprotein participate. The presence of other drugs and the plasma protein concentration itself may affect the ability to bind zopiclone.…”