Stereotactic body radiotherapy for small hepatocellular carcinoma: A retrospective outcome analysis in 185 patients

Sanuki, Naoko; Takeda, Atsuya; Oku, Yohei; Mizuno, Takahisa; Aoki, Yosuke; Eriguchi, Takahisa; Iwabuchi, Shogo; Kunieda, Etsuo

doi:10.3109/0284186x.2013.820342

Cited by 228 publications

(211 citation statements)

References 21 publications

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“…SBRT delivers a highly conformal, potent dose of radiation to the tumor in some fractions, while minimizing radiation damage to organs at risk. SBRT provides excellent local control for HCC with a reported control rate of 80-90% (2)(3)(4).…”

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confidence: 99%

Dose–function Histogram Evaluation Using 99mTc-GSA SPECT/CT Images for Stereotactic Body Radiation Therapy Planning for Hepatocellular Carcinoma Patients: A Dosimetric Parameter Comparison

Toya

Saitô

Shiraishi

et al. 2018

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Abstract. Background/Aim: We evaluated the influence of previous treatments on the parametric discrepancies between dose-volume histograms (DVHs) and dose-function histograms (DFHs) generated based on 99m Tc-GSA SPECT images of hepatocellular carcinoma (HCC) patients treated with stereotactic body radiation therapy (SBRTPrimary liver cancer is the third most common cause of cancer death worldwide. Hepatocellular carcinoma (HCC) accounts for 85%-90% of primary liver cancers (1). Stereotactic body radiation therapy (SBRT) for HCC has been introduced as an alternative to standard treatments such as surgical resection and radiofrequency ablation (RFA) (1). SBRT delivers a highly conformal, potent dose of radiation to the tumor in some fractions, while minimizing radiation damage to organs at risk. SBRT provides excellent local control for HCC with a reported control rate of 80-90% (2-4).HCC response to radiation therapy (RT) exhibits a doseresponse relationship (5), but a fine balance is required between delivering a sufficient RT dose to control the HCC and avoiding radiation-induced liver toxicity. Radiationinduced liver injury (RILD), which occurs in 10-20% of HCC patients undergoing SBRT, remains a problematic adverse effect, because of pre-existing liver dysfunctions occurring secondary to comorbid conditions such as hepatitis B/C infection and cirrhosis (3, 4). The percentage of normal liver volume receiving a dose over the threshold dose calculated based on a dose-volume histogram (DVH) is commonly used for determining dose constraints and predicting radiation-induced liver toxicity; however, it has limited predictive ability (6, 7).A drawback of using DVH for SBRT planning in HCC is the lack of functional information because DVHs are generated based on computed tomography (CT) images, which provide only morphological information. A dosefunction histogram (DFH) generated based on single photon emission computed tomography (SPECT) images may facilitate the assessment of the functional status of organs at risk. For treatment planning in lung cancers, Marks et al. (8) performed DFH calculation using 99m Tc-labeled macroaggregated albumin and observed decreases in lung perfusion at, adjacent to, and separate from tumor in 94%, 74%, and 42% of patients, respectively. 99m Tc-labeled diethylene triamine pentaacetate-galactosyl human serum albumin 1511

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confidence: 99%

Dose–function Histogram Evaluation Using 99mTc-GSA SPECT/CT Images for Stereotactic Body Radiation Therapy Planning for Hepatocellular Carcinoma Patients: A Dosimetric Parameter Comparison

Toya

Saitô

Shiraishi

et al. 2018

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“…For obvious reasons, articles published during the first of those two years, in this case 2013, will have a higher chance to be among those most cited. Although not among the top five mentioned above, several other articles published during 2014 have also contributed substantially to the impact factor for 2015, and will do so also for the coming year 2016 [7][8][9][10][11][12]. As has been the case during several years [13], articles within radiotherapy and radiophysics are among the most cited, but for 2015, not as dominating as before reflecting the profile of Acta Oncologica as a general oncology journal.…”

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confidence: 94%

Tell all the good news as soon as possible

Glimelius

2016

Acta Oncologica

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“…Sanuki et al 28 reported a 3-year OS of 70% and grade 3 RILD of 13% using a dose of either 5 × 8 Gy for CP-A or 5 × 7 Gy for CP-B. Using a 6 × 4-9 Gy regimen, Bujold et al 25 reported a 1-year OS of 48%.…”

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confidence: 99%

Stereotactic body radiation therapy in hepatocellular carcinoma: Optimal treatment strategies based on liver segmentation and functional hepatic reserve

Wang

Chung

Hsu

et al. 2015

Reports of Practical Oncology & Radiotherapy

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Stereotactic body radiotherapy for small hepatocellular carcinoma: A retrospective outcome analysis in 185 patients

Cited by 228 publications

References 21 publications

Dose–function Histogram Evaluation Using 99mTc-GSA SPECT/CT Images for Stereotactic Body Radiation Therapy Planning for Hepatocellular Carcinoma Patients: A Dosimetric Parameter Comparison

Dose–function Histogram Evaluation Using 99mTc-GSA SPECT/CT Images for Stereotactic Body Radiation Therapy Planning for Hepatocellular Carcinoma Patients: A Dosimetric Parameter Comparison

Tell all the good news as soon as possible

Stereotactic body radiation therapy in hepatocellular carcinoma: Optimal treatment strategies based on liver segmentation and functional hepatic reserve

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