Stereotactic linear accelerater‐based radiosurgery for the treatment of patients with glomus jugulare tumors

Abstract

Activated layered double hydroxides (LDHs) with high crystallinity, obtained by calcination/rehydration of LDH precursors synthesized by urea decomposition, have higher catalytic activity in acetone self‐condensation and Knoevenagel reactions than less crystalline materials obtained from LDH precursors synthesized by titration co‐precipitation. The activated LDHs possess both basic and acidic sites. High resolution transmission electron microscopy (HRTEM) confirms that the highly crystalline activated LDHs retain the lattice structure of the LDH precursors with lattice parameters a = b = 0.31 ± 0.01 nm and α = 60 ± 2°. An acid‐base catalytic mechanism has been proposed to interpret the catalytic behavior based on the fact that acid‐base hydroxyl group pairs on the activated LDH surface have a separation of 0.31 nm. It is proposed that the active sites are mainly located on the ordered array of hydroxyl sites on the basal surfaces rather than on the edges, as has been previously suggested. © 2007 American Institute of Chemical Engineers AIChE J, 2007

Efficacy and safety of stereotactic radiosurgery for glomus jugulare tumors

“…4 With the advent of improved microsurgical techniques and the use of combined approaches, the mortality rate has lowered substantially; however, cranial nerve injury continues to be a problem. [18][19][20][21] In a retrospective series of 176 patients treated between 1972 and 1998 and reported by Jackson, et al, 12 in 85% complete surgical control was described. The remaining 15% of their patients had a subtotal resection or recurrence.…”

“…Nevertheless, their patient numbers were small. In a more recent series by Maarouf, et al, 19 the authors reported their experience with LINAC therapy in 12 patients with glomus jugulare tumors. In their study the median dose was 15 Gy and the median follow-up period was 4 years.…”

Skull Base Tumors

“…[ 83 ]. Should re-operation not be possible, high-dose particle beam therapy or IMRT should be recommended Embolization alone does not prevent further tumor progression [ 92 ]. Surgical resection is the only treatment option that can offer immediate and complete tumor elimination.…”

Radiosurgery for glomus jugulare: history and recent progress

“…Poznanovic et al 36 published a series report in which 8 patients received LINAC treatment for glomus jugulare, and all patients exhibited tumor control and clinical stability over an average follow-up time of 15.6 months. Maarouf et al 25 followed 12 patients who received LINAC treatment for glomus jugulare for a median duration of 48 months. Although no tumors increased in size (80% regressed and 20% remained unchanged), 8 improved clinically and 4 worsened.…”