Stereotactic Radiosurgery (SRS) with Volumetric Modulated Arc Therapy (VMAT): Interim Results of a Multi-arm Phase I Trial (DESTROY-2)

The role of radiotherapy in bone metastases: A critical review of current literature

“…Eight prospective studies identified which evaluate the efficacy and safety of SBRT for bone metastases (spinal or non‐spinal; Ahmed et al., ; Chang et al., ; Deodato et al., ; Garg et al., ; Nguyen et al., ; Owen et al., ; Ryu et al., ; Wang et al., ; Table ). The majority of studies referred to SBRT for spinal bone metastases (Ahmed et al., ; Chang et al., ; Garg et al., ; Nguyen et al., ; Ryu et al., ; Wang et al., ).…”

“…The majority of studies referred to SBRT for spinal bone metastases (Ahmed et al., ; Chang et al., ; Garg et al., ; Nguyen et al., ; Ryu et al., ; Wang et al., ). Seven of the eight trials recorded tumour control rates over 80% for the first year (Ahmed et al., ; Chang et al., ; Deodato et al., ; Garg et al., ; Nguyen et al., ; Owen et al., ; Wang et al., ). Pain relief was issued in three of the eight trials (Nguyen et al., ; Owen et al., ; Wang et al., ).…”

“…All studies recorded toxicity events (Ahmed et al., ; Chang et al., ; Deodato et al., ; Garg et al., ; Nguyen et al., ; Owen et al., ; Ryu et al., ; Wang et al., ). Acute toxicity was recorded in three of the eight studies and which was only grade 1 and 2 (Chang et al., ; Deodato et al., ; Owen et al., ). Neurologic toxicity grade 3 and 4 reported only one study which was apply single fraction schedule of SBRT (Garg et al., ).…”

“…During the last decades, SBRT was utilised as a potential primary treatment for oligometastastic disease and for re‐irradiation of bone metastases (Sahgal et al., ). There is a limited number of prospective studies using SBRT for bone metastases, all showing that SBRT provides excellent tumour control and sufficient pain response with low toxicity rates even in radioresistant tumours (Ahmed et al., ; Chang et al., ; Deodato et al., ; Garg et al., ; Nguyen et al., ; Owen et al., ; Ryu et al., ; Wang et al., ). The results of our review are in accordance with two recently published overview articles which are dealing with SBRT for bone metastases (Bedard et al., ; Bhattacharya & Hoskin, ).…”

Volumetric Modulated Arc Therapy (VMAT) make a difference in retro-orbital irradiation treatment of patients with bilateral Graves’ ophthalmopathy. Comparative analysis of dosimetric parameters from different radiation techniques

“…[10][11][12] Recently, VMAT has attracted increasing attention because of its greatly improved delivery efficiency over fixed-field IMRT, 13,14 especially in those tumors which require high precision in dose administration as is the case in radiosurgery. [15][16][17] However, so far there has been no studies focusing on the use of VMAT for treatment of Graves' ophthalmopathy and there is only one study with IMRT used for this disease. 18 In the present dosimetric study, we were able to demonstrate that VMAT offered a better and more conformal coverage of the PTV compared to 3DCRT and LOF and, thus, resulted in a better CI.…”