Steric stabilisation of self-assembled cubic lyotropic liquid crystalline nanoparticles: high throughput evaluation of triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

“…Chong et al reported the use of Pluronics ® with lower molecular weights than Pluronic ® F127 (i.e., Pluronic ® F87, F68, P123, P105, P104, P84) as steric stabilizers (Fig. 6) [160]. Pluronics ® with PEG chains greater or equal to 37 PEG units were reported to stabilize phytantriol cubosome dispersions, which had Pn3m space group symmetry.…”

Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

“…To date, the most widely used surfactant for the stabilization of LCN is P407 which is composed of polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO) block copolymer (26). The hydrophobic portion (PPO) is responsible for the anchoring to lipid bilayer, and hydrophilic portion (PEO) is oriented toward the aqueous medium.…”

“…The stabilizing effect of RH and EL might be attributed to the balance between hydrophilic and hydrophobic moieties. Hydrophilic moiety of both RH and EL is composed of PEO which acts as a steric barrier to prevent aggregation of nanoparticles, and hydrophobic moiety is composed of stearate for RH and ricinoleate for EL, respectively, which have different affinity property to bind with lipid bilayer (26). Among the concentrations of RH and EL tested, RH formed stable dispersion as low as 0.5% w/w concentration while EL failed to stabilize the dispersion at lower than 1.5% w/w concentration (Table I).…”

Self-healing coatings

“…Organic templating techniques, using metal alkoxides, have also been used for making carriers or encapsulation systems in self-healing coatings applications [187][188][189]. The stability of the templating structures is sensitive to processing conditions and chemistry and, therefore, they are not suitable for all applications.…”