Sterile Pyuria in Patients Admitted to the Hospital With Infections Outside of the Urinary Tract

Abstract

Objectives: The objective of this study was to determine the incidence, associations, evaluation, and management of pyuria in patients admitted to the hospital with nonurinary infections.Methods: This study abstracted inpatient records of consecutive patients hospitalized for pneumonia, intra-abdominal infections, female genital tract infections (GYN infections), bacterial septicemia, and enteritis in the pediatric and adult medical and surgical units at an academic medical center.Results: The study population included 210 patients (66 children; 144 adults). Nearly one-third had >5 white blood cells (WBCs) per high-power field (pyuria). Pyuria was more common in women (P < .001) and in patients with GYN infections (P ‫؍‬ .001) and less common in patients with pneumonia (P < .

Preoperative pyuria predicts advanced pathologic tumor stage and worse survival in patients with urothelial carcinoma of the upper urinary tract treated by radical nephroureterectomy

“…This phenomenon might indicate us that metabolic comorbidity (especially kidney involvement) could attribute to the presence of pyuria. However, little published evidence was found to support this hypothesis of the potential association between pyuria and metabolic comorbidity [12,29], and we also failed to evaluate the severity of metabolic comorbidity for lacking of the corresponding medical data. Thirdly, it would provide greater predictive value if pyuria were combined with other inflammatory biomarkers.…”

Effect of Preoperative Bacteriuria and Pyuria on Intravesical Recurrence in Patients with Upper Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy

“…Preoperative bacteriuria was defined as ≥5 bacteria/high-power field (HPF) in centrifuged urine sediment (16). Preoperative pyuria was defined as >5 white blood cells/HPF in centrifuged urine sediment (17).…”

Sterile Pyuria

“…2 Specific populations have a higher risk of this condition; for example, the frequency of detection of sterile pyuria was 23% among inpatients in one study (excluding those with urinary tract infection), and sterile pyuria is more common among women than among men because of pelvic infection. 3 Subsequent to initial detection, the costs of laboratory, radiographic, and invasive evaluation in such large populations can have a considerable effect on health care expenditures. 4 Although colony counts greater than 100,000 colony-forming units (CFU) per milliliter in voided urine have historically been used to distinguish bacterial urinary tract infection from colonization, 5 many U.S. laboratories currently report bacterial colony counts of more than 1000 CFU per milliliter in urine as being diagnostic of bacteriuria.…”