Sterility and Testicular Atrophy Related to Cyclophosphamide Therapy

Fairley, Kenneth F.; Barrie, JeanU.; Johnson, Warren

doi:10.1016/s0140-6736(72)90358-3

Cited by 336 publications

(69 citation statements)

References 10 publications

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“…The mechanism for this gradually increasing tendency toward toxicity is not known. It may be speculated that the granulocyte proliferative precursor pool is gradually reduced in a manner similar to the reduction of the erythroid precursor population of the marrow of animals receiving chronic low-dose irradiation (20) and analogous to the sterilizing effects of cyclophosphamide on the testis or ovary (21,22). That this response has not been seen before may perhaps be attributable to a protective effect of concommitent corticosteroids in other studies.…”

Section: Discussionmentioning

confidence: 91%

The effect of cyclophosphamide on leukocyte kinetics and susceptibility to infection in patients with wegener's granulomatosis

Dale

Fauci

Wolff

1973

Arthritis & Rheumatism

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In eight patients with Wegener's granulomatosis effective cyclophosphamide therapy significantly reduced blood neutrophil, monocyte, and lymphocyte counts; lymphocyte counts were most severely reduced. The turnover rate for DF32P-labeled neutrophils were decreased from elevated to normal levels with treatment. Cutaneous inflammatory responses were normal before and during therapy. In five patients, cyclophosphamide eventually had to be discontinued because of progressive severe leukopenia. Infectious complications of therapy have not been observed.

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Section: Discussionmentioning

confidence: 91%

The effect of cyclophosphamide on leukocyte kinetics and susceptibility to infection in patients with wegener's granulomatosis

Dale

Fauci

Wolff

1973

Arthritis & Rheumatism

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“…In man, alkylating agents have been shown to cause infertility in doses which are unaccompanied by significant systemic toxicity. Thus, a daily dose of only 1 to 2 mg/kg of Cp caused azoospermia in all of 31 men who received this treatment (Fairley et al, 1972). Testicular histology in such patients reveals marked atrophic changes, with most tubules consisting chiefly of Sertoli cells (Sherins & de Vita, 1973).…”

Section: Discussionmentioning

confidence: 98%

“…Many alkylating agents have been found to produce infertility, both in man and in animals (Jackson, Fox & Craig, 1959;Miller, 1971;Fairley, Barrie & Johnson, 1972 Medical Director, Lilly Industries Pty. Ltd., Sydney, Australia) and studies with rats have been chiefly concerned with morphological changes in testicular tissue, without in vivo assessment of fertility (Welter, 1963;Bustos-Obregon & Feito, 1974 …”

Section: Introduction Methodsmentioning

confidence: 99%

A Comparison of the Antifertility Effects of Alkylating Agents and Vinca Alkaloids in Male Rats

Cooke

Nikles

Roeser

1978

British J Pharmacology

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The anti‐fertility effects of cyclophosphamide, nitrogen mustard, vincristine and vinblastine were studied and compared in male rats. The effects of the drugs on body weight and haematological values were used to monitor the pharmacological actions of the drugs. All four drugs impaired fertility, the severity of the impairment depending on dose and duration of treatment. Testicular size and histological appearances remained mostly normal, even in infertile animals, but seminiferous tubules were fewer in number and maturation arrest at the spermatid level was evident in some sections. Recovery of drug‐induced infertility occurred in 64% of treated animals, 9 to 40 weeks after cessation of treatment. Morbidity and mortality were much higher with alkylating agents than with vinca alkaloids for approximately similar degrees of impairment in fertility.

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“…Because cyclophosphamide may be a potent immunosuppressive agent, and has the risk of mutagenicity and sterility in younger patients (IARC Working Group, 1980;Fairley et al, 1972), we tried to avoid its use. We discontinued treatment based on the results of gene analysis.…”

Section: Figmentioning

confidence: 99%

Cyclophosphamide therapy for pure red cell aplasia associated with granular lymphocyte‐proliferative disorders

1997

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Granular lymphocytes have been characterized as cells with azurophilic granules in the cytoplasm. Patients with increased numbers of granular lymphocytes are designated as granular lymphocyte‐proliferative disorders (GLPDs). A variety of haematological abnormalities are associated with T‐cell‐lineage GLPD. Among these, pure red cell aplasia is frequent, and adequate therapy is required. Seven patients with pure red cell aplasia, or a related condition complicating T‐cell‐lineage GLPD, were entered into this study. Cyclophosphamide was initiated at a daily oral dose of 100 mg. After 2 weeks the dose was reduced to 50 mg/d, and maintained at that dose. Cyclophosphamide was administered until the lymphocyte count was <1 ×109 l and T‐cell receptor‐β gene analysis was used to monitor the response to treatment. All the patients were successfully treated, irrespective of their former treatment. Clinical remission was associated with the disappearance of the abnormal granular lymphocyte clone, as detected by Southern blot hybridization analysis. Therapeutic responses began after 8 weeks, and clinical complete remissions were obtained after 6 months. Oral cyclophosphamide monotherapy can successfully treat the pure red cell aplasia associated with T‐cell‐lineage GLPD.

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Sterility and Testicular Atrophy Related to Cyclophosphamide Therapy

Cited by 336 publications

References 10 publications

The effect of cyclophosphamide on leukocyte kinetics and susceptibility to infection in patients with wegener's granulomatosis

The effect of cyclophosphamide on leukocyte kinetics and susceptibility to infection in patients with wegener's granulomatosis

A Comparison of the Antifertility Effects of Alkylating Agents and Vinca Alkaloids in Male Rats

Cyclophosphamide therapy for pure red cell aplasia associated with granular lymphocyte‐proliferative disorders

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