Steroid and lipid metabolism.1 The hypocholesteremic effect of estrogen metabolites

Antiestrogenic activities of Ginkgo biloba extracts

“…These mechanisms include the activities of the enzymes participating in the biosynthesis or catabolism of estradiol, such as CYP19 (aromatase; an enzyme converting testosterone to estrogens), or CYP1A (group of enzymes involved in estradiol catabolism) [44]. Some reports have shown that the CYP1A-dependent EROD activity induced by AhR agonists can stimulate the metabolism of E 2 to a weak estrogen, 2-hydroxyestrone (2-OHE1) [33,[45][46][47][48][49][50], and inhibit the aromatase activity [32]. In addition, it has been suggested that the antiestrogenic activity of AhR agonists may be complex and related to cross-talk between the AhR and ER signaling pathways [51][52][53][54].…”

Effects of Undernutrition on Reproductive Function in the Human*

“…Decreased peripheral conversion of androstenedione to estrone may be implicated as this conversion is thought to occur to some extent in fat cells (126,127). One important observation, in fact, shows that with weight loss the metabolism of estradiol which normally proceeds with 16 hydroxylation, is decreased in favor of 2 hydroxylation and the eventual formation of the catechol estrogen 2-methoxy estrone which has no intrinsic activity (128,129) and may in fact act as an anti-estrogen as it will bind to some estrogen receptors (130). This compound also possesses the structure of a catechol estrogen in that it has the potential for interacting both with catecholamine and estrogen mediated systems in the central nervous system.…”

Inhibition of Cholesterol Biosynthesis in the Rat by 3 -(2-diethylaminoethoxy)androst-5-en-17-one, hydrochloride

“…Several synthetic agents have been shown to inhibit cholesterol biosynthesis and cause accumulation of desmosterol ( 1,2,3). The latter phenomenon has been correlated with inhibitory effect of the compound on reduction of desmosterol to cholesterol (4) and lanosterol to dihydrolanosterol (5).…”