Steroid glucosides from vernonia amygdalina, a possible chimpanzee medicinal plant

Jisaka, Mitsuo; Ohigashi, Hajime; Takegawa, Kazunori; Hirota, Mitsuru; Irie, Ryozo; Huffman, Michael A.; Koshimįzu, Koichi

doi:10.1016/0031-9422(93)80019-o

Cited by 92 publications

(57 citation statements)

References 5 publications

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“…The report indicated that lower dose (100 mg/kg) of Vernonia amygdalina leaves extracts had no deleterious effect on the testis. This result is in conformity with several reports (Ohigashi et al, 1991;Jisaka et al;Igile et al;Oyeyemi et al).…”

Section: Discussionsupporting

confidence: 83%

The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity

2013

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SUMMARY:Vernonia amygdalina (bitter-leaf) is native to West Africa but occurs mostly in its cultivated form in various parts of central and southern Nigeria. It is a dark-green leafy vegetable commonly used in cooking and as folkloric medicine for the management of several diseases in Nigeria. In the present study, the effects of varying doses of ethanolic leaf extract of Vernonia amygdalina on the rat testis histo-morphometry were investigated. Forty male wistar rats were divided into groups of four. Group A, as the control was given 10 ml/kg/day/oral distilled water while Group B, C and D subsequently treated with 100, 300 and 600 mg/kg/day/oral route Vernonia amygdalina leaves extract respectively for 56 days. Results showed that Group B rats had normal testis histology comparable to the control group. However, rats in Group C and D exhibited dose-dependent poor testes histo-morphometric profiles, with the higher dosage-group (D) providing a worse feature. Thus, there was a statistically significant (p < 0.05) reduction in the tubular diameter, crosssectional area of the tubules, number of tubular profiles per unit area and the mean numerical density of seminiferous tubules of Group C and Group D animals compared to the control group. Our results therefore indicated that, while the lower dose (100 mg/kg) of Vernonia amygdalina leaves extract can be accommodated by rat testis, the higher doses (300 mg/kg and 600 mg/kg) demonstrate testicular toxicity in the rat.

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Section: Discussionsupporting

confidence: 83%

The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity

2013

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“…A number of known sesquiterpene lactones, and 13 new stigmastane-type steroid glucosides and their freely occurring aglycones, have been isolated (Ohigashi et al 1991, Jisaka et al 1992a, 1992b, 1993a, 1993b sesquiterpene lactones present in V. amygdalina are also found in V. colorata and in a number of other Vernonia species. They are well known for their anthelmintic, antiamoebic, antitumor, and antibiotic properties (Toubiana and Gaudemer 1967, Kupchan et al 1969, Asaka et al 1977, Gasquet et al 1985, Jisaka et al 1992a, 1993b.…”

Section: Ethnomedicinal and Phytochemical Evidence For The Pharmacolomentioning

confidence: 99%

Self-Medicative Behavior in the African Great Apes: An Evolutionary Perspective into the Origins of Human Traditional Medicine

Huffman¹

2001

BioScience

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152

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“…It is widely accepted that diets rich in fruits and plants are rich sources of different types of antioxidants; phenolic compounds are the most studied of these and have been recognized to possess a wide range of properties including antioxidant, antibacterial, anti-inflammatory, hepatoprotective, and anticarcinogenic actions [3,4,63]. Many of the biological functions of flavonoid, phenolic, catechin, curcumin, resveratrol, and genistein compounds have been attributed to their free-radical scavenging, metal-ion chelating, and antioxidant activities [118,152].…”

Section: Antioxidants In Cancer Assaysmentioning

confidence: 99%

The Role of Natural Antioxidants in Cancer Disease

Moreno¹

2013

Oxidative Stress and Chronic Degenerative Diseases - A Role for Antioxidants

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Steroid glucosides from vernonia amygdalina, a possible chimpanzee medicinal plant

Cited by 92 publications

References 5 publications

The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity

The Histo-morphometric Evidences of Vernonia amygdalina Leaf Extract-induced Testicular Toxicity

Self-Medicative Behavior in the African Great Apes: An Evolutionary Perspective into the Origins of Human Traditional Medicine

The Role of Natural Antioxidants in Cancer Disease

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