Steroid-induced glaucoma

Clark, Abbot F.; Zhang, Xinyu; Yorio, Thomas

doi:10.1016/b978-0-7020-2983-7.00019-x

Cited by 6 publications

(8 citation statements)

References 112 publications

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“…2, 3 Steroid induced IOP elevation is a well described phenomenon that has been reported to occur typically a few weeks after exposure to corticosteroids. 4–6 Detection of a substantial IOP increase at the 4-day post injection visit in a few study participants reported from this study was unexpected and, to our knowledge, previously unreported. The reasons for elevated IOP in this time frame are unclear.…”

Section: Commentmentioning

confidence: 53%

Frequency of Intraocular Pressure Increase Within Days After Intravitreal Triamcinolone Injections in the Diabetic Retinopathy Clinical Research Network

2011

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Section: Commentmentioning

confidence: 53%

Frequency of Intraocular Pressure Increase Within Days After Intravitreal Triamcinolone Injections in the Diabetic Retinopathy Clinical Research Network

2011

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“…In any case, these conventional formulations require frequent instillation of large doses to compensate low ocular bioavailability due to rapid pre-corneal elimination and non-productive absorption via nasolacrimal drainage. Corticosteroids unwanted ocular side effects could rapidly develop due to dose fluctuations and direct exposure to the ocular tissues (Clark, 1995;Clark et al, 2011). For instance, topical administration of hydrocortisone, prednisolone or dexamethasone nano-suspensions were associated with both enhanced ocular bioavailability and parallel rising in the IOP, compared with the micro-sized suspensions and solutions due to enhancement of solubility and in vivo dissolution rates of hydrocortisone, prednisolone or dexamethasone (Kassem et al, 2007).…”

Section: Introductionmentioning

confidence: 98%

Preparation, characterization and evaluation of novel elastic nano-sized niosomes (ethoniosomes) for ocular delivery of prednisolone

Gaafar

Abdallah

Farid

et al. 2014

Journal of Liposome Research

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Niosomes embodying ethanol and minimum amount of cholesterol (ethoniosomes) could be promising ocular delivery systems for water soluble and insoluble drugs. This manuscript reports on novel nano-sized elastic niosomes (ethoniosomes) composed of Span 60: cholesterol (7:3 mol/mol) and ethanol, for ocular delivery of prednisolone acetate (Pred A) and prednisolone sodium phosphate (Pred P). These ethoniosomes were prepared with the thin film hydration (TFH) and ethanol injection (EI) methods, characterized for percentage entrapment efficiency (% EE), size, zeta potential, morphology, elasticity, in vitro release and physical stability. Ocular irritation, bioavailability and anti-inflammatory effects were evaluated and compared with the conventional suspension and solution eye drops. The prepared ethoniosomal vesicles (EV) had a Z-average diameter of 267 nm, zeta potential of approximately -40 mV and % change in size after extrusion of 4%. They were physically stable for at least 2 months at 4 °C. The prepared EV showed good ocular tolerability using the modified Draize's test and the estimated relative ocular bioavailability for Pred A EV and Pred P EV was 1.54 and 1.75 times greater than that for the suspension and solution eye drops, respectively. The time required for complete healing from the clove oil-induced severe ocular inflammation was reduced to half with Pred A and Pred P EV. More interestingly, the intraocular pressure (IOP) elevation side effect recorded for Pred A and Pred P EV was significantly less than that for the conventional suspension and solution eye drops.

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“…Hence, in the present experiments it was possible to measure the time collapse changes as a function of the external pressure. Because of medical reasons, the interest pressure range for this group is the IOP range, i.e., the range between 9 mmHg and 60 mmHg [20] . The Rayleigh model [26] describes the bubble wall radius change U = dR/dt during the bubble collapse, assuming the liquid has an infinite extent (i.e., in which the bubble size is negligible in comparison with the water volume) and is uncompressible, as is the case here:…”

Section: Collapse Time and External Liquid Pressurementioning

confidence: 99%

“…This is the case of patients with steroid-induced glaucoma, characterized by highly elevated IOP often in the 30 to 60 mmHg range [20] and it is important to understand the behavior of the laser-induced cavitation phenomenon in water in a pressure range comparable to the abnormal IOP.…”

Section: Introductionmentioning

confidence: 99%

Laser-induced cavitation phenomenon studied using three different optically-based approaches – An initial overview of results

Devia-Cruz

Camacho‐López

Evans

et al. 2012

Photonics &Amp; Lasers in Medicine

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This report presents a study of shock wave and cavitation bubble dynamics induced by nanosecond laser pulses in pressurized water. Three methods were used to obtain data from the irradiated sample: (1) pump-probe laser flash shadowgraphy, (2) pressure wave sensing by means of a fiber optic interferometer hydrophone, and (3) a novel technique based on the modulation of spatial transmittance by the cavitation bubble. The medium used in these experiments was distilled water in a chamber under different pressure conditions which included values found in human intraocular liquid. It could be shown that while external pressure does not affect either the shock wave propagation or the initial bubble growth rate, it does affect the first collapse time of the bubble and its maximum diameter.Keywords: bubble; shock wave; microsurgery; pressure; intraocular.Zusammenfassung : Die vorliegende Arbeit untersucht die Dynamik von Schockwellen und Kavitationsblasen, die mittels Nanosekunden-Laserpulsen in unter Druck gesetztem Wasser erzeugt wurden. Dabei wurden drei unterschiedliche Methoden verwendet: (1) Laserflash-Verfahren, (2) Druckwellenmessung mittels faseroptischem Interferometer und (3) eine neuartige Technik basierend auf der Modulation der r ä umlichen Transmission durch die Kavitationsblase. Die Untersuchungen wurden an destilliertem Wasser unter unterschiedlichen Dr ü cken -u.a. auch physiologische Werte, wie sie intraokular vorkommen -vorgenommen, die mittels einer speziellen Druckkammer erzeugt wurden. Es konnte gezeigt werden, dass weder die Ausbreitung der Schockwelle noch das anf ä ngliche Blasenwachstum durch den ä u ß eren Druck beeinflusst wird, die Kollapszeit der Blase und ihr maximaler Durchmesser jedoch sehr wohl.Schl ü sselw ö rter: Blase; Schockwelle; Mikrochirurgie; Druck; intraokular.

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Steroid-induced glaucoma

Cited by 6 publications

References 112 publications

Frequency of Intraocular Pressure Increase Within Days After Intravitreal Triamcinolone Injections in the Diabetic Retinopathy Clinical Research Network

Frequency of Intraocular Pressure Increase Within Days After Intravitreal Triamcinolone Injections in the Diabetic Retinopathy Clinical Research Network

Preparation, characterization and evaluation of novel elastic nano-sized niosomes (ethoniosomes) for ocular delivery of prednisolone

Laser-induced cavitation phenomenon studied using three different optically-based approaches – An initial overview of results

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