Steroid regulation of menstrual bleeding and endometrial repair

Maybin, Jacqueline A; Critchley, Hilary

doi:10.1007/s11154-012-9228-2

Cited by 28 publications

(23 citation statements)

References 113 publications

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“…We hypothesize that the effects of estrogen on endometrial tissues are uncontrolled in individuals lacking sufficient amounts of progesterone. During pregnancy, progesterone inhibits menstruation (24). The cell damage, repair, and injury responses in endometrial epithelial cells shut down, and the risk of developing endometrial cancer during pregnancy is reduced.…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of FXYD3 in endometrial cancer

Zhang

et al. 2014

Oncology Letters

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FXYD3 expression is upregulated in numerous cancer cell types. The present study compared the FXDY3 expression in normal endometrium, premalignant lesion and endometrial cancer tissue samples, and investigated the correlation between FXDY3 expression and clinicopathological features. FXYD3 expression was analyzed by streptavidin-peroxidase immunohistochemistry in 21 normal endometrial tissue samples, 18 atypical endometrial hyperplasia samples and 50 tissues obtained from patients diagnosed with endometrial cancer. The percentage of FXYD3-positive cell expression in the normal endometrium, atypical hyperplasia and endometrial cancer tissues samples was 0, 22, and 26%, respectively. The differences between the atypical hyperplasia and endometrial cancer groups were statistically significant when compared with the normal group (P=0.007 and P=0.037, respectively). There was no significant difference between the atypical hyperplasia and endometrial cancer groups. The percentage of FXYD3-positive cells correlated with the fertility frequency (P<0.05). In conclusion, FXYD3 is a potential biomarker for endometrial cancer, and its upregulation may be an early event in endometrial carcinoma progression. In addition, FXYD3 expression in endometrial carcinoma correlates with fertility frequency.

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Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of FXYD3 in endometrial cancer

Zhang

et al. 2014

Oncology Letters

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“…Up-regulation of E 2 and ERα can reduce inflammatory response 29,30) and promote endometrial repair. 31) According to previous reports, the ingredients of TSD, for example, oleic and linolenic acid, 9,32) catalpol, 33) amygdalin, 34) caffeic, chlorogenic and ferulic acid, 35,36) can elevate the E 2 levels. Likewise, the ingredients of TSD, such as Z-ligustilide, 10) ferulic acid, 37) tetramethylpyrazine hydrochloride, 38) paeoniflorin, 38) can elevate the ERα levels.…”

Section: Tsd Promoted the Endometrial Repairmentioning

confidence: 96%

Protective Effect of Taohong Siwu Decoction on Abnormal Uterine Bleeding Induced by Incomplete Medical Abortion in Rats during Early Pregnancy

et al. 2018

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Abnormal uterine bleeding (AUB) induced by incomplete abortion is a common gynecological disease. Taohong Siwu decoction (TSD) is a traditional Chinese medicine (TCM) formula, which has been developed to treat AUB for hundreds of years. In this study, rats had incomplete abortion induced in early pregnancy using mifepristone and misoprostol. The duration and quantity of uterine bleeding were recorded and measured. The pathologic histologic grade was evaluated by hematoxylin-eosin staining (HE). Estradiol (E 2 ) and progesterone (P) levels were measured by enzyme linked immunosorbent assays (ELISA). The expression levels of estrogen receptor alpha (ERα) and progesterone receptor (PR) were detected by immunohistochemistry and Western blotting analysis. We demonstrated that TSD significantly reduced the duration and quantity of uterine bleeding. Meanwhile, TSD promoted endometrial repair and significantly up-regulated the E 2 levels and the ERα expression. These results suggest that TSD have a protective effect on the uteri; the mechanism may be concerned with up-regulation of the levels of E 2 and the ERα expression.Key words abnormal uterine bleeding; incomplete medical abortion; estrogen; Taohong Siwu decoction Medical abortion induced by mifepristone and misoprostol is a very common procedure in reproductive health. Medical abortion is considered to be less painful and more efficient and convenient method comparing with surgical abortion, which has been accepted by many women who want to terminate the pregnancy. However, one of great side effects of medical abortion is incomplete abortion, which may cause abnormal uterine bleeding (AUB) at any time. 1,2) AUB, affecting up to one-third of women of child bearing age, will interfere with the physical, emotional, and social QOL of women.3,4) Patients with clinically diagnosed AUB were treated by means of medicines or operations. Surgical treatments are suggested in the presence of medical therapies failure, which cause severe anemia, and other accompanying uterine pathology because of the influence on fertility. For medical options, the management of AUB can be divided into hormonal and non-hormonal therapies. Non-hormonal, including non-steroidal anti-inflammatory drugs (NSAIDs) and anti-fibrinolytics, has not achieved any effective treatment outcomes. 5,6) The selection of hormonal therapy mainly depends on the patients' preferences. The combined oral contraceptive pills are widely used to regulate bleeding and reduce blood loss, although side effects may limit longer term use.Traditional Chinese medicine (TCM) therapy has advantages and provides an alternative option in treating the AUB patients. Taohong Siwu decoction (TSD) as a TCM formula has been developed to treat AUB for hundreds of years, which was first recorded in a well-known medical book Yizong Jinjian (Golden Mirror of Medicine, 1749) (Qing Dynasty of China) by Wu Qian and widely used for postpartum hemorrhage with a history of several centuries. It is still used in treating AUB patients in clinics.7...

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“…Granulosa cells from the ovulated follicle differentiate to form the corpus luteum, which produces progesterone (17) that regulates downstream reproductive function and maintains crosstalk with the pituitary. Progesterone from the ovary signals to the rest of the reproductive tract to induce changes that facilitate oocyte transport and implantation (19). The luteal phase lasts approximately 12 days in women, during which time the corpus luteum degrades and the next set of primordial follicles is selected for activation.…”

Section: Female Reproductive Tractmentioning

confidence: 99%

Microphysiological modeling of the reproductive tract: A fertile endeavor

Eddie

Kim

Woodruff

et al. 2014

Exp Biol Med (Maywood)

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Preclinical toxicity testing in animal models is a cornerstone of the drug development process, yet it is often unable to predict adverse effects and tolerability issues in human subjects. Species-specific responses to investigational drugs has led researchers to utilize human tissues and cells to better estimate human toxicity. Unfortunately, human cell-derived models are imperfect because toxicity is assessed in isolation, removed from the normal physiologic microenvironment. Microphysiological modeling, often referred to as ‘organ-on-a-chip’ or ‘human-on-a-chip’ places human tissue into a microfluidic system that mimics the complexity of human in vivo physiology, thereby allowing for toxicity testing on several cell types, tissues, and organs within a more biologically relevant environment. Here we describe important concepts when developing a repro-on-a-chip model. The development of female and male reproductive microfluidic systems is critical to sex-based in vitro toxicity and drug testing. This review addresses the biological and physiological aspects of the male and female reproductive systems in vivo and what should be considered when designing a microphysiological human-on-a-chip model. Additionally, interactions between the reproductive tract and other systems are explored, focusing on the impact of factors and hormones produced by the reproductive tract and disease pathophysiology.

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Steroid regulation of menstrual bleeding and endometrial repair

Cited by 28 publications

References 113 publications

Expression and clinical significance of FXYD3 in endometrial cancer

Expression and clinical significance of FXYD3 in endometrial cancer

Protective Effect of Taohong Siwu Decoction on Abnormal Uterine Bleeding Induced by Incomplete Medical Abortion in Rats during Early Pregnancy

Microphysiological modeling of the reproductive tract: A fertile endeavor

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