Steroid t-butyldimethylsilyl ethers as derivatives for mass fragmentography

Phillipou, G.; Bigham, Diane; Seamark, R.F.

doi:10.1016/0039-128x(75)90071-9

Cited by 62 publications

(6 citation statements)

References 5 publications

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“…The very stable tert ‐butyl radical results in most of the spectra of TBDMS derivatized compounds displaying very abundant [M − tert ‐C 4 H 9 • ] + ([M − 57] + ) ions (Millington, ; Ogilvie, ; Phillipou et al, ; Watson & Sweetman, ). A typical spectrum is shown in Figure c, Consequently, these derivatives are favourites for selected ion monitoring work and a large number of applications have been published up to the present day (Arkan & Molnár‐Perl, ).…”

Section: Other Silyl Derivativesmentioning

confidence: 99%

“…• ] + ([M − 57] + ) ions (Millington, 1975;Ogilvie, 1973;Phillipou et al, 1976;Watson & Sweetman, 1974). A typical spectrum is shown in Figure 75c, Consequently, these derivatives are favourites for selected ion monitoring work and a large number of applications have been published up to the present day (Arkan & Molnár-Perl, 2017).…”

Section: Ivd2 Tert-butyldimethylsilyl (Tbdms) Derivativesmentioning

confidence: 99%

“…Where no other hydroxyl function is present in the steroid, such as in pregn-4en-3,20-dione, the 3-enol-TBDMS derivative gives the molecular ion as the base peak with no other ion more abundant than 10% (Kelly & Taylor, 1976). Estrogens also give a reasonably abundant molecular ion (Phillipou et al, 1976;Shareef et al, 2004) but most other steroids give abundant [M − 57] + ions with little or no molecular ion (Phillipou et al, 1976).…”

Section: Ivd2 Tert-butyldimethylsilyl (Tbdms) Derivativesmentioning

confidence: 99%

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Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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This review describes the mass spectral fragmentation of trimethylsilyl (TMS) and related alkylsilyl derivatives used for preparing samples for analysis, mainly by combined gas chromatography and mass spectrometry (GC/MS). The review is divided into three sections. The first section is concerned with the TMS derivatives themselves and describes fragmentation of derivatized alcohols, thiols, amines, ketones, carboxylic acids and bifunctional compounds such as hydroxy‐ and amino‐acids, halo acids and hydroxy ethers. More complex compounds such as glycerides, sphingolipids, carbohydrates, organic phosphates, phosphonates, steroids, vitamin D, cannabinoids, and prostaglandins are discussed next. The second section describes intermolecular reactions of siliconium ions such as the TMS cation and the third section discusses other alkylsilyl derivatives. Among these latter compounds are di‐ and trialkyl‐silyl derivatives, various substituted‐alkyldimethylsilyl derivatives such as the tert‐butyldimethylsilyl ethers, cyclic silyl derivatives, alkoxysilyl derivatives, and 3‐pyridylmethyldimethylsilyl esters used for double bond location in fatty acid spectra. © 2019 Wiley Periodicals, Inc. Mass Spec Rev 0000:1–107, 2019

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Section: Other Silyl Derivativesmentioning

confidence: 99%

Section: Ivd2 Tert-butyldimethylsilyl (Tbdms) Derivativesmentioning

confidence: 99%

Section: Ivd2 Tert-butyldimethylsilyl (Tbdms) Derivativesmentioning

confidence: 99%

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Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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“…Recently, the tert-butyldimethylsilyl (TBDMSi) group has been employed for GC, SIM, and MS of prostaglandins (7,8), steroids (9)(10)(11)(12)(13)(14), carbohydrates (15)(16)(17), fatty acids (18), and nucleosides (19)(20)(21). This group forms one member of a series of "sterically crowded trialkylsilyl" (SCTASi) groups which we have been studying.…”

mentioning

confidence: 99%

Sterically crowded trialkylsilyl derivatives for chromatography and mass spectrometry of biologically-important compounds

Quilliam¹,

Westmore²

1978

Anal. Chem.

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“…The gas chromatograph was equipped with a glass column (3 m x 3.5 mm, i.d.) of 1% OV-1 on Gas Chrom Q (100-120 3 mesh) at 270°C. Syn and anti isomers of the methyl oximes were not separated.…”

Section: Introductionmentioning

confidence: 99%

Gas chromatography mass spectrometry of androstanolones as methyl oxime,tert-butyldimethylsilyl ether derivatives

Gaskell¹,

Pike²

1981

Biol. Mass Spectrom.

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Steroid t-butyldimethylsilyl ethers as derivatives for mass fragmentography

Cited by 62 publications

References 5 publications

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Sterically crowded trialkylsilyl derivatives for chromatography and mass spectrometry of biologically-important compounds

Gas chromatography mass spectrometry of androstanolones as methyl oxime,tert-butyldimethylsilyl ether derivatives

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