Steroidal Constituents from the Soft Coral Sinularia dissecta and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells

Steroid Constituents from the Soft Coral <i>Sinularia nanolobata</i>

“…1) after subjecting it on various chromatographic separations. Detailed analysis of the spectroscopic data one and two dimensional (1D-and 2D)-NMR and MS and comparison with literature values led to elucidation of the known compounds as dissesterol (3), 11) 3β-hydroxy-24-methylenecholest-5-en-7-one (4), 12,13) 16α-hydroxysarcosterol (5), 10) and sarcophytosterol (6). 14) Compound 1 was isolated as a colorless powder with the molecular formula C 28 (Fig.…”

Anti-Inflammatory Components of the Starfish Astropecten polyacanthus

“…In previous studies, we isolated and identified seven steroids ( 1 – 7 ) from A. polyacanthus (Figure 1), some of which had cytotoxic effects against HL-60 (leukemia), PC-3 (prostate), and SNU-C5 (colorectal) human cancer cells [17]. In continuation of our investigations on Vietnamese marine organisms regarding anti-inflammatory activity [18,19,20,21], we found that the MeOH extract and CH 2 Cl 2 partition showed significant in vitro anti-inflammatory activities. The present study deals with the inhibitory capacity of steroids isolated from the starfish A. polyacanthus on LPS-induced expression of the pro-inflammatory cytokines IL-12 p40, IL-6, and TNF-α in bone marrow-derived dendritic cells.…”

Inhibition of NF-κB transcriptional activation in HepG2 cells by diterpenoids from the soft coral Sinularia maxima

“…Previous studies have indicated that diterpenes, a main constituent of the genus Sinularia , exhibit various biological activities, such as anti-inflammatory (Chao et al 2011; Cheng et al 2010; Lu et al 2010; Su and Wen 2011), antiviral (Cheng et al 2010), and cytotoxic (Grote et al 2008; Kamel et al 2007; Lo et al 2009; Su et al 2009) effects. As a part of our ongoing investigations on screening active compounds from Vietnamese Sinularia soft corals towards anti-inflammatory effects (Thao et al 2012, 2013a, b), we recently reported the isolation, structure elucidation, and inhibitory effects on lipopolysaccharide-stimulated production of proinflammatory cytokines in bone marrow-derived dendritic cells of 12 diterpenoids [sinumaximol A ( 1 ), sinumaximol B ( 2 ), sinumaximol C ( 3 ), sethukarailin ( 4 ), sinumaximol D ( 5 ), sinumaximol E ( 6 ), sinumaximol F ( 7 ), sinumaximol G ( 8 ), sinumaximol H ( 9 ), (1 S ,2 E ,4 S ,6 E ,8 S ,11 R )-2,6,12(20)-cembratriene-4,8,11-triol ( 10 ), isomandapamate ( 11 ), and sinumaximol I ( 12 )] (Thao et al 2012) and 7 norditerpenoids [scabrolide A ( 13 ), 12-hydroxy-scabrolide A ( 14 ), yonarolide ( 15 ), ineleganolide ( 16 ), 5-epinorcembrene ( 17 ), 13- epi -scabrolide C ( 18 ), and norcembrene 5 ( 19 )] (Thao et al 2013a) from Sinularia maxima (see Fig. 1).…”