Steroidal saponins from Smilax china and their anti-inflammatory activities

Shao, Bo; Guo, Hongzhu; Cui, Yaokui; Ye, Min; Han, Jian; Guo, Dan

doi:10.1016/j.phytochem.2006.10.026

Cited by 136 publications

(71 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…showed that these plants are a rich source of steroidal saponins, as well as sulphur-containing compounds (Hostettmann & Marston, 1995;Iciek, Kwiecien, & Wlodek, 2009;Lanzotti, 2005). The steroidal saponins, an important class of natural products, have been reported to possess various important biological effects, such as haemolytic , antifungal (Barile et al, 2007;Sautour, Miyamoto, & Lacaille-Dubois, 2007), antidiabetic (Yoshikawa et al, 2007), platelet aggregation inhibitory (Zhang et al, 1999), anti-inflammatory (Shao et al, 2007) and immunomodulatory activities (Lacaille-Dubois, 2005;Zhang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Spirostane and cholestane glycosides from the bulbs of Allium nigrum L

et al. 2011

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Spirostane and cholestane glycosides from the bulbs of Allium nigrum L

et al. 2011

View full text Add to dashboard Cite

“…22,23 Some literature also indicates that saponins in S. china L. showed excellent bioactivities with antitumor and anti-inflammatory effects. 32,33 Among the saponins, diosgenin, which was also found in FMR, is a safe and efficacious chemopreventive agent against a series of human cancers. Its anticancer activity involves a variety of molecular and cellular targets, including cell cycle arrest, suppression of the signal transducer and activator of transcription 3 pathway, and activation of caspase-3 and p53, and it can also reduce the expression of signal transducer and activator of transcription 3-regulated gene products, like vascular endothelial growth factor, Bcl-2, Bcl-xL, etc.…”

Section: Discussionmentioning

confidence: 99%

Fraction of Macroporous Resin from Smilax china L. Inhibits Testosterone Propionate–Induced Prostatic Hyperplasia in Castrated Rats

Chen

Xiong²,

Song³

et al. 2012

Journal of Medicinal Food

View full text Add to dashboard Cite

The present study was conducted to evaluate the effect of a fraction of macroporous resin (FMR), a bioactive component of Smilax china L., on benign prostatic hyperplasia (BPH) in castrated rats induced by testosterone propionate. Rats were randomly divided into five groups: the negative control group (sham-operated), the model group, two FMR-treated groups (at doses of 300 mg/kg and 600 mg/kg of body weight), and the positive control group (treated with finasteride at the dose of 3 mg/kg). Drugs were administered once a day for three consecutive weeks by gastric gavage. Prostates were weighed, testosterone and dihydrotestosterone (DHT) levels in serum were determined, and histopathological examinations were carried out. FMR treatment inhibited prostatic hyperplasia, reducing the DHT level in serum and improving the prostate gland morphology compared with the model group. The overall results of this study suggest that FMR is effective at inhibiting experimentally induced prostate enlargement, and it presents a valuable resource for the treatment of human BPH.KEY WORDS: benign prostatic hyperplasia dihydrotestosterone fraction of macroporous resin Smilax china L.

show abstract

“…Previous phytochemical studies of this genus focused on Smilax china, Smilax macrophylla, Smilax riparia, Smilax glabra, and Smilax bracteata, and have led to the isolation of some characteristic steroidal saponins, flavonoids and lignans [4][5][6][7][8]. However, to our best knowledge, until now, no literature was reported on constituents isolated from S. trinervula.…”

Section: Introductionmentioning

confidence: 99%