Steroidal Saponins from the Roots and Rhizomes of  Tupistra chinensis

Li, Yuze; Wang, Xin; He, Hao; Zhang, Dongdong; Jiang, Yi; Yang, Xinjie; Wang, Fei; Tang, Zhishu; Song, Xiaomei; Yue, Zhenggang

doi:10.3390/molecules200813659

Cited by 25 publications

(14 citation statements)

References 16 publications

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“…Transcriptome analysis of medicinal plants whose genomic information is Li et al (2015aLi et al ( , 2015c 177. Spirostane-type saponins Dracaena fragrans Bark, Roots and leaves Rezgui et al (2015) not available in public databases helps in the identification of prospective candidate genes involved in the biosynthesis of the secondary metabolic pathway and this will further increase our understanding related to biosynthesis, regulation, and diversity of secondary metabolites.…”

Section: Transcriptome Analysis Of Medicinal Plants That Produce Stermentioning

confidence: 99%

Recent advances in steroidal saponins biosynthesis and in vitro production

Upadhyay

Jeena

Shikha

et al. 2018

Planta

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Main conclusion Steroidal saponins exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponins are not sufficient for utilizing them for commercial purpose so in vitro production of saponin by tissue culture, root culture, embryo culture, etc, is necessary for its large-scale production.Saponin glycosides are the important class of plant secondary metabolites, which consists of either steroidal or terpenoidal backbone. Due to the existence of a wide range of medicinal properties, saponin glycosides are pharmacologically very important. This review is focused on important medicinal properties of steroidal saponin, its occurrence, and biosynthesis. In addition to this, some recently identified plants containing steroidal saponins in different parts were summarized. The high throughput transcriptome sequencing approach elaborates our understanding related to the secondary metabolic pathway and its regulation even in the absence of adequate genomic information of non-model plants. The aim of this review is to encapsulate the information related to applications of steroidal saponin and its biosynthetic enzymes specially P450s and UGTs that are involved at later stage modifications of saponin backbone. Lastly, we discussed the in vitro production of steroidal saponin as the plant-based production of saponin is time-consuming and yield a limited amount of saponins. A large amount of plant material has been used to increase the production of steroidal saponin by employing in vitro culture technique, which has received a lot of attention in past two decades and provides a way to conserve medicinal plants as well as to escape them for being endangered.

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Section: Transcriptome Analysis Of Medicinal Plants That Produce Stermentioning

confidence: 99%

Recent advances in steroidal saponins biosynthesis and in vitro production

Upadhyay

Jeena

Shikha

et al. 2018

Planta

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“…This inference was confirmed by detailed analysis of the 2D NMR data. The proton and protonated carbon resonances in the NMR spectra of 1 were unambiguously assigned by the HSQC experiments [11,12,13,14]. The 1 H- 1 H COSY correlations of H-4′/H-5′/H-6′/H-7′, along with HMBC correlations (Figure 2) of NH-1′/C-2′, C-3′ and C-7′a, indicate a 1 H -indol-2-one unit in 1 [15]; 1 H- 1 H COSY correlations of H-2″/H-3″/H-4″/H-5″, along with the HMBC correlations of H-2″/C-3″ and C-5″, indicated a pyrrolidine unit in 1 [16]; 1 H- 1 H COSY correlations of H-5/H6/H7/H8, along with the HMBC correlations of H-2/C-3 and C-4, H-5/C-4 and C-8a and the remaining molecular formula C 10 H 5 NO, indicated a 4-quinolinecarboxylic acid unit in 1 [17].…”

Section: Resultsmentioning

confidence: 99%

Alkaloid Enantiomers from the Roots of Isatis indigotica

Zhang

Shi

et al. 2019

Molecules

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Five pairs of alkaloid enantiomers (1a/1b–5a/5b) were obtained from Isatis indigotica (I. indigotica) roots. Among them, 1a/1b, 2a/2b and 3a/3b were determined as three pairs of new alkaloid enantiomers. Their structures were elucidated by physicochemical properties and spectroscopic methods. The absolute configurations were deduced by comparison of their experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra, as well as by single-crystal X-ray crystallography using anomalous scattering of Cu Kα radiation. Alkaloids 1a and 1b possess an unpresented carbon skeleton and their putative biosynthetic pathways are discussed. Moreover, all of the alkaloids were tested for their nitric oxide (NO) inhibitory effects in RAW 264.7 cells, and 4a and 4b showed inhibitory effects with IC50 values of 76.97 μM and 65.88 μM, respectively.

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“…Previous investigations of the bioactive compounds of S. japonica revealed four steroidal saponins [ 6 , 7 , 8 ]. As part of our exploration of the diversity of bioactive compounds in medicinal herbs growing in the Qinba Mountains [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ], we investigated the chemical constituents of S. japonica in the present study. We identified six steroidal constituents ( Figure 1 ), characterized their structure and pharmacological profiles, and evaluated their cytotoxicity against various human cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Steroidal Constituents from Roots and Rhizomes of Smilacina japonica

et al. 2018

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Four new steroidal constituents (1–4) along with two known steroidal glycosides (5 and 6) were isolated from the roots and rhizomes of Smilacina japonica. Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25S)-5α-spirostan-9(11)-en-3β, 17α-diol (1); (25S)-5α-spirostan-9(11)-en-3β, 12β-diol (2); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranoside (3); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-galactopyranoside (4); japonicoside B (5); and japonicoside C (6). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells.

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Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis

Cited by 25 publications

References 16 publications

Recent advances in steroidal saponins biosynthesis and in vitro production

Recent advances in steroidal saponins biosynthesis and in vitro production

Alkaloid Enantiomers from the Roots of Isatis indigotica

Steroidal Constituents from Roots and Rhizomes of Smilacina japonica

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