2004
DOI: 10.1016/j.reprotox.2003.10.011
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Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats

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Cited by 136 publications
(86 citation statements)
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“…The phthalates with sidechain length C4 to C6 produce similar severe reproductive effects in experimental animals. Steroidogenesis in foetal rats is reduced by DEHP ex vivo and DINP, DBP, DIBP, and DEHP seem to reduce testicular testosterone production by a similar mechanism of action , Borch et al 2004, Borch et al 2006). In addition, plasma LH levels in male foetuses were elevated (Borch et al 2004).…”
Section: Mechanisms Of Action Of Dehpmentioning
confidence: 96%
See 2 more Smart Citations
“…The phthalates with sidechain length C4 to C6 produce similar severe reproductive effects in experimental animals. Steroidogenesis in foetal rats is reduced by DEHP ex vivo and DINP, DBP, DIBP, and DEHP seem to reduce testicular testosterone production by a similar mechanism of action , Borch et al 2004, Borch et al 2006). In addition, plasma LH levels in male foetuses were elevated (Borch et al 2004).…”
Section: Mechanisms Of Action Of Dehpmentioning
confidence: 96%
“…Steroidogenesis in foetal rats is reduced by DEHP ex vivo and DINP, DBP, DIBP, and DEHP seem to reduce testicular testosterone production by a similar mechanism of action , Borch et al 2004, Borch et al 2006). In addition, plasma LH levels in male foetuses were elevated (Borch et al 2004). Immunohistochemistry showed a clear reduction in the nuclear receptor steroidogenic factor-1 (SF-1) and peroxisome proliferator PPAR gamma after gavage administration of 300 mg/kg bw/day DEHP (Borch et al 2006b).…”
Section: Mechanisms Of Action Of Dehpmentioning
confidence: 96%
See 1 more Smart Citation
“…The phthalates with side-chain length C4 to C6 produce similar severe reproductive effects in experimental animals. Steroidogenesis in foetal rats is reduced by DEHP ex vivo and DINP, DBP, DIBP, and DEHP seem to reduce testicular testosterone production by a similar mechanism of action Borch et al 2004;Borch et al 2006a). In addition, plasma LH levels in male foetuses were elevated (Borch et al 2004).…”
Section: Mechanisms Of Action Of Dehpmentioning
confidence: 99%
“…Steroidogenesis in foetal rats is reduced by DEHP ex vivo and DINP, DBP, DIBP, and DEHP seem to reduce testicular testosterone production by a similar mechanism of action Borch et al 2004;Borch et al 2006a). In addition, plasma LH levels in male foetuses were elevated (Borch et al 2004). Immunohistochemistry showed a clear reduction in the nuclear receptor steroidogenic factor-1 (SF-1) and peroxisome proliferator PPAR gamma after gavage administration of 300 mg/kg bw/day DEHP (Borch et al 2006b).…”
Section: Mechanisms Of Action Of Dehpmentioning
confidence: 99%