Stevens Johnson Syndrome Initiated by an Adverse Reaction to Trimethoprim-Sulfamethoxazole

Abstract

The authors present a case of a 54-year-old male who presented to the ED with Stevens Johnson syndrome (SJS) beginning on his upper lips, then spreading to his glans penis, airway, and buttocks. After using trimethoprim-sulfamethoxazole (TMP-SMX) to treat a pilonidal cyst diagnosed seven days prior to presentation, the patient began to have desquamating lesions on his upper and lower lips. Subsequently, he noticed desquamation on the glans penis and then between his buttocks. Before being referred to dermatology, he was treated with a high dosage of corticosteroids.

Prevention of infective complications in systemic lupus erythematosus: A systematic literature review for the APLAR consensus statements

“…Trimethoprim/sulfamethoxazole (TMP/SMX) remains the first‐line drug of choice for prophylaxis and treatment of PJP. Several studies highlighted a higher incidence of more severe side effects to TMP/SMX in the Asian population 69,70 . The efficacy of alternative drugs is uncertain but they are often used in combination with TMP/SMX.…”

The Impact of Patient Age and Corticosteroids in Patients With Sulfonamide Hepatotoxicity

“…These data confirm previous studies that TMP-SMZ hepatotoxicity is more likely to occur in malnourished patients with untreated advanced HIV infection. Previous studies have also demonstrated an association of TMP-SMZ with Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug eruption with eosinophilia and systemic symptoms (22,23). However, only 2 of our 105 cases had Stevens-Johnson syndrome with neither having HIV infection and none had drug eruption with eosinophilia and systemic symptoms.…”