Stevens-Johnson syndrome/toxic epidermal necrolysis presumably induced by norfloxacin

Maciejewska, Jolanta; Jankowski, Marek; Zegarska, Barbara; Czajkowski, Rafał

doi:10.5114/pdia.2014.40796

Cited by 9 publications

(12 citation statements)

References 11 publications

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“…Toute population confondue, Les NET et les SSJ seraient provoqués dans 72 à 90% des cas par un médicament [2]. Plus précisément, la littérature mentionne plusieurs cas de toxidermie bulleuse (NET ou SSJ) sous fluoroquinolones (ciprofloxacine, ofloxacine, levofloxacine, norfloxacine, moxifloxacine) chez des patients adultes [7][8][9][10][11]. Cependant, dans la population pédiatrique, nous n'avons pas trouvé de cas de NET ou SSJ sous fluoroquinolone.…”

Section: Discussionunclassified

Fatal case of toxic epidermal necrolysis induced by ciproflfl oxacin in a child

Schiestel¹

2021

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Bullous drug eruptions such as Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but known adverse reactions of fluoroquinolones. Although uncommon, TEN can be life-threatening for the patient, especially in the context of delayed treatment and in fragile patients such as the pediatric population. In the present case, TEN occurred in a 13-year-old girl with no medical history following initiation of ciprofloxacin treatment for an inguinal cyst. We hope that the case report will make interrogate the practices concerning the use of antibiotics, in particular fluoroquinolones in the context of an use not prescribed by the Marketing Authorization of the drug in children.

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Section: Discussionunclassified

Fatal case of toxic epidermal necrolysis induced by ciproflfl oxacin in a child

Schiestel¹

2021

Our Dermatol Online

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“…7,8 Meskipun semua obat bisa menyebabkan SJS -NET, sebagian besar dikaitkan dengan beberapa jenis obat risiko tinggi seperti karbamazepin, fenitoin, alopurinol, lamotrigin, oxikam, obat antiinflamasi non-steroid, antibiotik golongan sulfonamid, sefalosporin, dan nevirapin. 7,8 Infeksi Mycoplasma pneumoniae dan Cytomegalovirus adalah pemicu yang paling umum pada anak-anak. 8 Pasien HIV/AIDS mempunyai risiko lebih besar terkena SSJ -NET.…”

Section: Pendahuluanunclassified

Profil Penggunaan Kortikosteroid Sistemik untuk Terapi Sindrom Stevens Johnson (SSJ) – Nekrolisis Eepidemal Toksik (NET) di Instalasi Rawat Inap RSUD DR. Moewardi Surakarta, Indonesia - Januari 2016 -Desember 2017

Irfanti

Betaubun

Fiqri

et al. 2021

CDK

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<p>Latar belakang: Nekrolisis epidermal disebut Sindrom Stevens Johnson (SSJ) apabila yang terlibat kurang dari 10% dari area tubuh, 10% sampai 29% disebut SSJ overlap NET dan lebih dari 30% NET. Tujuan : Untuk mengetahui gambaran umum pasien SSJ-NET serta penggunaan kortikosteroid sistemik di Instalasi Rawat Inap RSUD Dr. Moewardi Surakarta periode Januari 2016 – Desember 2017. Metode : Studi deskriptif retrospektif dengan populasi dan sampel penelitian pasien rawat inap di Instalasi Rawat Inap RSUD Dr. Moewardi, Surakarta, periode Januari 2016 – Desember 2017. Sampel menggunakan data sekunder dari status rekam medis di Instalasi Rawat Inap RSUD Dr. Moewardi Surakarta. Hasil: Total pasien 26 orang terutama berusia 46 – 55 tahun dan 56 – 65 tahun (23%). Laki-laki lebih banyak (57%). Diagnosis SSJ (61%) terbanyak dibandingkan SSJ overlap NET (19%) ataupun NET (19%). Hipertensi sebagai penyakit penyerta terbanyak (15%). Keterlibatan mukosa terbanyak pada mulut (88 %) dan penyebab terbanyak SSJ-NET melibatkan lebih dari satu macam obat (53%). Obat penyebab yang dicurigai terutama adalah antibiotik golongan sefalosporin dan parasetamol (23%). Rerata lama terapi deksametason adalah 10 hari dengan dosis rata-rata 25 mg per hari. Simpulan: Pengobatan kortikosteroid sistemik pada kasus SSJ – NET di RSUD dr. Moewardi Surakarta pada umumnya menghasilkan perbaikan klinis dengan rata-rata perawatan 10 hari dan dosis rata-rata deksametason 25 mg per hari.</p><p>Background: Epidermal Necrolysis is classified into several degree of severity based on the area of the body involved, below 10% is SJS, 10% - 29% is SJS overlap TEN and 30% is TEN. Objective: To provide general description of SJS-TEN patients and systemic corticosteroids therapy in Dr.Moewardi General Hospital Surakarta January 2016 - December 2017. Methods: A retrospective descriptive study on in-patients in Dr. Moewardi General Hospital Surakarta between January 2016 and December 2017. Results: Total sample was 26 patients, mostly male (57%) in 46 - 55 year-old and 56 - 65 year-old (23%). The most common diagnosis was SJS (61%) followed by SJS overlap TEN (19%) and TEN (19%). Hypertension was the most frequent comorbid disease (15%). Mostly affected was mouth mucosa (88%) and caused by mostly more than one drug (53%). Suspected causative drugs were mostly cephalosporin and paracetamol (23%). The average duration of dexamethason therapy was 10 days with an average dose 25 mg per day. Conclusion: SSJ - NET cases in Dr. Moewardi General Hospital Surakarta were mostly treated with systemic corticosteroids for an average of 10 days and an average dose of dexamethason 25 mg per day.</p>

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“…Fluoroquinolones: Ciprofloxacin induced SJS in a patient treated for otitis media reported in Sweden. [ 27 ] Norfloxacin induced SJS may appear similar to pemphigus, hence making early diagnosis a bit difficult [ 28 ].…”

Section: Drug Etiologies Associated With Sjs and Tenmentioning

confidence: 99%

Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities

Fakoya¹,

Omenyi²,

Anthony³

et al. 2018

Open Access Maced J Med Sci

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Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis are adverse hypersensitivity reactions that affect the skin and mucous membranes. They are characterised by erythematous macules and hemorrhagic erosions of the mucous membranes. Epidermal detachments of varying degrees of severity also occur in these conditions. Various aetiologies are associated with these conditions, with adverse drug reaction being the most common. Though the worldwide incidence of these conditions is recorded as low, diverse types of medication are being observed to lead to these conditions. This review compiles information on the details of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis, the pathophysiology, therapeutic management, and largely considers the drug-induced etiologies associated with these conditions.

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Stevens-Johnson syndrome/toxic epidermal necrolysis presumably induced by norfloxacin

Cited by 9 publications

References 11 publications

Fatal case of toxic epidermal necrolysis induced by ciproflfl oxacin in a child

Fatal case of toxic epidermal necrolysis induced by ciproflfl oxacin in a child

Profil Penggunaan Kortikosteroid Sistemik untuk Terapi Sindrom Stevens Johnson (SSJ) – Nekrolisis Eepidemal Toksik (NET) di Instalasi Rawat Inap RSUD DR. Moewardi Surakarta, Indonesia - Januari 2016 -Desember 2017

Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities

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