“…In situ macro-indentation testing-the preferred method for determining subchondral bone mechanical properties from various articulating bones, including the proximal tibia (Finlay et al, 1989;Harada et al, 1988;Johnston et al, 2011;Little et al, 1986;Yang et al, 1997) -may provide relevant assessments of the required E-BMD equations for input into proximal tibial FE models. In situ macro-indentation testing involves mechanical testing directly at the subchondral surface, typically with a flat cylindrical indentor (generally 3 to 4 mm in diameter), and is essentially a test of local structural stiffness.…”