Stilbenoids from the stem of Gnetum latifolium (Gnetaceae)

Iliya, Ibrahim; Ali, Zulfıqar; Tanaka, Toŝhiyuki; Iinuma, Munekazu; Furusawa, Miyuki; Nakaya, Ken Ichi; Murata, Jin; Darnaedi, Dedy

doi:10.1016/s0031-9422(02)00289-3

Cited by 22 publications

(20 citation statements)

References 7 publications

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“…As part of the isolation and purification, eight stilbenoids were obtained from the roots and lianas of G. macrostachyum . These were categorized into three monomers, trans ‐resveratrol ( 1 ; Lin et al , ), isorhapotigenin ( 2 ; Lin et al , ) and gnetol ( 3 ; Lin et al , ), four dimers, bisisorhapontigenin B ( 4 ; Iliya et al , ), gnetin C ( 5 ; Boralle et al , ), parvifolol A ( 6 ; Tanaka et al , ) and gnetuhainin C ( 8 ; Saisin et al , ) and one trimer, latifolol ( 7 ; Iliya et al , ). The structures (Fig.…”

Section: Methodsmentioning

confidence: 99%

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Stilbenoids from Gnetum macrostachyum Attenuate Human Platelet Aggregation and Adhesion

Kloypan

Jeenapongsa

Sri-in

et al. 2012

Phytotherapy Research

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Platelets play a critical role in pathogenesis of cardiovascular disorders and strokes. The inhibition of platelet function is beneficial for the treatment and prevention of these diseases. The phytochemical investigation of stilbenoids from Gnetum macrostachyum Hook. f. led to the isolation of trans-resveratrol (1), isorhapotigenin (2), gnetol (3), bisisorhapontigenin B (4), gnetin C (5), parvifolol A (6), latifolol (7) and gnetuhainin C (8). The isolated stilbenoids were evaluated for in vitro antiplatelet activities via agonist-induced platelet aggregation and static platelet-collagen adhesion assays using washed human platelets. Compounds 1, 2 and 3 were active in the inhibition of arachidonic acid (AA)-induced platelet aggregation. Compound 2 and its dimer, compound 4, were the most active stilbenoids in thrombin-induced platelet aggregation. Moreover, compounds 4, 5 and 6, tended to be more potent than monomeric and trimeric stilbenoids in a human platelet-collagen adhesion assay under static conditions. This is the first report of the antiplatelet activity of stilbenoids isolated from G. macrostachyum.

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Section: Methodsmentioning

confidence: 99%

“…, isorhapotigenin (2;Lin et al, 1991) and gnetol (3;Lin et al, 1991), four dimers, bisisorhapontigenin B (4;Iliya et al, 2002b), gnetin C (5;Boralle et al, 1993), parvifolol A (6;Tanaka et al, 2001) and gnetuhainin C (8;Saisin et al, 2009) and one trimer, latifolol (7;Iliya et al, 2002a). The structures(Fig.…”

mentioning

confidence: 99%

Stilbenoids from Gnetum macrostachyum Attenuate Human Platelet Aggregation and Adhesion

Kloypan

Jeenapongsa

Sri-in

et al. 2012

Phytotherapy Research

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“…A trimer was isolated from three Gnetum species, G. gnemon, 109 G. klossii 129 and G. latifolium, 130 and named latifolol 122. The structure was deduced as an oligomer of resveratrol and piceatanol .…”

Section: Miscellaneous Oligomersmentioning

confidence: 99%

Natural stilbenes: an overview

2009

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Natural stilbenes have been a hot research topic due to their intricate structures and diverse biological activities. Although their molecular backbone consists only of 1,2-diphenylethylene units, stilbenes show an enormous diversity with regard to the different units present, the degree of polymerisation, and the pattern of oligomer construction. From January 1995 to the end of 2008, more than 400 new naturally occurring stilbenes were isolated and identified, and this review focuses on their structural diversity, distribution, and bioactivity.

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“…2,3 In a continuation of our phytochemical studies on Gnetum species, [4][5][6][7][8][9] we report herein the isolation and structure elucidation of four new phenolic derivatives, gnetofurans A-C (1)(2)(3) and dihydropinosylvindiol (4), along with nine known compounds from a methanol-soluble part of the stems of G. klossii Merr. The known constituents were gnetifolin F (5), 10 isorhapontigenin, gnetol, (-)--viniferin, 11 gnetulin, 4 gnetins C and E, 12 latifolol, 7 and trans-resveratrol. 13 Gnetofuran A (1) H-7′/C-2′(6′) in the HMBC spectrum revealed the linkages between C-7/C-1, C-8/C-9, C-8′/C-5, and C-7′/C-1′, respectively.…”

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confidence: 99%

Phenolic Constituents of Gnetum klossii

et al. 2003

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Four new phenolic derivatives, gnetofurans A-C (1-3) and dihydropinosylvindiol (4), were isolated from a methanol-soluble extract of the stems of Gnetum klossii, together with nine known compounds [gnetifolin F (5), isorhapontigenin, gnetulin, gnetins E and C, latifolol, gnetol, (-)-epsilon-viniferin, and trans-resveratrol]. The structures of the new compounds were determined by spectral data analysis.

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Stilbenoids from the stem of Gnetum latifolium (Gnetaceae)

Cited by 22 publications

References 7 publications

Stilbenoids from Gnetum macrostachyum Attenuate Human Platelet Aggregation and Adhesion

Stilbenoids from Gnetum macrostachyum Attenuate Human Platelet Aggregation and Adhesion

Natural stilbenes: an overview

Phenolic Constituents of Gnetum klossii

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