20 Years of Computational Neuroscience 2013
DOI: 10.1007/978-1-4614-1424-7_9
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Still Looking for the Memories: Molecules and Synaptic Plasticity

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Cited by 3 publications
(5 citation statements)
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“…Usually, the distinct periods, early phase and late phase, are defined to distinguish the time frames with or without alterations on gene expressions during synaptic plasticity [25,42,43]. Evidence suggests that the early phase LTP (E-LTP) is initiated by a single train of high-frequency stimulation and lasts for less than 3 hours, while late phase LTP (L-LTP) requires multiple trains of high-frequency stimulations separated by more than 5 minutes and lasts for at least 10 hours [42,49]. Several studies strongly suggest that the late phase of synaptic plasticity is accompanied by morphogenesis changes of dendritic spine and has a strong relationship to memory consolidation [22,32].…”
Section: Importance Of Synaptic Plasticitymentioning
confidence: 99%
“…Usually, the distinct periods, early phase and late phase, are defined to distinguish the time frames with or without alterations on gene expressions during synaptic plasticity [25,42,43]. Evidence suggests that the early phase LTP (E-LTP) is initiated by a single train of high-frequency stimulation and lasts for less than 3 hours, while late phase LTP (L-LTP) requires multiple trains of high-frequency stimulations separated by more than 5 minutes and lasts for at least 10 hours [42,49]. Several studies strongly suggest that the late phase of synaptic plasticity is accompanied by morphogenesis changes of dendritic spine and has a strong relationship to memory consolidation [22,32].…”
Section: Importance Of Synaptic Plasticitymentioning
confidence: 99%
“…Computational neuroscience is a broad and diverse field, with a large number of studies that model synaptic plasticity from a variety of different perspectives, levels of detail, and specific synaptic systems (such as cortical, hippocampal, striatal, and cerebellar); indeed, a 2010 paper reviewed and classified some 117 models published between 1985 and 2009, the authors of which repeatedly apologize for excluding many other models [63]. Despite the fact that several prominent researchers in the field have drawn attention to the importance of scaffold proteins at the synapse [9,13,53,71], no known computational modelling work has addressed the effects of scaffolding on synaptic signal transduction. Part of the reason for this is surely due to the sheer number of scaffolds in the postsynaptic density [42] and our current lack of detailed kinetic data for most of their interactions [89].…”
Section: Chapter 3 Related Workmentioning
confidence: 99%
“…Synaptic plasticity is the activity-dependent modification of the strength of connections between neurons, and has been proposed as a cellular mechanism underlying learning and memory [9]. In the last few decades, the volume of research on synaptic plasticity has dramatically increased, producing many significant advances.…”
Section: Introduction 11 Overviewmentioning
confidence: 99%
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