“…Computational neuroscience is a broad and diverse field, with a large number of studies that model synaptic plasticity from a variety of different perspectives, levels of detail, and specific synaptic systems (such as cortical, hippocampal, striatal, and cerebellar); indeed, a 2010 paper reviewed and classified some 117 models published between 1985 and 2009, the authors of which repeatedly apologize for excluding many other models [63]. Despite the fact that several prominent researchers in the field have drawn attention to the importance of scaffold proteins at the synapse [9,13,53,71], no known computational modelling work has addressed the effects of scaffolding on synaptic signal transduction. Part of the reason for this is surely due to the sheer number of scaffolds in the postsynaptic density [42] and our current lack of detailed kinetic data for most of their interactions [89].…”